Anthelmintic activity of crude powder and crude aqueous extract of Trachyspermum ammi on gastrointestinal nematodes in donkey (Equus asinus): An in vivo study

Imani-Baran, Abbas; Abdollahi, J.; Akbarī, Ḥamīd; Jafarirad, Saeed; Moharramnejad, Sajjad

doi:10.1016/j.jep.2019.112249

Cited by 17 publications

(16 citation statements)

References 48 publications

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“…eggs,” Strongylus spp. larvae,” “cyathostomins eggs” and “cyathostomins larvae.” Infection rates between 4.4 and 69.2% in horses [ 35 – 37 , 114 – 127 ], 65.4 and 96.4% in four studies on donkeys [ 36 , 117 , 128 , 129 ] and 80% in the only study on mules [ 117 ] have been reported.…”

Section: Helminthosesmentioning

confidence: 99%

“…Infection of horses with Parascaris spp. is a common infection in equids, and prevalences of 12.2–40.0% in horses [ 35 , 36 , 115 , 116 , 118 , 121 – 126 , 133 , 136 , 147 , 148 ] and 3.8–20.0% in three studies on donkeys [ 36 , 117 , 129 ] have been reported. Karyotyping of Parascaris spp.…”

Section: Helminthosesmentioning

confidence: 99%

“…Adult S . westeri nematodes in horses [ 115 ] and eggs or larvae in feces of horses [ 125 , 167 ] and donkeys have been reported in Iran [ 129 , 148 ].…”

Section: Helminthosesmentioning

confidence: 99%

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Parasitic diseases of equids in Iran (1931–2020): a literature review

et al. 2020

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Parasitic infections can cause many respiratory, digestive and other diseases and contribute to some performance conditions in equids. However, knowledge on the biodiversity of parasites of equids in Iran is still limited. The present review covers all the information about parasitic diseases of horses, donkeys, mules and wild asses in Iran published as articles in Iranian and international journals, dissertations and congress papers from 1931 to July 2020. Parasites so far described in Iranian equids include species of 9 genera of the Protozoa (Trypanosoma, Giardia, Eimeria, Klossiella, Cryptosporidium, Toxoplasma, Neospora, Theileria and Babesia), 50 helminth species from the digestive system (i.e., 2 trematodes, 3 cestodes and 37 nematodes) and from other organs (i.e., Schistosoma turkestanica, Echinococcus granulosus, Dictyocaulus arnfieldi, Parafilaria multipapillosa, Setaria equina and 3 Onchocerca spp.). Furthermore, 16 species of hard ticks, 3 mite species causing mange, 2 lice species, and larvae of 4 Gastrophilus species and Hippobosca equina have been reported from equids in Iran. Archeoparasitological findings in coprolites of equids include Fasciola hepatica, Oxyuris equi, Anoplocephala spp. and intestinal strongyles. Parasitic diseases are important issues in terms of animal welfare, economics and public health; however, parasites and parasitic diseases of equines have not received adequate attention compared with ruminants and camels in Iran. The present review highlights the knowledge gaps related to equines about the presence, species, genotypes and subtypes of Neospora hughesi, Sarcocystis spp., Trichinella spp., Cryptosporidium spp., Giardia duodenalis, Blastocystis and microsporidia. Identification of ticks vectoring pathogenic parasites, bacteria and viruses has received little attention, too. The efficacy of common horse wormers also needs to be evaluated systematically.

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Section: Helminthosesmentioning

confidence: 99%

Section: Helminthosesmentioning

confidence: 99%

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Parasitic diseases of equids in Iran (1931–2020): a literature review

et al. 2020

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“…(2019) reported that saponins and prosapogenins possess strong ovicidal activity against donkey GI nematodes, showing >80% inhibition of egg hatching. Crude aqueous extract of Trachyspermum ammi has shown good in vivo anthelmintic activity against donkey GI nematodes, the faecal egg count reduction being 71.2% (Imani-Baran et al ., 2020). However, a herbal dewormer commercially available in Italy, which contains Mallotus philippinensis , Carduus marianus , Urtica urens , Genziana lutea and Eucalyptus globulus extracts, failed to exhibit any anthelmintic effect in vivo in donkeys – proof that in vitro and in vivo studies of the medicinal plants before their administration are required (Papini et al ., 2020).…”

Section: Introductionmentioning

confidence: 99%

In vitro anthelmintic activity assessment of six medicinal plant aqueous extracts against donkey strongyles

et al. 2020

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The lack of anthelmintic products licensed for donkeys and the rising number of small donkey milk farms in the countries of Western Europe and Italy have led to an increased interest in the study of reliable and safe plant-derived treatment alternatives. In this study, the aqueous extracts of Achillea millefolium L. (flowers), Artemisia absinthium L. (aerial parts), Centaurium erythraea Rafn. (flowers), Gentiana asclepiadea L. (rhizomes and roots), Inula helenium L. (rhizomes and roots) and Tanacetum vulgare L. (aerial parts), have been tested in vitro for their potential ovicidal and larvicidal activity against donkey nematodes. An egg-hatching assay (EHA) and larval development assay (LDA) were performed for the in vitro study, and median lethal concentration (LC-50) values for both EHA and LDA were calculated using probit analysis. All tested plant extracts showed strong anthelmintic activity against strongyle eggs and larvae at concentrations ranging between 125 and 1.95 mg/ml, except for C. erythraea, which exhibited very little or no effect at all at the tested concentrations. A strong ovicidal effect was observed in A. absinthium, with an LC-50 value of 0.486 mg/ml (95% confidence interval (CI) 0.21–1.09). Gentiana asclepiadea showed high efficacy against strongyle larvae, with an LC-50 value of 0.041 mg/ml (95% CI 0.01–0.16). The most significant (P < 0.01) anthelmintic activity was exhibited by I. helenium, with an LC-50 value of 0.041 mg/ml (95% CI 0.01–0.16) for EHA and 0.41 mg/ml (95% CI 0.27–0.62) for LDA. The results proved the anthelmintic efficacy of the tested plant extracts, highlighting the need for further research into plant bioactive molecules both in vitro and in vivo.

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“…Bunium persicum and its derivatives have reported multi-pharmacological effects, including antimicrobial, antioxidant, anti-in ammatory, Antinociceptive, antidiabetic, antifungal and antibacterial [13][14][15][16][17][18]. Trachyspermum ammi has impressive biological and pharmacological properties, including antimicrobial, antihyperlipidemic, anthelmintic, antibacterial and insecticidal activities [19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of nano-liposomes containing Bunium persicum and Trachyspermum ammi essential oils against Trichomonas vaginalis

Mirzaei

Norouzi

Siyadatpanah

et al. 2020

Preprint

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Background: Trichomonas vaginalis, a parasitic flagellated protozoan, is one of the main non-viral sexually-transmitted diseases worldwide. Treatment options for trichomoniasis are limited to nitroimidazole compounds. However, resistance to these drugs has been reported, which requires the development of new anti-Trichomonas agents that confer suitable efficacy and less toxicity.Methods: In the present work, we assessed the effectiveness of the liposomal system containing essential oils of Bunium persicum and Trachyspermum ammi against T. vaginalis in vitro. Liposomal vesicles were prepared with phosphatidylcholine (70%) and cholesterol (30%) using the thin-film method. The essential oils of B. persicum and T. ammi were loaded into the liposomes using the inactive loading method. Liposomal vesicles were made for two plants separately. Their physicochemical features were tested using Zeta-Sizer, AFM and SEM. The anti-Trichomonas activity was determined after 12 and 24 hours of parasite cultures in TYI-S-33 medium. Results: After 12 and 24 hours of administration, the IC50 of the B. persicum essential oil nano-liposomes induced 14.41 µg/mL and 45.19 µg/mL, respectively. The IC50 of T. ammi essential oil nano-liposomes induced 8.08 µg/mL and 25.81 µg/mL, respectively. Conclusions: These data suggested that nano-liposomes of the essential oils of B. persicum and T. ammi may be a promising alternative to current treatments for Trichomonas infection.

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Anthelmintic activity of crude powder and crude aqueous extract of Trachyspermum ammi on gastrointestinal nematodes in donkey (Equus asinus): An in vivo study

Cited by 17 publications

References 48 publications

Parasitic diseases of equids in Iran (1931–2020): a literature review

Parasitic diseases of equids in Iran (1931–2020): a literature review

In vitro anthelmintic activity assessment of six medicinal plant aqueous extracts against donkey strongyles

Green synthesis of nano-liposomes containing Bunium persicum and Trachyspermum ammi essential oils against Trichomonas vaginalis

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