Anterior thalamus deep brain stimulation at high current impairs memory in rats

Hamani, Clement; Dubiela, Francisco Paulino; Soares, Juliana Carlota Kramer; Shin, Damian S.; Bittencourt, Simone; Covolan, Luciene; Carlen, Peter L.; Laxton, Adrian W.; Hodaie, Mojgan; Stone, Scellig; Ha, Yoon; Hutchison, William D.; Lozano, Andrés M.; Mello, Luiz E.; Oliveira, Maria Gabriela Menezes

doi:10.1016/j.expneurol.2010.06.007

Cited by 79 publications

(42 citation statements)

References 51 publications

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“…Anterior thalamic damage likely causes wide dysfunctions within an extended system (Nelson and Aggleton, 2014), which may compromise the efficient information flow between the hippocampal formation and the cortex necessary for system-level consolidation of contextual fear memory. Similarly, deep brain stimulation of the anterior thalamus induces a deficit in contextual fear conditioning as well as dysfunctions in the hippocampus and the cortical regions connected with the anterior thalamus (Hamani et al, 2010).…”

Section: The Anterior Thalamus As Part Of An Extended Systemmentioning

confidence: 99%

Functional heterogeneity of the limbic thalamus: From hippocampal to cortical functions

Wolff

Alcaraz

Marchand

et al. 2015

Neuroscience & Biobehavioral Reviews

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Section: The Anterior Thalamus As Part Of An Extended Systemmentioning

confidence: 99%

Functional heterogeneity of the limbic thalamus: From hippocampal to cortical functions

Wolff

Alcaraz

Marchand

et al. 2015

Neuroscience & Biobehavioral Reviews

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“…In rats, ANT stimulation at relatively high current disrupted the acquisition of contextual fear conditioning and impaired performance on a spatial alternating task. 32 At settings that impaired behavior, ANT stimulation induced a functional depolarization block nearby the electrode, increased c-Fos expression in cerebral regions projecting to and receiving projections from the ANT, and influenced hippocampal activity. 32 CLINICAL CORRELATIONS Diencephalic amnesia.…”

Section: Effects Of Experimental Ant Lesions and Stimulationmentioning

confidence: 99%

“…The adverse effects of ANT stimulation on memory performance in rats underscore the need for carefully monitoring memory function while selecting stimulation parameters during the clinical evaluation of ANT DBS. 32 In the SANTE trial, participants in the stimulated group were more likely to report depression or memory problems as adverse events, whereas cognition and mood showed no group differences. 48 In contrast, a study on 9 patients showed that ANT DBS was also associated with improvements in both verbal fluency tasks and delayed verbal memory recall and no cognitive decline at 1-year follow-up.…”

Section: Effects Of Experimental Ant Lesions and Stimulationmentioning

confidence: 99%

Anterior nucleus of the thalamus

2013

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The anterior nucleus of thalamus (ANT) is a key component of the hippocampal system for episodic memory. The ANT consist of 3 subnuclei with distinct connectivity with the subicular cortex, retrosplenial cortex, and mammillary bodies. Via its connections with the anterior cingulate and orbitomedial prefrontal cortex, the ANT may also contribute to reciprocal hippocampal-prefrontal interactions involved in emotional and executive functions. As in other thalamic nuclei, neurons of the ANT have 2 different state-dependent patterns of discharge, tonic and burst-firing; some ANT neurons also contribute to propagation of the theta rhythm, which is important for mechanisms of synaptic plasticity of the hippocampal circuit. Clinical and experimental evidence indicate that damage of the ANT or its inputs from the mammillary bodies are primarily responsible for the episodic memory deficit observed in Wernicke-Korsakoff syndrome and thalamic stroke. Experimental models also indicate that the ANT may have a role in the propagation of seizure activity both in absence and in focal seizures. Because of its central connectivity and possible role in propagation of seizure activity, the ANT has become an attractive target for deep brain stimulation (DBS) for treatment of medically refractory epilepsy. The ANT is one of the nuclei preferentially affected in prion disorders, such as fatal familial insomnia, but the relationship between ANT involvement and the clinical manifestations of these disorders remains unclear. The connectivity patterns and electrophysiology of the ANT have been the subject of several reviews.(1-4.)

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“…The procedure for obtaining brain slices and conducting electrophysiology are described elsewhere (Shin et al, 2007;Hamani et al, 2010b). In brief, male Sprague-Dawley rat pups (P23-24) were anesthetized with isoflurane and decapitated.…”

Section: Electrophysiologymentioning

confidence: 99%

Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors

Pushparaj

Hamani

et al. 2012

Neuropsychopharmacol

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Pharmacological inactivation of the granular insular cortex is able to block nicotine-taking and -seeking behaviors in rats. In this study, we explored the potential of modulating activity in the insular region using electrical stimulation. Animals were trained to self-administer nicotine (0.03 mg/kg per infusion) under a fixed ratio-5 (FR-5) schedule of reinforcement followed by a progressive ratio (PR) schedule. Evaluation of the effect of stimulation in the insular region was performed on nicotine self-administration under FR-5 and PR schedules, as well on reinstatement of nicotine-seeking behavior induced by nicotine-associated cues or nicotine-priming injections. The effect of stimulation was also examined in brain slices containing insular neurons. Stimulation significantly attenuated nicotine-taking, under both schedules of reinforcement, as well as nicotine-seeking behavior induced by cues and priming. These effects appear to be specific to nicotine-associated behaviors, as stimulation did not have any effect on food-taking behavior. They appear to be anatomically specific, as stimulation surrounding the insular region had no effect on behavior. Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored.

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Anterior thalamus deep brain stimulation at high current impairs memory in rats

Cited by 79 publications

References 51 publications

Functional heterogeneity of the limbic thalamus: From hippocampal to cortical functions

Functional heterogeneity of the limbic thalamus: From hippocampal to cortical functions

Anterior nucleus of the thalamus

Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors

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