Anterograde tracing of trigeminal afferent pathways from the murine tooth pulp to cortex using herpes simplex virus type 1

Barnett, E. M.; Evans, GD; Sun, Ning; Perlman, Stanley; Cassell,

doi:10.1523/jneurosci.15-04-02972.1995

Cited by 98 publications

(70 citation statements)

References 46 publications

(61 reference statements)

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“…For example, in the present study using H129, we found infection in the ipsilateral DRG beginning at 48 h postinjection, as well as in the ipsilateral T13 sympathetic ganglion. H129 is most useful because of its strictly anterograde travel through neural circuits (6,43,50). The labeling of T13 postganglionic SNS cells may have occurred because they also are first-order neurons, and H129 initially infects all first-order neurons, as was shown with stomach injections of H129 (33).…”

Section: Discussionmentioning

confidence: 94%

“…To this end, we used the H129 strain of the herpes simplex virus-1 (HSV-1), a transneuronal viral tracer that spreads anterogradely (6,17,33,43,50), in contrast to the retrograde of PRV, to trace the multi-synaptic ascending afferent circuit from inguinal WAT (IWAT) or epididymal WAT (EWAT) through the CNS of Siberian hamsters. Immunohistochemical detection of H129 has been previously used in this manner to successfully identify CNS regions that receive viscerosensory inputs from the rat stomach wall (33).…”

mentioning

confidence: 99%

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Anterograde transneuronal viral tract tracing reveals central sensory circuits from white adipose tissue

Song¹,

Schwartz²,

Bartness³

2009

American Journal of Physiology-Regulatory, Integrative and Comp

120

131

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Song CK, Schwartz GJ, Bartness TJ. Anterograde transneuronal viral tract tracing reveals central sensory circuits from white adipose tissue. Am J Physiol Regul Integr Comp Physiol 296: R501-R511, 2009. First published December 24, 2008 doi:10.1152/ajpregu.90786.2008The origins of the sympathetic nervous system (SNS) innervation of white adipose tissue (WAT) have been defined using the transneuronal viral retrograde tract tracer, pseudorabies virus. Activation of this SNS innervation is acknowledged as the principal initiator of WAT lipolysis. The central control of WAT lipolysis may require neural feedback to a brain-SNS-WAT circuit via WAT afferents. Indeed, conventional tract tracing studies have demonstrated that peripheral pseudounipolar dorsal root ganglion (DRG) sensory cells innervate WAT. The central nervous system projections of WAT afferents remain uncharted, however, and form the focus of the present study. We used the H129 strain of the herpes simplex virus-1 (HSV-1), an anterograde transneuronal viral tract tracer, to define the afferent circuits projecting from WAT to the central nervous system. Siberian hamster inguinal (IWAT) or epididymal WAT was injected with H129 and the neuraxis processed for HSV-1 immunoreactivity. We found substantial overlap in the pattern of WAT sensory afferent projections with multiple SNS outflow sites along the neuraxis, suggesting the possibility of WAT sensory-SNS circuits that could regulate WAT SNS drive and thereby lipolysis. Previously, we demonstrated that systemic 2-deoxy-D-glucose (2DG) elicited increases in the SNS drive to IWAT. Here, we show that systemic 2DG administration also significantly increases multiunit spike activity arising from decentralized IWAT afferents. Collectively, these data provide structural and functional support for the existence of a sensory WAT pathway to the brain, important in the negative feedback control of lipid mobilization.2-deoxy-D-glucose; lipolysis; sympathetic nervous system; electrophysiology FEEDBACK FROM LIPID STORES to the central nervous system (CNS) has been suggested to contribute to the relative stability of total body fat in some individuals, but not in others (for a review, see Ref. 1). Historically, the idea of a lipid feedback signal became prominent with Kennedy's "lipostatic theory" (24), and this notion apparently was affirmed with the discovery of leptin, the largely adipocyte-derived cytokine thought by some to reflect total body fat stores (for a review, see Ref. 21). As with any feedback system, one controlling lipid stores would require not only afferent signals from white adipose tissue (WAT), but also effectors to increase or decrease the lipid stores appropriately. As with any feedback system, one controlling lipid stores would require not only afferent signals from WAT, but also effectors to increase or decrease the lipid stores appropriately. Whether such a system exists or needs to exist for total body fat to be stable is debatable (46). Efferent neural control of WAT is well recognized. We and...

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Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 99%

Anterograde transneuronal viral tract tracing reveals central sensory circuits from white adipose tissue

Song¹,

Schwartz²,

Bartness³

2009

American Journal of Physiology-Regulatory, Integrative and Comp

120

131

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“…The cutaneous small-diameter afferents terminate extensively in the subnucleus caudalis and caudal interpolaris (Gobel et al, 1981;Hayashi, 1985;Jacquin et al, 1988), although there are some data suggesting that some might terminate further rostrally in the VBSNC (Falls, 1988;Sugimoto et al, 1997b; and see Section V). Moreover, primary afferents from the tooth pulp, which is primarily innervated by small-diameter afferents (see Sessle, 1987;Narhi et al, 1994), have been reported in both electrophysiological and anatomical investigations to terminate in great numbers in rostral as well as caudal components of the VBSNC (Tsuru et al, 1989;Hu et al, 1992b;Takemura et al, 1993;Barnett et al, 1995;and see Sessle, 1987).…”

Section: Trigeminal Brainstem Sensory Nuclear Complexmentioning

confidence: 99%

Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates

Sessle

2000

Critical Reviews in Oral Biology & Medicine

614

541

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This paper reviews the recent advances in knowledge of brainstem mechanisms related to craniofacial pain. It also draws attention to their clinical implications, and concludes with a brief overview and suggestions for future research directions. It first describes the general organizational features of the trigeminal brainstem sensory nuclear complex (VBSNC), including its input and output properties and intrinsic characteristics that are commensurate with its strategic role as the major brainstem relay of many types of somatosensory information derived from the face and mouth. The VBSNC plays a crucial role in craniofacial nociceptive transmission, as evidenced by clinical, behavioral, morphological, and electrophysiological data that have been especially derived from studies of the relay of cutaneous nociceptive afferent inputs through the subnucleus caudalis of the VBSNC. The recent literature, however, indicates that some fundamental differences exist in the processing of cutaneous vs. other craniofacial nociceptive inputs to the VBSNC, and that rostral components of the VBSNC may also play important roles in some of these processes. Modulatory mechanisms are also highlighted, including the neurochemical substrate by which nociceptive transmission in the VBSNC can be modulated. In addition, the long-term consequences of peripheral injury and inflammation and, in particular, the neuroplastic changes that can be induced in the VBSNC are emphasized in view of the likely role that central sensitization, as well as peripheral sensitization, can play in acute and chronic pain. The recent findings also provide new insights into craniofacial pain behavior and are particularly relevant to many approaches currently in use for the management of pain and to the development of new diagnostic and therapeutic procedures aimed at manipulating peripheral inputs and central processes underlying nociceptive transmission and its control within the VBSNC.

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“…1), anterior and dorsal to areas receiving visceral and nociceptive inputs (Cechetto and Saper, 1987;Barnett et al, 1995). The MCA and the RHVs provide anatomical landmarks helping to locate precisely the GC (Yamamoto et al, 1985;Kosar et al, 1986).…”

Section: Functional Localization Of the Gcmentioning

confidence: 99%

Differential Spatial Representation of Taste Modalities in the Rat Gustatory Cortex

Accolla¹,

Bathellier²,

Petersen³

et al. 2007

J. Neurosci.

179

175

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Discrimination between foods is crucial for the nutrition and survival of animals. Remarkable progress has been made through molecular and genetic manipulations in the understanding of the coding of taste at the receptor level. However, much less is known about the cortical processing of taste sensation and the organizing principles of the gustatory cortex (GC). Using genetic tracing, it has recently been shown that sweet and bitter taste are processed through segregated neuronal circuitries along the gustatory pathway up to the cortical level. This is in disagreement with the evidence that GC neurons recorded in both anesthetized and behaving animals responded to multiple taste modalities (including sweet and bitter). To investigate the functional architecture of the GC in regard to taste modalities, we used in vivo intrinsic optical imaging, a technique that has been successfully applied to explore the organization of other neocortical regions. We found that four of the primary taste modalities (sweet, bitter, salty, and sour) are represented by distinctive spatial patterns but that no region was specific to a single modality. In addition, we found that two tastants of similar hedonic value (pleasant or unpleasant) activated areas with more common regions than two tastants with opposite hedonic value. In summary, we propose that these specific cortical patterns can be used to discriminate among various tastants.

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Anterograde tracing of trigeminal afferent pathways from the murine tooth pulp to cortex using herpes simplex virus type 1

Cited by 98 publications

References 46 publications

Anterograde transneuronal viral tract tracing reveals central sensory circuits from white adipose tissue

Anterograde transneuronal viral tract tracing reveals central sensory circuits from white adipose tissue

Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates

Differential Spatial Representation of Taste Modalities in the Rat Gustatory Cortex

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