Anthelmintic activity of mitomycins A, C, and F against hymenolepidid larvae in Tribolium confusum

Abstract

Mitomycin analogues were tested against metacestode stages of Hymenolepis microstoma and H. nana developing in Tribolium confusum. The effects of the mitomycins varied according to both the drug and the species of the parasite. In general, the most effective compound was mitomycin C, followed by mitomycin A and then by mitomycin F. The efficacy of drugs improved further when sodium bicarbonate was added to the diet.

Aziridine alkaloids as potential therapeutic agents

“…Mitomycin J (35) and mitomycin D (36) were isolated as minor antibiotics from Streptomyces fradiae SCF5 [95], and mitomycin E (37) was obtained from Streptomyces lavendulae [96]. Mitomycin C, A and F showed anthelmintic activity against gastro-intestinal parasites Hymenolepis microstoma and Hymenolepis nana developing in Tribolium confusum (Coleoptera, Tenebrionidae) [97].…”

“…Mitomycins H, G, K, and Z (51) were also prepared from mitomycin B by cultivating Streptomyces caespitosus ATCC 27422 [97]. Four isolated antibiotics (48-51) possessed antibacterial activity [100].…”

“…Fatty acid derivatives (97)(98)(99)(100)(101) containing an internal aziridine group were prepared by reaction of base with Me iodocarbamates obtained by addition of INCO to a natural fatty acid derivative followed by treatment with MeOH [142]. Preparation of epiminostearates (97) has also been reported [143].…”