Anthelmintic Agents

Lappin, Michael R.

doi:10.1016/b978-1-4160-3661-6.00037-7

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Moreover, the discovery of amino-adamantane derivatives with enhanced trypanocidal activity (27) has spurred efforts for the development of more potent adamantane-benzene derived trypanocidal agents (28). Piperazine-based anti-helminthic drugs (29) have also gained interest in drug design studies because of their trypanocidal activity (30).…”

Section: Hts Design and Image Analysismentioning

confidence: 99%

A novel high-content phenotypic screen to identify inhibitors of mitochondrial DNA maintenance in trypanosomes

Miskinyte

Dawson

Makda

et al. 2020

Preprint

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Kinetoplastid parasites cause diverse neglected diseases in humans and livestock, with an urgent need for new treatments. Survival of kinetoplastids depends on their uniquely structured mitochondrial genome (kDNA), the eponymous kinetoplast. Here we report development of a high-content screen for pharmacologically induced kDNA loss, based on specific staining of parasites and automated image analysis. As proof-of-concept we screened a diverse set of ~14,000 small molecules and exemplify a validated hit as a novel kDNA-targeting compound.

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Section: Hts Design and Image Analysismentioning

confidence: 99%

A novel high-content phenotypic screen to identify inhibitors of mitochondrial DNA maintenance in trypanosomes

Miskinyte

Dawson

Makda

et al. 2020

Preprint

View full text Add to dashboard Cite

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A Novel High-Content Phenotypic Screen To Identify Inhibitors of Mitochondrial DNA Maintenance in Trypanosomes

Miskinyte

Dawson

Makda

et al. 2022

Antimicrob Agents Chemother

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Kinetoplastid parasites cause diverse neglected diseases in humans and livestock, with an urgent need for new treatments. Survival of kinetoplastids depends on their uniquely structured mitochondrial genome (kDNA), the eponymous kinetoplast. Here we report development of a high-content screen for pharmacologically induced kDNA loss, based on specific staining of parasites and automated image analysis. As proof-of-concept we screened a diverse set of ∼14,000 small molecules and exemplify a validated hit as a novel kDNA-targeting compound.

show abstract

Anthelmintic Agents

Cited by 2 publications

References 28 publications

A novel high-content phenotypic screen to identify inhibitors of mitochondrial DNA maintenance in trypanosomes

A novel high-content phenotypic screen to identify inhibitors of mitochondrial DNA maintenance in trypanosomes

A Novel High-Content Phenotypic Screen To Identify Inhibitors of Mitochondrial DNA Maintenance in Trypanosomes

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