Anthelmintic resistance by Haemonchus contortus to ivermectin in Brazil: a preliminary report

Echevarria, F. A. M.; Trindade, G.N.P.

doi:10.1136/vr.124.6.147

Cited by 83 publications

(26 citation statements)

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“…Média da redução do número de ovos por grama de fezes (OPG) de nematóides gastrintestinais e percentual médio fezes (OPG) de nematóides gastrintestinais e percentual médio fezes (OPG) de nematóides gastrintestinais e percentual médio fezes (OPG) de nematóides gastrintestinais e percentual médio fezes (OPG) de nematóides gastrintestinais e percentual médio da eficácia de drogas anti-helmínticas em caprinos fêmeas na da eficácia de drogas anti-helmínticas em caprinos fêmeas na da eficácia de drogas anti-helmínticas em caprinos fêmeas na da eficácia de drogas anti-helmínticas em caprinos fêmeas na da eficácia de drogas anti-helmínticas em caprinos fêmeas na mesorregião do Sertão P mesorregião do Sertão P mesorregião do Sertão P mesorregião do Sertão P mesorregião do Sertão Paraibano em diferentes períodos de araibano em diferentes períodos de araibano em diferentes períodos de araibano em diferentes períodos de araibano em diferentes períodos de obser obser obser obser observação vação vação vação vação (Melo et al 1998, Vieira & Cavalcante 1999, no nordeste brasileiro (Barreto & Silva 1999). Provavelmente, esses nematóides desenvolvem resistência mais rápida, devido ao seu alto potencial biótico (Echevarria & Trindade 1989).…”

Section: Resul Resul Resul Resul Results T T T Tados E Discus Ados E Dunclassified

Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do Sertão Paraibano

Rodrigues

Athayde²,

Rodrigues³

et al. 2007

Pesq. Vet. Bras.

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Evalu-Evalu-EvaluEvalu-Evaluation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats raised in the state of P raised in the state of P raised in the state of P raised in the state of P raised in the state of Paraíba araíba araíba araíba araíba.] Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do sertão paraibano. Pesquisa Veterinária Brasileira 27 (4) The objective was to evaluate conventional and alternative anthelminthic action on the sensibility of gastrointestinal nematodes in goats. Hundred and twenty goats of both sexes were distributed into 10 groups of 24 animals each (12 males and 12 females) and submitted to treatments of specific anthelminthic composition. The commercial drugs used were moxidectin 0.2%, albendazole, levamisol chlorhydrate, ivermectin and an aqueous extract of the purgative potato (Operculina hamiltonii). The reduction test was applied through egg counts per gram of feces and larval culture to evaluate resistance. The fecal samples were collected in the day when medication was accomplished (day base), at 7, 14 and 21 days after treatment. The following results for the reduction of Trichostrongyloidea eggs were obtained: Treatment of the females with Moxidectina reduced the egg counts to 92.8, 88.7 and 89.8%, of the males to 92.6, 96.2 and 98.1%; with Levamisol of the females to 96, 97.1 and 91%, of the males to 85.7, 94,2 and 100%; with Albendazol of the females 65, 60.3 and 75.4%, of the males 88.8, 88.8 and 55.5%; with Ivermectin of the females to 92.2, 68.6 and 70.6%, of the males to 41.7, 73.6 and 59.7%; and with the purgative potato of the females to 31.8, 34.1 and 49.4%, of the males to 61.5, 80.7 and 50%. In larval culture Haemonchus, followed by Bunostomum, Trichostrongylus, and Oesophagostomum, were identified even after treatments.

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Section: Resul Resul Resul Resul Results T T T Tados E Discus Ados E Dunclassified

Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do Sertão Paraibano

Rodrigues

Athayde²,

Rodrigues³

et al. 2007

Pesq. Vet. Bras.

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“…The highest effectiveness rates of ivermectin in goats in recent years were also found in the Northeast, in the states of CE and RN, respectively, by Melo et al (2003) and Coelho et al (2010). Brazil's southern region, which pioneered reports on AHR to ivermectin (ECHEVARRIA & TRINDADE, 1989), showed the highest effectiveness rate of the drug until the late 1990s (AMARANTE et al, 1992;ECHEVARRIA et al, 1996;FARIAS et al, 1997). Since that period, the low effectiveness of ivermectin in small ruminants has been reported frequently (RAMOS et al, 2002;MATTOS et al, 2004;THOMAZ-SOCCOL et al, 2004;CEZAR et al, 2010;CUNHA et al, 2008;VILA NOVA et al, 2014), and the same applies to the southeast region (CRUZ et al, 2010;ALMEIDA et al, 2010;VERÍSSIMO et al, 2012;CHAGAS et al, 2013).…”

Section: Developments In Research and The Effectiveness Of Anthelmintmentioning

confidence: 90%

“…In the 1980s, macrocyclic lactones with endectocide activity were launched on the French market (CHABALA et al, 1980), and were soon thereafter launched in Brazil in various formulations and concentrations. The first report of loss of ivermectin effectiveness in sheep was published in South Africa (CARMICHAEL et al, 1987), and was soon followed by reports in Brazil (ECHEVARRIA & TRINDADE, 1989). In Brazil, the first report of ivermectin resistance in goats dates from the 1990s in the state of Rio Grande do Sul (MATTOS et al, 1997cited by MATTOS et al, 2004.…”

Section: History Of Ahr In Small Ruminants In Brazil and Around The Wmentioning

confidence: 97%

“…The state was the first in Brazil to report AHR in small ruminants, involving albendazole (SANTOS & GONÇALVES, 1967) and ivermectin (ECHEVARRIA & TRINDADE, 1989), both in sheep. The latter drug also showed effectiveness on sheep farms in the 90s, according to Echevarria et al (1996) and Farias et al (1997).…”

Section: Southern Regionmentioning

confidence: 99%

“…According to Molento (2009), the use of antiparasitic drugs in farm animals over the years offers benefits; however, the continuous and inappropriate use of these drugs has resulted in the loss of effectiveness of many active ingredients. Macrocyclic lactones were launched on the market in the 1980s (CHABALA et al, 1980), but just a few years later, there were reports of the loss their efficiency in Brazil (ECHEVARRIA & TRINDADE, 1989). Recently, two new classes of anthelmintics were launched, an amino-acetonitrile derivative, monepantel (KAMINSKY et al, 2008), and derquantel, which was marketed in association with abamectin (LITTLE et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil

Salgado

Santos

2016

Rev. Bras. Parasitol. Vet.

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Frequent and inappropriate use of all classes of antiparasitic drugs in small ruminants has led to failures in their effectiveness, culminating in a global problem of anthelmintic resistance. Brazil stands out as one of the world's leaders in publications about anthelmintic resistance, and for having the most numerous reports of this resistance in small ruminants in the Americas. These studies have involved mainly the fecal egg count reduction test (FECRT) and its correlation with field management practices. In vivo effectiveness testing is conducted in areas where livestock is of greater economic significance, e.g., in the South (sheep) and Northeast (goats), or is important for research and economic centers, such as the Southeast (sheep). The most widely studied species is sheep, for which the widest range of drugs is also evaluated. Despite significant advances achieved in molecular research, laboratory analyses should include knowledge about the reality in the field so that they can become feasible for the producer. Moreover, molecular studies can be underpinned by the analysis of field studies, such as the maintenance of antiparasitic effectiveness over time and the mechanisms involved in this process.Keywords: Small ruminants, anthelmintic resistance, sheep, goat, gastrointestinal nematodes. ResumoO uso frequente e inapropriado de todas as classes de antiparasitários em pequenos ruminantes levou a falhas de eficácia, culminando na problemática global de resistência anti-helmíntica. O Brasil destaca-se como sendo um dos pioneiros nas publicações com resistência anti-helmíntica no mundo e por ter o maior número de relatos em pequenos ruminantes na América. Essas pesquisas envolvem principalmente o teste da redução da contagem de ovos nas fezes (TRCOF) e sua correlação com as práticas de manejo utilizadas no campo. Os estudos de testes de eficácia in vivo localizam-se em áreas onde há maior importância dos rebanhos como nas Regiões Sul (ovinos) e Nordeste (caprinos), ou com importância em polos de pesquisa e econômicos, como a região Sudeste (ovinos). Ovina é a espécie mais estudada e com maior gama de drogas avaliadas. Mesmo com grande avanço em pesquisas moleculares, as análises laboratoriais devem envolver o conhecimento da realidade do campo para que possam se tornar viáveis ao produtor. Além disso, a análise dos estudos de campo pode nortear estudos moleculares como, por exemplo, a manutenção da eficácia das drogas ao longo dos anos e os mecanismos envolvidos em tal processo.

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Alternative Methods of Controlling Parasites in Small Ruminants

Godfrey¹,

Dodson²

2006

Alternative Health Practices for Livestock

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Anthelmintic resistance by Haemonchus contortus to ivermectin in Brazil: a preliminary report

Cited by 83 publications

References 0 publications

Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do Sertão Paraibano

Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do Sertão Paraibano

Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil

Alternative Methods of Controlling Parasites in Small Ruminants

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