Anterior thalamic glutamatergic neurons modulate prefrontal cortical firing and regularity

Adeyelu, Tolulope; Ogundele, Olalekan Michael

doi:10.1016/j.neulet.2022.136565

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…To some extent motivation will be supplied by limbic cortex via its circuits with the prefrontal cortex. However, output from these areas, via the Papez circuit, to the hippocampal formation then receives hippocampal and hypothalamic processing before returning in a modified form to the prefrontal cortex via the thalamus [ 95 ]. Functional hippocampal output requires that it receives theta pattern input from the medial septum, dependent on arousal-related reticular and cerebellar input via areas such as SuM [ 61 ].…”

Section: What Triggers Iterative Processing?mentioning

confidence: 99%

Construction of complex memories via parallel distributed cortical–subcortical iterative integration

McNaughton

Vann

2022

Trends in Neurosciences

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Section: What Triggers Iterative Processing?mentioning

confidence: 99%

Construction of complex memories via parallel distributed cortical–subcortical iterative integration

McNaughton

Vann

2022

Trends in Neurosciences

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“…Putative glutamatergic neurons were identified by their wide spike waveform (fullwidth at half-maximum $ 0.30 ms) and sharp autocorrelogram. 1,5 The spontaneous firing was first recorded for 2 minutes before recording the firing evoked by sequential innocuous brush and noxious pinch. Brush stimulation was applied by brushing the hind paw lightly for 60 seconds with a hairbrush, whereas pinch stimulation was applied by clipping the hind paw for 30 seconds using a toothed plastic clip.…”

Section: In Vivo Single-unit Recordingsmentioning

confidence: 99%

Secondary somatosensory cortex glutamatergic innervation of the thalamus facilitates pain

Guo,

Lin,

et al. 2023

Pain

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Although the secondary somatosensory cortex (SII) is known to be involved in pain perception, its role in pain modulation and neuropathic pain is yet unknown. In this study, we found that glutamatergic neurons in deep layers of the SII (SIIGlu) responded to bilateral sensory inputs by changing their firing with most being inhibited by contralateral noxious stimulation. Optical inhibition and activation of unilateral SIIGlu reduced and enhanced bilateral nociceptive sensitivity, respectively, without affecting mood status. Tracing experiments revealed that SIIGlu sent dense monosynaptic projections to the posterolateral nucleus (VPL) and the posterior nucleus (Po) of the thalamus. Optical inhibition and activation of projection terminals of SIIGlu in the unilateral VPL and Po inhibited and facilitated pain on the contralateral side, respectively. After partial sciatic nerve ligation, SIIGlu became hyperactive as evidenced by higher frequency of spontaneous firing, but the response patterns to peripheral stimulation remained. Optical inhibition of SIIGlu alleviated not only bilateral mechanical allodynia and thermal hyperalgesia but also the negative affect associated with spontaneous pain. Inhibition of SIIGlu terminals in the VPL and Po also relieved neuropathic pain. This study revealed that SIIGlu and the circuits to the VPL and Po constitute a part of the endogenous pain modulatory network. These corticothalamic circuits became hyperactive after peripheral nerve injury, hence contributes to neuropathic pain. These results justify proper inhibition of SIIGlu and associated neural circuits as a potential clinical strategy for neuropathic pain treatment.

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Anterior thalamic glutamatergic neurons modulate prefrontal cortical firing and regularity

Cited by 2 publications

References 20 publications

Construction of complex memories via parallel distributed cortical–subcortical iterative integration

Construction of complex memories via parallel distributed cortical–subcortical iterative integration

Secondary somatosensory cortex glutamatergic innervation of the thalamus facilitates pain

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