Anthelmintic resistance in goats in peninsular Malaysia

Dorny, Pierre; Claerebout, Edwin; Vercruysse, Jozef; Sani, Rehana Abdullah; Abu, Jalila

doi:10.1016/0304-4017(94)90073-6

Cited by 60 publications

(38 citation statements)

References 29 publications

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“…The reduction in the anthelmintic treatment will be feasible by keeping in mind the local epidemiology of trichostrongylosis and if some additional pasture management strategies are also developed (Coles and Roush 1992). Egg hatch assay was used to confirm the results of FECRT, which indicated development of resistance in gastrointestinal nematodes against OXF on all farms, in contrast to Martin et al (1989) and Dorny et al (1994).…”

Section: Discussionmentioning

confidence: 95%

Oxfendazole Resistance in Gastrointestinal Nematodes of Beetal Goats at Livestock Farms of Punjab (Pakistan)

2007

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Saeed M., Z. Iqbal, A. Jabbar: Oxfendazole Resistance in Gastrointestinal Nematodes of Beetal Goats at Livestock Farms of Punjab (Pakistan). Acta Vet Brno 2007, 76: 79-85. This study was carried out to screen goat farms for anthelmintic resistance (AR) against oxfendazole (OXF) and to determine contributory factors for its development.For this purpose, Beetal goat farms (n = 18) were randomly selected, with natural mixed gastrointestinal nematodosis infection. In vivo (faecal egg count reduction test) and in vitro (egg hatch assay) tests were used to ascertain the presence of AR while a scorecard was used to determine the role of possible contributory factors for oxfendazole resistance. For in vivo test, the experimental animals were divided into two groups of 10 animals each; one group received OXF treatment, while the other served as control. Pre-and post-treatment coproculture was performed to identify the species and genera of nematodes. Egg hatch assay (EHA) was used to confirm the results of FECRT.Fecal egg count reduction test (FECRT) revealed the development of resistance on six farms and post-treatment larval cultures indicated Haemonchus contortus, Trichostrongylus colubriformis, Cooperia curticei, Teladorsagia circumcincta and Oesophagostomum spp. as dominant species with resistance. Furthermore, EHA confirmed the results of FECRT. Among the presumptive factors for AR, the highest composite score was for rotation of anthelmintics followed by treatment frequency, dose rate and nature of medication.The scorecard for the development of AR, used in this study, may be helpful for the assessment of contributory factors of AR.

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Section: Discussionmentioning

confidence: 95%

Oxfendazole Resistance in Gastrointestinal Nematodes of Beetal Goats at Livestock Farms of Punjab (Pakistan)

2007

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“…There is also strong evidence that resistance develops more rapidly in regions where animals are dewormed regularly. Serious problems with AR in Haemonchus contortus were reported in some humid tropical areas where 10 to 15 treatments per year were used to control this parasite in small ruminants (42).…”

Section: Contributing Factors For the Development Of Resistancementioning

confidence: 99%

“…This in vitro test has the advantage of requiring only one fecal sample. However, several authors have reported poor correlations between the results of the FECRT and the egg hatch test for helminths of livestock (14,42).…”

Section: Detection Of Drug Resistancementioning

confidence: 99%

Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock

Geerts

Gryseels

2000

Clinical Microbiology Reviews

231

130

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“…The main factor evoked to select for resistance concerns treatment frequency and, "a large number of anthelmintic treatments with the same anthelmintic family for years" is taken as the key factor for selecting for resistance [91]. This statement is supported by surveys realised on a regional scale, in New Zealand [59,83]; in Malaysia [33]; in South Africa [95]; in the United Kingdom [53,75]; in Australia [36,72]. The "same" repeated anthelmintic treatment is a major cause, in experimental and oversimplified conditions (three-month-old lambs, synchronous infestation with only one to three gastro-intestinal nematode species...) of positive correlation between intensity of resistance and treatment frequency [5,66,71].…”

Section: Introductionmentioning

confidence: 99%

Sheep and goat nematode resistance to anthelmintics: pro and cons among breeding management factors

et al. 2002

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-Although the molecular bases of resistance to anthelmintic families have been intensively studied, the contributing factors for the development of anthelmintic resistance are less well known. Clear recommendations must be given to farmers in order to delay the onset of anthelmintic resistance. Until now, the main advice has concerned the reduction of treatment frequency in order to slow down the spread of resistance. Anthelmintic resistance development depends mostly on an efficient selection pressure. This means that a high treatment frequency is neither necessary nor sufficient to select for resistance. The contribution of resistant worms, which have survived an anthelmintic treatment, to the subsequent generation is the key factor that controls resistance spread. This point is illustrated by five surveys conducted on sheep and goat farms from France and Morocco. In the 52 farms studied, less than three anthelmintic treatments were given each year. Three characteristics of breeding management can be identified in the build up of anthelmintic resistance: (1) the introduction of resistant worms through the purchase of sheep/goats or the use of common pastures, grazed by several herds/flocks, (2) under-dosing of hosts and the repeated use of one class of drugs, (3) the size of the population in refugia (infective larvae on pastures) at the time of the treatment. The role played by these breeding management factors in selecting for resistance is discussed. The most efficient way to limit the increase of anthelmintic resistance remains the reduction of the selection pressure by drugs, and optimal timing to maximise their efficacy. Bien que les bases moléculaires de la résistance aux différentes familles d'anthelminthiques aient été très étudiées, les facteurs permettant le développement de la résistance anthelminthique sont moins bien connus. Des recommandations claires sont nécessaires aux éleveurs si l'on souhaite retarder l'apparition de la résistance aux anthelminthiques. La principale recommandation a consisté à réduire la fréquence des traitements de façon à ralentir le développement de la résis-tance. Le développement de la résistance anthelminthique dépend essentiellement d'une pression de sélection efficace. Cela signifie qu'une forte fréquence de traitements n'est ni nécessaire ni suffisante pour sélectionner la résistance. La contribution des vers résistants, qui ont survécu au traitement anthelminthique, à la génération suivante est le facteur clé qui contrôle le développement de la résis-tance. Ce point est illustré par cinq enquêtes réalisées dans des élevages ovins et caprins de France et du Maroc. Dans les 52 élevages étudiés, moins de trois traitements anthelminthiques par an étaient réalisés. Trois conditions d'élevage ont pu être mises en évidence comme étant impliquées dans le dé-veloppement de la résistance anthelminthique :

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Anthelmintic resistance in goats in peninsular Malaysia

Cited by 60 publications

References 29 publications

Oxfendazole Resistance in Gastrointestinal Nematodes of Beetal Goats at Livestock Farms of Punjab (Pakistan)

Oxfendazole Resistance in Gastrointestinal Nematodes of Beetal Goats at Livestock Farms of Punjab (Pakistan)

Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock

Sheep and goat nematode resistance to anthelmintics: pro and cons among breeding management factors

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