Anterior cingulate cortex disconnectivity in high-risk offspring of bipolar patients: a preliminary DTI study

Beşenek, Mert

doi:10.14744/dajpns.2019.00030

Cited by 4 publications

(4 citation statements)

References 43 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the mechanisms of psychiatric disorders are assumed to have a strong neurodevelopmental component ( Insel, 2010 ) and deviant developmental trajectories have been observed in imaging data of youths with early signs of psychiatric disorders ( Besenek, 2020 , Chung et al, 2018 , Collin et al, 2020 , Kaufmann et al, 2017 , Lian et al, 2018 , Saito et al, 2020 ), estimating brain age gap as a proxy for maturation in young individuals may provide further insights into the early phases of the disorders. Indeed, an increase in anatomical brain age gaps has been observed in association with psychopathology in children and adolescents ( Chung et al, 2018 , Cropley et al, 2020 , Franke et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms

Lund

Alnæs

Lange

et al. 2022

NeuroImage: Clinical

View full text Add to dashboard Cite

Highlights We used resting-state fMRI data from the Philadelphia Neurodevelopmental Cohort to derive a brain age prediction model based on functional brain connectivity. The model was able to predict brain age in independent data (the Healthy Brain Network sample). Our findings support consistency in functional connectivity patterns between samples and scanners and support the utility of the brain age prediction framework for fMRI based multisite investigations.

show abstract

Section: Introductionmentioning

confidence: 99%

Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms

Lund

Alnæs

Lange

et al. 2022

NeuroImage: Clinical

View full text Add to dashboard Cite

show abstract

“…Lower FA in the specific portions of bilateral ATR that we observed might contribute more to emotional dysregulation and aberrant reward processing because of their proximity to subcortical limbic structures involved in emotional regulation and reward processing. Other studies, however, did not report any differences in FA in the ATR in BD versus healthy OBP [ 82 ], in BD versus their healthy first-degree relatives [ 39 ], and in BD versus youth with a first-degree BD relative [ 32 , 38 ]. Additionally, previous studies [ 32 , 33 , 35 – 37 , 83 , 84 ] and a recent meta-analysis [ 30 ] reported significantly lower FA in BD than healthy controls in several tracts.…”

Section: Discussionmentioning

confidence: 99%

Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth

Rozovsky

Versace

Bonar

et al. 2021

Neuropsychopharmacol.

View full text Add to dashboard Cite

Bipolar disorder (BD) is highly heritable. Identifying objective biomarkers reflecting pathophysiological processes predisposing to, versus protecting against BD, can help identify BD risk in offspring of BD parents. We recruited 21 BD participants with a first-degree relative with BD, 25 offspring of BD parents, 27 offspring of comparison parents with non-BD psychiatric disorders, and 32 healthy offspring of healthy parents. In at-risk groups, 23 had non-BD diagnoses and 29, no Axis-I diagnoses(healthy). Five at-risk offspring who developed BD post scan(Converters) were included. Diffusion imaging(dMRI) analysis with tract segmentation identified between-group differences in the microstructure of prefrontal tracts supporting emotional regulation relevant to BD: forceps minor, anterior thalamic radiation(ATR), cingulum bundle(CB), and uncinate fasciculus(UF). BD participants showed lower fractional anisotropy (FA) in the right CB (anterior portion) than other groups (q < 0.05); and in bilateral ATR (posterior portion) versus at-risk groups (q < 0.001). Healthy, but not non-BD, at-risk participants showed significantly higher FA in bilateral ATR clusters than healthy controls (qs < 0.05). At-risk groups showed higher FA in these clusters than BD participants (qs < 0.05). Non-BD versus healthy at-risk participants, and Converters versus offspring of BD parents, showed lower FA in the right ATR cluster (qs < 0.05). Low anterior right CB FA in BD participants versus other groups might result from having BD. High bilateral ATR FA in at-risk groups, and in healthy at-risk participants, versus healthy controls might protect against BD/other psychiatric disorders. Absence of elevated right ATR FA in non-BD versus healthy at-risk participants, and in Converters versus non-converter offspring of BD parents, might lower protection against BD in at-risk groups.

show abstract

“…Missing information was requested from the corresponding authors of 33 studies. We obtained missing data from 13 studies 26,27,[33][34][35][36][37][38][39][40][41][42][43] . Using the Newcastle-Ottawa assessment scale (NOS), we evaluated the quality of all studies based on how the study groups were selected, how comparable they were, and how their DTI metrics were ascertained 44 (Supplementary Table S3).…”

Section: Literature Searches Data Extractionmentioning

confidence: 99%

The role of the uncinate fasciculus in the risk-architecture of bipolar disorders: A meta-analysis

Nguyen

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundBipolar disorder (BD) is a severe mental disorder, characterized by prominent mood swings and emotion regulation (ER) deficits. The uncinate fasciculus (UF), a white matter tract connecting the amygdala and the ventral prefrontal cortex, has been implicated in ER. Aberrancies in UF microstructure may be an endophenotype associated with increased risk for BD. However, findings in individuals with BD and at familial risk for BD (AR) have yielded inconsistent findings. This meta-analysis takes a region-of-interest approach to consolidate the available evidence and elucidate the role of the UF in the risk-architecture of BD.MethodsUsing web-based search engines, we identified diffusion tensor imaging studies focusing on the left and right UF and conducted meta-analyses comparing fractional anisotropy (FA) and radial diffusivity (RD) between BD or AR to healthy volunteers (HV).ResultsWe included 32 studies (nBD=1186, nHV=2001; nAR=289, nHV=314). Compared to HV, individuals with BD showed lower FA in the right (p<.0001) and left UF (p=.010), and higher RD in the right UF (p=.009). We found no significant differences between AR and HV. In the right but not the left UF, AR individuals showed higher FA than BD (p=.043).ConclusionComparable UF microstructure between AR and HV and higher FA in the right UF in AR compared to BD suggest that aberrancies in UF microstructure is not an endophenotype for BD. Longitudinal studies are needed to determine when UF abnormalities emerge in the context of BD.

show abstract

Anterior cingulate cortex disconnectivity in high-risk offspring of bipolar patients: a preliminary DTI study

Cited by 4 publications

References 43 publications

Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms

Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms

Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth

The role of the uncinate fasciculus in the risk-architecture of bipolar disorders: A meta-analysis

Contact Info

Product

Resources

About