Anterolateral meningioma of the foramen magnum and high cervical spine presenting intradural and extradural growth in a child: case report and literature review

Athanasiou, Alkinoos; Magras, Ioannis; Sarlis, Panagiotis; Spyridopoulos, Evangelos; Polyzoidis, Konstantinos S.

doi:10.1007/s00381-015-2784-5

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…In our series 6 patients had multiple meningiomas. In many cases documented in the literature, multiplicity was wholly accounted for by a concurrent diagnosis of NF2 3,34,43 as patients with NF2 are known to be at risk for multiple CNS tumors (not only meningioma). However, multiplicity has been reported in association with radiation-induced meningioma 4,18 and in sporadic meningioma in children.…”

Section: Discussionmentioning

confidence: 99%

Pediatric meningiomas: 65-year experience at a single institution

Grossbach

Mahaney

Menezes

2017

Journal of Neurosurgery: Pediatrics

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OBJECTIVEMeningiomas are relatively common, typically benign neoplasms in adults; however, they are relatively rare in the pediatric population. Pediatric meningiomas behave very differently from their adult counterparts, tending to have more malignant histological subtypes and recur more frequently. The authors of this paper investigate the risk factors, pathological subtypes, and recurrence rates of pediatric meningiomas.METHODSA retrospective chart review was conducted at the University of Iowa to identify patients 20 years old and younger with meningiomas in the period from 1948 to 2015.RESULTSSixty-seven meningiomas in 39 patients were identified. Eight patients had neurofibromatosis, 2 had a family history of meningioma, and 3 had prior radiation exposure. Twelve (31%) of the 39 patients had WHO Grade II or III lesions, and 15 (38%) had recurrent lesions after resection.CONCLUSIONSPediatric meningiomas should be considered for early treatment and diligent follow-up.

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Section: Discussionmentioning

confidence: 99%

Pediatric meningiomas: 65-year experience at a single institution

Grossbach

Mahaney

Menezes

2017

Journal of Neurosurgery: Pediatrics

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“…The literature reports several tumor resection approaches, including posterior petrosal, translabyrinthine, retrosigmoid, transcochlear, retrolabyrinthine, transjugular, and transcondylar [ 5 , 22 , 23 ]. The posterior petrosal technique was found to preserve auditory and facial nerve function in pediatric meningiomas [ 24 ]. The transcochlear passage is associated with a higher risk of facial palsy due to intraoperative complications compared with translabyrinthine or retrosigmoid approaches [ 5 ].…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Overview of Pediatric Neoplasms at the Craniocervical Junction: Meningiomas, Schwannomas, and Chordomas

Jarrah¹,

Shields²,

Durrani³

et al. 2022

Cureus

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Tumors of the craniocervical junction (CCJ) are complicated pathologies with high patient mortality or low quality of life. In the pediatric population, these tumors are less prevalent, with various symptomatic presentations that include motor and neurological manifestations. Three of the most common neoplasms at the CCJ in children are meningiomas, schwannomas, and chordomas. In this review, we will characterize the tissue biomarkers, clinical presentation, treatment methods, and surgical outcomes for these pediatric tumors at the CCJ. A comprehensive literature review was used using the PubMed Database. Keywords used were "craniocervical junction", "pediatric", "meningiomas", schwannomas", and "meningiomas". Articles that were not related to the CCJ, included only adult cases, and non-English studies were filtered. Our search yielded a total of 11 studies, with a total of 239 pediatric patients with tumors at the CCJ. These studies were broken down as five for meningiomas, one for schwannomas, and eight for chordomas. In conclusion, resection of pediatric neoplasms at the CCJ is challenging due to anatomical limitations and the size of the patient. Within the CCJ, chordomas were the most prevalent tumor type, with schwannomas being the least prevalent. Literature findings indicate that genetic mutations of the NF2 gene associated with neurofibromatosis type II, as well as incomplete tumor resection, are predictors of poor outcomes. Further developments of monoclonal antibody chemotherapy and endoscopic approaches could expand treatment options for aggressive pediatric neoplasms at the skull base.

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