Anterior segment optical coherence tomography in ocular surface tumours and simulating lesions

Optical Biopsy Using Anterior-Segment Optical Coherence Tomography in Ocular Surface Tumors: The Game Changer

“…Although AS-OCT offers similar if not better results in demonstrating internal tumor features, [7][8][9] ultrasound biomicroscopy can better define tumor boundaries and tumor thickness in larger or pigmented ocular surface lesions and in lesions located posterior to the iris pigment epithelium. [7][8][9] As of today, further limitations for the use of AS-OCT in ocular surface tumors include inability to visualize large conjunctival tissues in a single screen; inability to observe details of underlying tissues in leukoplakic, thick, and pigmented lesions; inability to make a clear distinction between invasive and intraepithelial variants of OSSN; and differential diagnosis between certain lesions such as OSSN and squamous papilloma, pinguecula, and epithelial dysplasia/keratotic plaque/ parakeratosis is not possible yet. Furthermore, diagnostic AS-OCT features have not been established for relatively rare tumors including vascular and neural tumors, oncocytoma, myxoma, and histiocytoma.…”