1981
DOI: 10.1210/jcem-53-1-165
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Anterior Pituitary Function after Transsphenoidal Selective Adenomectomy in Patients with Cushing's Disease*

Abstract: The anterior pituitary function in 25 patients with Cushing's disease was assessed before and after transsphenoidal adenomectomy. Pituitary adenoma was detected and removed in 24 cases, resulting in clinical remission in 22. Postoperative hypoadrenocorticism was observed in all of the cases with remission, necessitating substitution of glucocorticoid. One case had a recurrence after a year in remission. Plasma ACTH and cortisol rapidly decreased after surgery and remained at subnormal levels. However, diurnal … Show more

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Cited by 71 publications
(30 citation statements)
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“…Improvement or normalization of GH responses to hypoglycemia have been shown in 30% to 100% of cases of patients with CD in remission in several large series (21)(22)(23). This variability could be due to different GH cut off values for GH deficiency and also to the type of treatment used.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Improvement or normalization of GH responses to hypoglycemia have been shown in 30% to 100% of cases of patients with CD in remission in several large series (21)(22)(23). This variability could be due to different GH cut off values for GH deficiency and also to the type of treatment used.…”
Section: Discussionmentioning
confidence: 99%
“…This suggests that the secretory ability of the somatotroph can be restored in these patients. However, there are controversial results about the GH secretory state in CD after remission of hypercortisolism induced by transphenoidal surgery or radiotherapy (21)(22)(23)(24)(25)(26)(27).…”
mentioning
confidence: 99%
“…Three of our patients had preoperative hypothyroidism, which commonly occurs with Cushing's syndrome [5] and which usually disappears after resolution of hypercortisolism. [8,15] Hypothyroidism resolved in two of these patients; the other patient had panhypopituitarism after surgery, which also occurred in the patient with preoperative hypogonadism and a tumor high in the pituitary stalk next to the optic chiasm. Three female patients with preoperative amenorrhea resumed normal menses after surgery.…”
Section: Discussionmentioning
confidence: 92%
“…Postoperative hypoadrenocorticism could consistently be observed in most patients with clinical remission [28][29][30][31].…”
Section: Discussionmentioning
confidence: 99%