Anterior thalamic lesions and neuronal activity in the cingulate and retrosplenial cortices during discriminative avoidance behavior in rabbits.

Gabriel, Michael; Lambert, Richard W.; Foster, Kent; Orona, Edward; Sparenborg, Steven; Maiorca, Renee R.

doi:10.1037/0735-7044.97.5.675

Cited by 83 publications

(56 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When trained, the transected rabbits exhibited an average success rate of avoidances on 61% of CS+ trials, significantly less than the success rates (84% and 83%) exhibited respectively by rabbits with control and no lesions. A similar performance loss occurred previously in trained rabbits given avoidance training after bilateral anterior thalamic lesions (Gabriel et al, 1983). Thus, either direct destruction or deafferentation eliminated the specific contribution to avoidance behavior made by anterior thalamic neurons: maintenance but not original acquisition of the behavior.…”

Section: Discussionsupporting

confidence: 78%

“…The statistically significant effects obtained in analyses of the integrated unit activity are given for instances in which the effects were not significant but present as nonsignificant trends in the analysis of the spike frequency data. Several computer-and experimenter-controlled methods were used for exclusion of data samples containing movement artifacts (see Gabriel et al, 1983).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Mamillothalamic tract transection blocks anterior thalamic training- induced neuronal plasticity and impairs discriminative offidance behavior in rabbits

et al. 1995

View full text Add to dashboard Cite

Rabbits with bilateral transecting lesions of the mamillothalamic tract, control (tract-sparing and sham) lesions, or no lesions, and chronic, fixed-position anterior ventral (AV) and medial dorsal (MD) thalamic and posterodorsal subicular complex unit recording electrodes were trained to step in an activity wheel in response to a 0.5 sec tone (CS+) in order to avoid a brief foot shock. The rabbits also learned to ignore a different tone (CS-) not predictive of shock. Behavioral acquisition was significantly retarded in rabbits with mamillothalamic tract transection compared to controls. When trained, transected rabbits failed to avoid the shock more often than controls. Mamillothalamic tract transection abolished and control lesions attenuated AV thalamic discriminative training-induced activity (i.e., development with training of greater discharges in response to the CS+ than to the CS-). Transection and control lesions attenuated AV thalamic excitatory training-induced activity (greater elicited activity during training than during unpaired tone-shock presentations before training) as well as AV thalamic “spontaneous” baseline unit activity. CS-elicited discharge magnitude was reduced by control lesions and it was further reduced by tract transecting lesions. Significant lesion-related changes were not found in the subicular or MD thalamic neuronal receptor. Mamillothalamic tract afferent information flow is thus essential for AV thalamic discriminative training-induced activity, excitatory training-induced activity, tone- elicited discharges and maintenance of conditioned avoidance responses. The effects of the control lesions suggested that afferents which course in parallel with and near the mamillothalamic tract may contribute to AV thalamic spontaneous activity and excitatory training- induced activity.

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Mamillothalamic tract transection blocks anterior thalamic training- induced neuronal plasticity and impairs discriminative offidance behavior in rabbits

et al. 1995

View full text Add to dashboard Cite

show abstract

“…These findings, along with others (e.g., Gabriel et al 1983;Kwapis et al 2014Kwapis et al , 2015, indicate the RSC is involved in mnemonic processing related to auditory information. However, to date, no neuroanatomical studies have systematically investigated RSC connectivity with auditory regions.…”

Section: Behaviorsupporting

confidence: 78%

“…Although the RSC has a well-established role in spatial and contextual learning and memory, an emerging literature suggests it also has an important role in processing discrete cues (Gabriel et al 1983;Keene and Bucci 2008b;Robinson et al 2012Robinson et al , 2014. The present experiments extended this work by examining the contribution of the RSC to remote memory retrieval, using a signaled fear conditioning procedure with an auditory cue.…”

Section: Discussionmentioning

confidence: 57%

Retrosplenial cortex is required for the retrieval of remote memory for auditory cues

et al. 2016

View full text Add to dashboard Cite

The restrosplenial cortex (RSC) has a well-established role in contextual and spatial learning and memory, consistent with its known connectivity with visuo-spatial association areas. In contrast, RSC appears to have little involvement with delay fear conditioning to an auditory cue. However, all previous studies have examined the contribution of the RSC to recently acquired auditory fear memories. Since neocortical regions have been implicated in the permanent storage of remote memories, we examined the contribution of the RSC to remotely acquired auditory fear memories. In Experiment 1, retrieval of a remotely acquired auditory fear memory was impaired when permanent lesions (either electrolytic or neurotoxic) were made several weeks after initial conditioning. In Experiment 2, using a chemogenetic approach, we observed impairments in the retrieval of remote memory for an auditory cue when the RSC was temporarily inactivated during testing. In Experiment 3, after injection of a retrograde tracer into the RSC, we observed labeled cells in primary and secondary auditory cortices, as well as the claustrum, indicating that the RSC receives direct projections from auditory regions. Overall our results indicate the RSC has a critical role in the retrieval of remotely acquired auditory fear memories, and we suggest this is related to the quality of the memory, with less precise memories being RSC dependent.

show abstract

“…Several computer-, and experimenter-controlled methods were used to exclude neuronal data containing movement-related artifacts (see Gabriel et al, 1983;Kubota and Gabriel, 1995).…”

Section: Methodsmentioning

confidence: 99%

Medial Geniculate Lesions Block Amygdalar and Cingulothalamic Learning-Related Neuronal Activity

Poremba

Gabriel

1997

J. Neurosci.

Self Cite

View full text Add to dashboard Cite

This study assessed the role of the thalamic medial geniculate (MG) nucleus in discriminative avoidance learning, wherein rabbits acquire a locomotory response to a tone [conditioned stimulus (CS)ϩ] to avoid a foot shock, and they learn to ignore a different tone (CSϪ) not predictive of foot shock. Limbic (anterior and medial dorsal) thalamic, cingulate cortical, or amygdalar lesions severely impair acquisition, and neurons in these areas develop training-induced activity (TIA): more firing to the CSϩ than to the CSϪ. MG neurons exhibit TIA during learning and project to the amygdala. The MG neurons may supply afferents essential for amygdalar and cingulothalamic TIA and for avoidance learning. To test this hypothesis, bilateral electrolytic or excitotoxic ibotenic acid MG nuclear lesions were induced, and multiunit recording electrodes were chronically implanted into the anterior and posterior cingulate cortex, the anterior-ventral and medial-dorsal thalamic nuclei, and the basolateral nucleus of the amygdala before training. Learning was severely impaired and TIA was abolished in all areas in rabbits with lesions. Thus learning and TIA require the integrity of the MG nucleus. Only damage in the medial MG division was significantly correlated with the learning deficit. The lesions abolished the sensory response of amygdalar neurons, and they attenuated (but did not eliminate) the sensory response of cingulothalamic neurons, suggesting the existence of extra geniculate sources of auditory transmission to the cingulothalamic areas. Key words: limbic thalamus; cingulate cortex; amygdala; learning; instrumental conditioning; anterior ventral nucleus; medial dorsal nucleusThere is currently a great interest in the neural circuitry underlying aversively motivated learning (for review, see Davis, 1992;Gabriel, 1993;Lennartz and Weinberger, 1994;LeDoux, 1995;McGaugh et al., 1995;. A central role of amygdalar neurons is indicated by findings that amygdala lesions impair the acquisition of conditioned immobility (LeDoux et al., 1988; Fanselow and K im, 1994;LeDoux, 1995), autonomic responding (Blanchard and Blanchard, 1972;Spevack et al., 1975;Kapp et al., 1979;Gentile et al., 1986;Iwata et al., 1986;Helmstetter, 1992) and fear-potentiated startle behavior (Davis, 1986(Davis, , 1992Hitchcock and Davis, 1987;Sananes and Davis, 1992). Also, amygdalar neurons exhibit associative, training-induced activity (TIA) during Pavlovian conditioning (Umemoto and Olds, 1975;Applegate et al., 1982;Pascoe and Kapp, 1985;Nishijo et al., 1988; Muramoto et al., 1993;McEchron et al., 1995;Quirk et al., 1995).An involvement of the medial geniculate (MG) nucleus in aversively motivated learning is indicated by the observation of TIA in the medial division of the MG nucleus (MGm) (Olds et al., 1972;Gabriel et al., 1975;Gabriel et al., 1976;Ryugo and Weinberger, 1978;Birt and Olds, 1981;Weinberger, 1982;Edeline, 1990;Edeline and Weinberger, 1992;McEchron et al., 1995), and by impaired conditioning in animals with MG lesions (Iwata et al., 198...

show abstract

Anterior thalamic lesions and neuronal activity in the cingulate and retrosplenial cortices during discriminative avoidance behavior in rabbits.

Cited by 83 publications

References 11 publications

Mamillothalamic tract transection blocks anterior thalamic training- induced neuronal plasticity and impairs discriminative offidance behavior in rabbits

Mamillothalamic tract transection blocks anterior thalamic training- induced neuronal plasticity and impairs discriminative offidance behavior in rabbits

Retrosplenial cortex is required for the retrieval of remote memory for auditory cues

Medial Geniculate Lesions Block Amygdalar and Cingulothalamic Learning-Related Neuronal Activity

Contact Info

Product

Resources

About