Anterior Mandibular Displacement in Growing Rats—A Systematic Review

Abstract

Skeletal Class II malocclusion is the most common skeletal anomaly in orthodontics. Growth in the body of the deficient mandible is induced by periosteal apposition and endochondral ossification in the condyle. Functional appliances have been used in the correction of Class II malocclusions by inducing mandibular growth. Despite their utilization though, their effect still remains controversial. The aim of the present study is to review the existing literature regarding the effects of mandibular protrusion in mandibular growth of growing rats. A protocol was followed according to the guidelines of the Cohrane Handbook for Systematic Reviews. Databases were searched using a specific algorithm. From the ten studies finally analyzed, we conclude that the use of a functional appliance in growing rats induces cell proliferation and bone formation in their condyles, resulting in mandibular growth.

Histological and Biochemical Analysis after Posterior Mandibular Displacement in Rats

“…Mandibular displacement is related to bone remodeling [24,30,31]. One of the aims of this study was to uncover any alteration in circulating biomolecules that are connected to osseous turnover which might reveal the dissemination of unwanted effects throughout the organism with ensuing dysregulation.…”