Anterior hypothalamic lesions and pubertal development in female rhesus monkeys

Jj, van der Werff ten Bosch; Dj, Dierschke; Terasawa, Ei; Ak, Slob

doi:10.1016/0166-4328(83)90023-2

Cited by 9 publications

(4 citation statements)

References 17 publications

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“…Despite the fact that three of the six animals with anterior hypothalamic lesions reached menarche and first ovulation earlier than controls, we are reluctant to conclude that anterior hypothalamic lesions induced precocious puberty, as did posterior hypothalamic lesions, for the following reasons: the age of menarche in the remaining three animals surviving 22-60 months postoperatively was in the normal range or tended to be delayed, and developmental changes in LH as well as nipple growth and the growth curve of body weight were similar to those in controls and dissimilar to those in animals with posterior hypothalamic lesions. In a previous study (16), lesions of the anterior hypothalamus also did not cause significant effects. A recent clinical study (23) of patients with pathological lesions in the hypothalamus suggests that these lesions seem to result in delayed puberty.…”

Section: Discussionmentioning

confidence: 74%

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Posterior Hypothalamic Lesions Advance the Onset of Puberty in the Female Rhesus Monkey*

et al. 1984

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The effects of experimental lesions in the posterior hypothalamus and the anterior hypothalamus on menarche and first ovulation were examined in nonhuman primates. With the aid of x-ray ventriculography, bilateral lesions were made by passing a radiofrequency current through a thermister electrode in the posterior hypothalamus (n = 7) or the anterior hypothalamus (n = 6) of female rhesus monkeys at 18 months of age. Four animals that received sham lesions as well as four normal females of a similar age served as controls. All animals were caged individually and examined daily for vaginal bleeding and sex skin color change. Developmental changes in gonadotropins, ovarian steroids, body weight, and nipple size were monitored throughout the experiments. The time of first ovulation was determined by laparoscopic observation of the newly formed corpus luteum and by the level of circulating progesterone. Histological examination confirmed that the bilateral lesions in the hypothalamus were approximately 2-3 mm in diameter and overlapped midline. Primary sites of posterior hypothalamic lesions included the premamillary area and the posterior nucleus, while the infundibular nucleus and the median eminence were entirely spared. The posterior lesions encroached upon the mamillary nuclei caudally in most cases and upon the ventromedial nucleus rostrally in some cases. Primary sites of anterior hypothalamic lesions included the medial preoptic area, the periventricular preoptic nucleus, and the anterior hypothalamic nucleus. Partial lesions of the diagonal bundle of Broca, the medial preoptic nucleus, and the paraventricular nucleus were also detected. Posterior hypothalamic lesions advanced the ages at menarche (22.2 +/- 1.3 months; P less than 0.001) and first ovulation (40.7 +/- 2.7 months; P less than 0.05) compared to those of control animals (menarche, 30.3 +/- 3.1; first ovulation, 51.2 +/- 3.3 months). The body weight at menarche of these lesioned animals (2.62 +/- 0.11 kg) was smaller (P less than 0.05) than that of controls (3.14 +/- 0.20 kg), but the body weight at first ovulation of lesioned animals (4.36 +/- 0.28 kg) was not different from that of controls (4.57 +/- 0.13 kg). Hormonal and physical changes during maturation, i.e. an increase in circulating estradiol and growth in nipple size before menarche and first ovulation, occurred earlier in the lesioned animals and the growth spurt before first ovulation not only began earlier but also attained mature levels several months earlier than that in control animals.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: Discussionmentioning

confidence: 74%

“…Complete deafferentation of the medial basal hypothalamus advanced the age of first ovulation, but not menarche, in one study (14), while in another study, the same procedure advanced neither menarche nor first ovulation (15). Lesions of the anterior hypothalamus also did not cause any significant effects on sexual maturation (16).…”

Section: Detectedmentioning

confidence: 93%

Posterior Hypothalamic Lesions Advance the Onset of Puberty in the Female Rhesus Monkey*

et al. 1984

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“…An increase in kisspeptin cells with age is observed in the POA of ewes using ISH, but these cell numbers do not correlate with the pubertal increase in LH pulse frequency (27), and few, if any cells, are detected by ICC in pre-and postpubertal ewe lambs (28). There is no information on pubertal changes in rostral kisspeptin cell number in rhesus monkeys, but in light of earlier data that rostral lesions or knife cuts either had no effect on (87,88) or advanced (89) the onset of puberty, it is unlikely that they are critical in this species.…”

Section: Pubertymentioning

confidence: 87%

Kisspeptin Neurons from Mice to Men: Similarities and Differences

Goodman

Lehman

2012

Endocrinology

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The discovery that kisspeptin was critical for normal fertility in humans ushered in a new chapter in our understanding of the control of GnRH secretion. In this paper, we will review recent data on the similarities and differences across several mammalian species in the role of kisspeptin in reproductive neuroendocrinology. In all mammals examined to date, there is strong evidence that kisspeptin plays a key role in the onset of puberty and is necessary for both tonic and surge secretion of GnRH in adults, although kisspeptin-independent systems are also apparent in these studies. Similarly, two groups of kisspeptin neurons, one in the arcuate nucleus (ARC) and the other more rostrally, have been identified in all mammals, although the latter is concentrated in a limited area in rodents and more scattered in other species. Estrogen has divergent actions on kisspeptin expression in these two regions across these species, stimulating it the latter and inhibiting expression in the former. There is also strong evidence that the rostral population participates in the GnRH surge, whereas the ARC population contributes to steroid-negative feedback. There may be species differences in the role of these two populations in puberty, with the ARC cells important in rats, sheep, and monkeys, whereas both have been implicated in mice. ARC kisspeptin neurons also appear to participate in the GnRH surge in sheep and guinea pigs, whereas the data on this possibility in rodents are contradictory. Similarly, both populations are sexually dimorphic in sheep and humans, whereas most data in rodents indicate that this occurs only in the rostral population. The functional consequences of these species differences remain to be fully elucidated but are likely to have significance for understanding normal neuroendocrine control of reproduction as well as for use of kisspeptin agonists/antagonists as a therapeutic tool.

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“…Observational studies on the sexual behavior development of female Old World monkeys and apes are greatly strengthened by the fact that the physiological and anatomical changes accompanying puberty have been fairly well described. Menarche is widely regarded as an overt sign of their commencement (Hartman, 1932;Young & Yerkes, 1943;Gilbert & Gillman, 1960;Van Wagenen, 1972;Erwin & Erwin, 1976;Foster, 1977;Resko, Goy, Robinson & Norman, 1982;van der Werff ten Bosch, 1982; van der Werff ten Bosch, Dierschke, Terasawa & Slob, 1983).…”

mentioning

confidence: 99%

Male chacma baboon (Papio ursinus) sexual arousal: Studies with adolescent and adult females as visual stimuli

Bielert

Girolami

Anderson

1986

Developmental Psychobiology

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Studies were carried out to determine the effectiveness of adolescent female chacma baboons (Pupio ursinus) as sexual arousal stimuli for adult male conspecifics. Coagulated seminal emissions were scored as the dependent variable. Five adolescent females were compared to adult females in terms of menstrual cycle, sexual arousal stimulation success, and behavior.The adolescents differed from their adult controls in menstrual cycle length, duration of menses, days to full turgescence, and days from sex skin detumescence until next menses. Although their maximal swellings were recognizably smaller than those of the adults the adolescents did not differ from the adults in the number of days during which their perineums were fully turgid. The younger females were not as effective an arousal stimulus as were the adults. However, behavioral observations on four of the adolescent/ adult female pairs clearly demonstrated that young females exhibit the same proceptive behaviors and at similar levels as adults. "Lip smacking" and "presenting," were shown by both age classes of females. In the case of presenting, adolescents showed highh frequencies of this behavior particularly during the phase of the cycle which could be called "early follicular."On the basis of the obtained results it is suggested that the differential male responsiveness may not be due to behavioral differences between the 2 classes of females but rather to absolute perineal swelling size. Since adolescent swellings, although physically ~ ~~

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Anterior hypothalamic lesions and pubertal development in female rhesus monkeys

Cited by 9 publications

References 17 publications

Posterior Hypothalamic Lesions Advance the Onset of Puberty in the Female Rhesus Monkey*

Posterior Hypothalamic Lesions Advance the Onset of Puberty in the Female Rhesus Monkey*

Kisspeptin Neurons from Mice to Men: Similarities and Differences

Male chacma baboon (Papio ursinus) sexual arousal: Studies with adolescent and adult females as visual stimuli

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