Anthelmintic effects and toxicity of Cynodon dactylon (L.) Pers. in rodent models

Yadav, Arun K.; Nath, Purobi

doi:10.5455/jice.20170810024110

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…In turn, S. mansoni infected mice treated orally with a methanol extract of C. ambrosioides (1250 mg/kg/day) exhibited a 53.7% total worm burden decrease and a 60.3% ova/g tissue in liver reduction, 9 weeks post-infection [ 86 ]. Hymenolepis diminuta infected Wistar rats were treated with C. dactylon methanol extract (800 mg/kg) enabling a reduction of 77.6% in eggs and 79% in adult worms counts, respectively [ 83 ].…”

Section: Halophyte Plants As Sources Of Anthelmintic Agentsmentioning

confidence: 99%

Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review

et al. 2023

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Parasitic diseases, especially those caused by protozoans and helminths, such as malaria, trypanosomiasis, leishmaniasis, Chagas disease, schistosomiasis, onchocerciasis, and lymphatic filariasis, are the cause of millions of morbidities and deaths every year, mainly in tropical regions. Nature has always provided valuable antiparasitic agents, and efforts targeting the identification of antiparasitic drugs from plants have mainly focused on glycophytes. However, salt-tolerant plants (halophytes) have lately attracted the interest of the scientific community due to their medicinal assets, which include antiparasitic properties. This review paper gathers the most relevant information on antiparasitic properties of halophyte plants, targeting human uses. It includes an introduction section containing a summary of some of the most pertinent characteristics of halophytes, followed by information regarding the ethnomedicinal uses of several species towards human parasitic diseases. Then, information is provided related to the antiprotozoal and anthelmintic properties of halophytes, determined by in vitro and in vivo methods, and with the bioactive metabolites that may be related to such properties. Finally, a conclusion section is presented, addressing perspectives for the sustainable exploitation of selected species.

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Section: Halophyte Plants As Sources Of Anthelmintic Agentsmentioning

confidence: 99%

Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review

et al. 2023

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“…Also, the treatment of rats by a dose of 800 mg/mL/kg for five days caused a reduction of 77.64% and 79.00% in the number of eggs per gram of feces and the worm load, respectively, after the treatment with Cynodon dactylon. 47…”

Section: The Use Of Herbs For Hymenolepis Diminutamentioning

confidence: 99%

A review of the effect of medicinal plant on helminthic infections

Khamesipour

Kheyri

Shojaat

et al. 2021

Infect Dis Herbal Med

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Nowadays, parasitic worm infection is one of the most critical global health problems. Worm infections cause severe detriments to the livestock industry and also it can cause irreparable damages to immunocompromised persons. Therefore, the present study aimed to review conducted research on the treatment of worm diseases using medicinal plants’ extract. In this systematic review, seven databases including 4 English (Scopus, PubMed, ScienceDirect, Google Scholar) and 3 Persian databases (Magiran, ISC, SID) were obtained between 2008 and 2020 to evaluate conducted studies related to the aim of the current review. Most of the studies focused on the Balanites aegyptiaca and Carica papaya plant. Water was the most common solvent (38.1%) and then it was methanol. The most studied parasite was Haemonchus contortus (35.5%), followed by Aacharidia galli (10.5%). Studies showed that plant extracts could reduce effect of worm infections in the host compared to synthetic drugs. Plant extracts can produce a medicine based on natural compounds and effective on worms with fewer side effects than synthetic drugs.

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“…In endemic areas, these infections are treated periodically with anthelmintic medicines. Piperazine hydrochloride, albendazole, mebendazole, ivermectin and levamisole are the approved drugs widely used to treat human and animal parasites ( Yadav et al ., 2017 ). For example, albendazole inhibits parasite microtubule polymerization by binding to the β-tubulin.…”

Section: Introductionmentioning

confidence: 99%

Exploring the anthelmintic activity of Olea europaea L (Olive) leaves extract and oleuropein in mice naturally infected with Aspiculuris tetraptera

Kamran,

Yildirimhan,

Şenlik

2023

Helminthologia

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Summary Oxyuriasis, caused by the nematode Enterobius vermicularis, is one of the cosmopolitan intestinal infections of humans. Aspiculuris tetraptera commonly infects mice and it is morphologically similar to E. vermicularis. Parasitic resistance reduces the efficiency of synthetic drugs and poses economic impacts on the dairy sector, thus necessitating novel anthelmintic agents. Olea europaea L. (Olive) is a bioactive plant with potent pharmacological activities. However, its effects on oxyurids are poorly known, and no studies are currently exploring olives’ anthelmintic potential. In this study, we investigated the pharmacokinetic behaviors of O. europaea leaves extract (OLE) and its phenolic compound oleuropein in mice infected with A. tetraptera, in comparison with Albendazole (ABZ), a standard drug used to treat parasitic worms. Fecal flotation method was used to identify the infestation with A. tetraptera eggs by examining the stool samples from mice. Infected animals were divided into 7 groups. 250 mg/kg, 500 mg/kg, and 1000 mg/kg doses of OLE, 5 mg/kg and 20 mg/kg doses of oleuropein, 10 mg/kg of ABZ and tap water were orally administered by gavage for 7 days during treatments. Drug efficacies and statistical differences between the treatments and controls were evaluated. Our results revealed 92.43 % efficacy of ABZ, similar to 92.19 % efficacy of 1000 mg/kg of OLE. At the same time, 250 mg/kg and 500 mg/kg concentrations of OLE remained 70.03 % and 63.18 % effective in reducing worm counts. Efficacy percentages of 5 mg/kg and 20 mg/kg of oleuropein were 9.27 % and 70.56 %, respectively. Statistical analysis of ABZ was significant compared to 1000 mg/kg of OLE, which was almost equal but insignificant. In general, our results confirm the anthelmintic potential of OLE and oleuropein against mice pinworms and open the way for targeted extraction of bioactive compounds from plants to optimize its use in human and veterinary medicine.

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Anthelmintic effects and toxicity of Cynodon dactylon (L.) Pers. in rodent models

Cited by 6 publications

References 18 publications

Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review

Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review

A review of the effect of medicinal plant on helminthic infections

Exploring the anthelmintic activity of Olea europaea L (Olive) leaves extract and oleuropein in mice naturally infected with Aspiculuris tetraptera

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