Anterolateral Thigh Flap

Lubek, Joshua E.; Engroff, Stephen L.

doi:10.1016/b978-1-4160-2527-6.00071-2

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…The PAI-03 system ability to unravel the vascular anatomy of the thigh was explored in [63]. The system was used to identify anterolateral thigh perforators [64] and the branching patterns in the subcutaneous layer. The study included 5 patients in a registered clinical trial (UMIN000018893).…”

Section: Cardio-vascular Imagingmentioning

confidence: 99%

A Review on Clinical Optoacoustic Imaging: Are We Close to Clinical Adoption?

Contador,

Ripoll,

Lage

et al. 2024

Preprint

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Optoacoustic imaging is an emerging technology that holds great promise for improving general clinical practice since it offers a unique combination of optical absorption contrast, high resolution, and high penetration depth. This combination of factors provides a distinct advantage over alternative imaging modalities in oncology, cardiology, dermatology, or endocrinology among other medical fields. Optoacoustic technology affords the medical practitioner the possibility of visualizing light-absorbing biomolecules like water, lipids, oxy/deoxy hemoglobin, or melanin in deep tissue with relatively cheap and small form factor instruments, without the need of contrast agents or ionizing radiation. Moreover, exogenous fluorescent contrast agents like indocyanine green or methylene blue can also be observed. Driven by its potential for new applications in the clinic, the field has experienced intense changes in the last 20 years. Continuous technological advancements in instrumentation, image formation methods, or acquisition geometries, have led to the development of numerous clinical devices also motivating the creation of several startup companies that aim to translate the technology from the lab to the clinic. Thus, the question arises: how far are we from clinical adoption? In this article, we aim to shed light on such question by reviewing the clinical studies that have been performed in the last 10 years. Our intention is to go beyond the classical review format by providing a brief general overview of the steps that new imaging methods undergo on their journey from the lab to clinical adoption. Then we examine the progress that optoacoustic technology has made on such a journey.

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Section: Cardio-vascular Imagingmentioning

confidence: 99%

A Review on Clinical Optoacoustic Imaging: Are We Close to Clinical Adoption?

Contador,

Ripoll,

Lage

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Consequently, this constrains the mass production of such grafts and their application to vessels over 3 mm in diameter, e.g. the radial artery, superior epigastric artery, and lateral circumflex femoral artery; the diameters and lengths of such arteries range from 0.7 to 3.3 mm and 2.2 to 24.7 cm, respectively [28][29][30][31][32][33]. In recent years, three-dimensional (3D) bioprinting has been utilised to produce large-diameter vascular grafts using biomaterials and living cells [34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Double-layered blood vessels over 3 mm in diameter extruded by the inverse-gravity technique

Duong,

Nguyen,

Phan

et al. 2023

Biofabrication

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One of the most promising techniques for treating severe peripheral artery disease is the use of cellular tissue-engineered vascular grafts (TEVGs). This study proposes an inverse-gravity (IG) extrusion technique for creating long double-layered cellular TEVGs with diameters over 3 mm. A three-layered coaxial laminar hydrogel flow in an 8 mm-diameter pipe was realized simply by changing the extrusion direction of the hydrogel from being aligned with the direction of gravity to against it. This technique produced an extruded mixture of human aortic smooth muscle cells (HASMCs) and Type-I collagen as a tubular structure with an inner diameter of 3.5 mm. After a 21-day maturation period, the maximal burst pressure, longitudinal breaking force, and circumferential breaking force of the HASMC TEVG were 416 mmHg, 0.69 N, and 0.89 N, respectively. The HASMC TEVG was endothelialized with human umbilical vein endothelial cells to form a tunica intima that simulated human vessels. Besides subcutaneous implantability on mice, the double-layered blood vessels showed a considerably lower adherence of platelets and red blood cells once exposed to heparinized mouse blood and were considered nonhemolytic. The proposed IG extrusion technique can be applied in various fields requiring multilayered materials with large diameters.

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Anterolateral Thigh Flap

Cited by 2 publications

References 32 publications

A Review on Clinical Optoacoustic Imaging: Are We Close to Clinical Adoption?

A Review on Clinical Optoacoustic Imaging: Are We Close to Clinical Adoption?

Double-layered blood vessels over 3 mm in diameter extruded by the inverse-gravity technique

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