Anthelmintic screening of Zimbabwean plants traditionally used against schistosomiasis

Mølgaard, Per; Nielsen, Susanne B; Rasmussen, Dorthe E; Drummond, R.B.; Makaza, N.; Andreassen, J.

doi:10.1016/s0378-8741(00)00377-9

Cited by 123 publications

(90 citation statements)

References 12 publications

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“…Molgaard et al (2001) screened extracts of 23 plant species from Zimbabwe and found that the stem and root extracts from Abrus precatorius (Fabaceae) and stem bark extracts from Elephantorrhiza goetzei (Mimosaceae) have a good activity against schistosomules. Sparg et al (2000) screened 21 species from South Africa against the schistosomula of S. haematobium, where Berkheya speciosa (Asteraceae), Euclea natalensis (Ebenaceae), and Trichilia emetica (Meliaceae) were found lethal.…”

Section: Resultsmentioning

confidence: 99%

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Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Yousif

Hifnawy

Soliman

et al. 2007

Pharmaceutical Biology

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In vitro bioassay screening of 346 methanol extracts originated from 281 native and cultivated plant species growing in Egypt, and related to 81 families, was carried out for schistosomicidal activity. The extracts were bioassayed at 100 mg=mL on viable Schistosoma mansoni mature worms in culture medium. Viability of worms was examined after exposure for 24 h, and mortality determined. Negative (DMSO) and positive (praziquantel) controls were used. Of the tested plant extracts, 72 were found to possess reproducible in vitro antischistosomal activity. These active extracts were further subjected to determination of their LC 50

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Section: Resultsmentioning

confidence: 99%

“…Whereas herbal medicine has produced some very effective treatments for malaria, for example, quinine and recently artemisinin (Frederich et al, 2002), few attempts have been made to screen plants against schistosomiasis (Sparg et al, 2000;Molgaard et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Yousif

Hifnawy

Soliman

et al. 2007

Pharmaceutical Biology

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“…Traditional medicinal plants were applied by some authors for the treatment of schistosomiasis (Ndamba et al, 1994, Sparg et al, 2000, Molgaard et al, 2001. One of these compounds is curcumin.…”

Section: Introduction:-mentioning

confidence: 99%

Antiparasitic and physiological evaluation of Curcuma longa extract and/or PZQ on Schistosoma mansoni infected mice.

Aboueldahab¹,

Elhussieny.²

2016

IJAR

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Praziquantel (PZQ) is the drug of choice against schistosomiasis. However, PZQ was found not fully effective. A new trend from natural plant sources was used to compete schistosomiasis. In the present study, the antischistosomal activities of Curcumin extract and /or PZQ were evaluated. Parasitological and histopathological examination of liver has been explored. Moreover, Surface topography of the recovered worms was inspected by SEM. On the other hand, the total protein and DNA fragmentation percentage were estimated in infected and infected treated mice as compared to control group. Treatment of infected CD1 mice with curcumin extract alone didn't show any detectable changes in the parasitological or histological parameters. The infected mice treated with PZQ only, showed a significant decrease in the total worm burden, egg load (52%), with increase in degenerated eggs (58%) in the oogram pattern.However, treating infected CD1 mice with combined therapy (curcumin extract + PZQ) showed extremely significant reduction in female and male worm count (93% & 84%) respectively. Liver tissue egg load decreased by 88%, intestinal egg load decreased by 97%. Combined therapy decreased granuloma count and diameter with significant increase in degenerated egg in the oogram count. Moreover, the studied biomarkers, related to liver function and DNA damage were significantly improved in infected mice treated with curcumin combined with PZQ as compared to either drug alone. . In conclusion, curcumin extract in combination with PZQ has a synergetic effect and could be more promising in controlling schistosomiasis.Copy Right, IJAR, 2016,. All rights reserved.

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“…1 H-NMR (300 and 500 MHZ, DMSO-d 6 ) and 13 C-NMR (75 and 125 MHZ, DMSO-d 6 ) spectra were recorded on a varian Mecauy 300 or 500 JEOL GX-Spectrometer. The chemical shifts in δ were referenced to using TMS as internal standard.…”

Section: Generalmentioning

confidence: 99%

“…Moreover, the reliance on one antischistosomal drug is alarming, therefore the scientific community has called for research and development of novel and inexpensive drugs against schistosomiasis (3,4) . In this respect, compounds from natural sources mainly plants, which continue to be a major source of biologically active metabolites may lead to the development of new drugs (5)(6)(7) . Plants are still a large source of natural antioxidants that might serve for the development of novel drugs (8) .…”

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confidence: 99%

Chemical Constituents, Antischistosomal and Antioxidant Activities of the Methanolic Extract of Azadirachta indica

2011

Egypt. J. Chem.

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HE PRESENT study was performed to evaluate the in vitro …….. schistosomicidal effect of 70% methanolic extract of the leaves of Azadirachta indica and its derived ethyl acetate and n-butanol fractions against adult Schistosoma mansoni worms. Also, antioxidant properties of these extracts were determined. Owing to the high antischistosomal and antioxidant activities of EtOAc and n-BuOH fractions, they were subjected to chromatographic isolation using different chromatographic techniques. Two flavonoid compounds; (1,2) were isolated from EtOAc fraction whereas one flavonoid; (3) quercetin-3-O-α-L-rhamnopyranoside and two bidesmosidic saponins; (4,5) were isolated from the butanolic fraction. Their structures were established using spectroscopic methods. Compounds 1-3 showed high antioxidant activity whereas compounds 4 and 5 were inactive. It is the first time that antischistosomal activity of A.indica and isolation of compounds 2-5 from this plant were carried out.

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Anthelmintic screening of Zimbabwean plants traditionally used against schistosomiasis

Cited by 123 publications

References 12 publications

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Large-scalein Vitro. Screening of Egyptian Native and Cultivated Plants for Schistosomicidal Activity

Antiparasitic and physiological evaluation of Curcuma longa extract and/or PZQ on Schistosoma mansoni infected mice.

Chemical Constituents, Antischistosomal and Antioxidant Activities of the Methanolic Extract of Azadirachta indica

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