Anterior Uveitis after Collagen Cross-linking for Keratoconus

Purpose. To describe a case of acute anterior uveitis (AAU) with HLA-B27 positivity following epithelium-off corneal cross-linking (CXL) in a patient with a previous intrastromal corneal ring segment. Observations. A 28-year-old male with keratoconus (KCN) developed ophthalmalgia, perilimbal injection, hypopyon, and decline in corrected distance visual acuity (CDVA) 3 days after CXL. A working diagnosis of inflammatory versus infectious AAU was made, and the patient was treated with topical tobramycin, polymyxin B/trimethoprim, prednisolone, and oral valacyclovir. Clinical appearance and CDVA improved, ultimately returning to baseline by two weeks postoperatively. Diagnostic laboratory workup revealed HLA-B27 positivity. Conclusions and Importance. A comprehensive laboratory workup is helpful to identify potential causative and associated systemic conditions when encountering AAU after CXL. Given the overlap in patient demographics for KCN and HLA-B27 positivity, clinicians should consider this entity in the differential diagnosis and treatment of such cases.

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Acute Anterior Uveitis with HLA-B27 Positivity after Corneal Cross-Linking with Previous Intrastromal Corneal Ring Segment

Khan

McGuffey

Melson

et al. 2022

Case Reports in Ophthalmological Medicine

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Reflections on the Controversies on Collagen Corneal Cross-linking for Arresting Keratoconus

2017

International Journal of Keratoconus and Ectatic Corneal Diseases

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Anterior Uveitis after Collagen Cross-linking for Keratoconus

Abstract: This report describes a case of severe intraocular inflammation followed after CXL with UVA and riboflavin treatment for progressive keratoconus.

Cited by 2 publications

References 18 publications

Acute Anterior Uveitis with HLA-B27 Positivity after Corneal Cross-Linking with Previous Intrastromal Corneal Ring Segment

Acute Anterior Uveitis with HLA-B27 Positivity after Corneal Cross-Linking with Previous Intrastromal Corneal Ring Segment

Reflections on the Controversies on Collagen Corneal Cross-linking for Arresting Keratoconus

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