Anterior segment optical coherence tomography scanning protocols and corneal thickness repeatability

Fisher, Damien; Collins, Michael J.; Vincent, Stephen J.

doi:10.1016/j.clae.2019.12.008

Cited by 10 publications

(15 citation statements)

References 52 publications

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“…2, top panel). 35 Given the differences between the methodology of this study (90 min of unilateral eyelid closure) and the parameters of the theoretical model (bilateral overnight eyelid closure), it is not possible to directly compare the absolute magnitude of edema between studies because a longer duration of lens wear would result in more edema, consistent with previous empirical data. 25 However, the effect of scleral lens Dk/t on edema during lid closure for the theoretical model can be more readily compared with the experimental data if the change in corneal edema is examined relative to the magnitude of edema observed for a high Dk/t value (e.g., Dk/t 70) (Fig.…”

Section: Discussionsupporting

confidence: 51%

“…Top panel: Corrected central corneal edema after short-term closed eye scleral lens wear (empirical data from this study, red line) and predicted central corneal edema after overnight scleral lens wear extracted from the model proposed by Kim et al 35 (green line) as a function of lens Dk/t. Horizontal and vertical error bars are the standard error of the mean.…”

Section: Resultsmentioning

confidence: 99%

“…32,33 This is a highly reliable technique with a mean±SD intraobserver repeatability of 0.3±1.6 μm and intrasession repeatability of −0.7±1.9 μm for measures of total corneal thickness (when averaging 3 OCT line scans across the central 6 mm using a single observer). 35…”

Section: Methodsmentioning

confidence: 99%

“…Corrected central corneal edema as a function of scleral lens Dk/t from empirical data measured in this study and theoretical modeling of overnight scleral lens wear 35 are shown in Figure 2. As expected, the magnitude of edema induced after 90 min of closed eye lens wear was substantially less than that predicted for overnight lens wear (Fig.…”

Section: Comparison With Theoretical Modelingmentioning

confidence: 95%

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Scleral Lens Thickness and Corneal Edema Under Closed Eye Conditions

Fisher

Collins

Vincent

2021

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Objectives:To examine the relationship between central lens thickness and central corneal edema during short-term closed eye scleral lens wear.Methods:Nine participants (mean age 30 years) with normal corneas wore scleral lenses (Dk 141) under closed eye conditions on separate days with nominal center thicknesses of 150, 300, 600, and 1,200 μm. Epithelial, stromal, and total corneal edema were measured using high-resolution optical coherence tomography immediately after lens application and after 90 min of wear, before lens removal. Data were corrected for variations in initial fluid reservoir thickness and compared with predictions from theoretical modeling of overnight scleral lens wear.Results:Scleral lens–induced central corneal edema was primarily stromal in nature. The mean±standard error of corrected total corneal edema was 4.31%±0.32%, 4.55%±0.42%, 4.92%±0.50%, and 4.83%±0.22% for the 150-, 300-, 600-, and 1,200-μm lenses, respectively. No significant differences in the corrected total corneal edema were observed across all thickness groups (P=0.20). Theoretical modeling of overnight scleral lens wear seemed to overestimate the relative increase in central corneal edema as a function of decreasing lens Dk/t for values lower than 25.Conclusion:The magnitude of scleral lens–induced central corneal edema during short-term closed eye lens wear did not vary significantly with increasing central lens thickness. Theoretical modeling of overnight closed eye scleral lens wear seems to overestimate the effect of increasing lens thickness.

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Section: Discussionsupporting

confidence: 51%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Comparison With Theoretical Modelingmentioning

confidence: 95%

See 2 more Smart Citations

Scleral Lens Thickness and Corneal Edema Under Closed Eye Conditions

Fisher

Collins

Vincent

2021

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…It enables quantitative measurement of corneal epithelial, stromal, and endothelial thicknesses. 11 , 12 Given the fact that BASK was commonly observed in patients receiving belantamab mafodotin, it is important to evaluate this novel finding objectively. Herein, we present AS-OCT findings of two RRMM patients who developed BASK during their treatment course.…”

Section: Introductionmentioning

confidence: 99%

Structural changes of corneal epithelium in belantamab-associated superficial keratopathy using anterior segment optical coherence tomography

Matsumiya

Karaca

Ghoraba

et al. 2021

American Journal of Ophthalmology Case Reports

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Purpose To describe structural changes in corneal epithelium using anterior segment optical coherence tomography (AS-OCT) in two relapsed and refractory multiple myeloma (RRMM) patients with bilateral belantamab-associated superficial keratopathy (BASK). Observations: case 1 A 56-year-old male who was diagnosed with RRMM and initiated on belantamab mafodotin, presented on day 42 (three weeks after the second infusion) with decreased pinhole visual acuity from 20/20 and 20/25 to 20/70 and 20/50 in the right eye and left eye, respectively. Slit-lamp examination revealed moderate superficial keratopathy with microcystic-like epithelial changes (MECs) in the paracentral cornea in both eyes. AS-OCT demonstrated increased bilateral heterogeneous signal intensity and hyperreflective lesions as well as increased thickness in the paracentral corneal epithelium with uninvolved central cornea. Given bilateral MECs, the third infusion was withheld, and then given on day 62 after five weeks of drug-free interval. Although MECs had improved on day 82, pinhole visual acuity remained at 20/50 and 20/40 in the right eye and the left eye. AS-OCT showed that hyperreflective lesions mostly resolved and corneal epithelial thickness returned to baseline, despite a slightly increased persisting heterogeneous signal intensity in the peripheral corneal epithelium in both eyes. Case 2 A 77-year-old male with RRMM was started on belantamab mafodotin infusions. His pinhole visual acuity decreased from 20/40 and 20/30 at baseline to 20/60 and 20/40 on day 41 (three weeks after the second infusion) in the right eye and left eye, respectively. Slit-lamp examination showed diffuse, moderate MECs in both eyes, which was more severe in the peripheral cornea. AS-OCT demonstrated increased bilateral heterogeneous signal intensity and hyperreflective lesions in the corneal epithelium, which are more severe in the right eye along with increased corneal epithelial thickness. Therefore, belantamab mafodotin was withheld. Conclusions and Impotance AS-OCT objectively demonstrated structural changes such as signal intensity and thickness alterations with hyperreflective lesions in the corneal epithelium related to BASK. AS-OCT might be useful for clinicians to monitor ocular surface adverse events in RRMM patients receiving belantamab mafodotin and to adjust therapeutic plans for the patients.

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