Anthocyanin extract of Lannea microcarpa fruits stall oxidative rout associated with aflatoxin B1 hepatocarcinogenesis

Ajiboye, Taofeek O.; Raji, Hikmat O; Muritala, H.F.; Ojewuyi, Oluwayemisi B; Yakubu, Musa Toyin

doi:10.1016/j.fbio.2013.09.002

Cited by 23 publications

(14 citation statements)

References 45 publications

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“…This was similar to reference antioxidant (vitamin C) used in this study. The capability of the two oils to reduce K 3 Fe(CN) 6 significantly (p < 0.005) shows its effectiveness to halt the oxidation of cellular macromolecules by oxidizing molecules that could arise from the metabolism of either drugs or toxins (Ajiboye et al 2013). Also, the reducing effect of the oils was similar to that produced by vitamin C (Figure 2), but the greatest activity was observed in fresh leaf oil.…”

Section: Resultsmentioning

confidence: 55%

Identification and comparison of the volatile constituents of fresh and dried leaves ofSpondias mombinfound in North-central Nigeria:in vitroevaluation of their cytotoxic and antioxidant activities

Oladimeji

Aliyu

Ogundajo

et al. 2016

Pharmaceutical Biology

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Context:Various studies have shown that the leaf extracts of Spondias mombin Linn (Anacardiaceae) possess pharmacological properties such as antioxidant and antiviral effects. However, no biological activity from its essential oil has been reported in literature. Objective: To analyse the chemical constituents, cytotoxic activity and antioxidant capability of the essential oils from fresh and dried leaves of S. mombin. Materials and methods: Hydrodistillation using Clevenger-type apparatus was employed to obtain the essential oil. Oil analysis was performed using an HP 6890 Gas Chromatograph coupled with an HP 5973 Mass Selective Detector. The cytotoxicity bioassay was carried out using the brine shrimp lethality test (10,000-0.01 lg/mL). Additionally, the reactive oxygen species scavenging potential of the two S. mombin oils (1000-200 lg/mL) were investigated using a hydroxyl radical scavenging and ferric iron reducing system. Results: Chemical analysis of essential oils from S. mombin revealed the presence of 41 compounds, with predominance of monoterpenoids, sesquiterpenoids and non-terpenoids derivatives. In both fractions, the principal component was b-caryophellene (27.9-30.9%), followed by c-cadinene (9.7-12.3%). There was an increase in the oxygenated monoterpenoid contents and a concomitant decrease in the amounts of sesquiterpenoids hydrocarbons observed on drying the leaves. The oil obtained from the fresh leaves was more active than that obtained from dried leaves, with LC 50 values (from the brine shrimp lethality assay) of 0.01 and 4.78 lg/mL, respectively. The two oils (from fresh and dried leaves) at 1.0 mg/mL scavenged hydroxyl radical by 83% and 99.8%, respectively. Moreover, they reduced ferric ion significantly and compared favourably with vitamin C. Conclusions: Essential oil derived from the leaves of S. mombin could hold promise for future application in the treatment of cancer-related diseases. ARTICLE HISTORY

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Section: Resultsmentioning

confidence: 55%

Identification and comparison of the volatile constituents of fresh and dried leaves ofSpondias mombinfound in North-central Nigeria:in vitroevaluation of their cytotoxic and antioxidant activities

Oladimeji

Aliyu

Ogundajo

et al. 2016

Pharmaceutical Biology

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“…and eventually cell death (Ajiboye et al, 2010). Similar reduction in activity of SOD, CAT, GSH-Px and GSH-Red (ROS detoxifying enzymes) were reported to be due to excessive generation of ROS during AFB 1 hepatocarcinogenesis (Ramakrishnan et al, 2006;Yadav and Bhatnagar, 2007;Sivaramakrishnan et al, 2008;Ajiboye et al, 2013). Thus, significant attenuation of AFB 1 -mediated reduction in specific activities of ROS detoxifying enzymes by P. biglobosa pulp extract indicates a protective activity.…”

Section: Tablementioning

confidence: 72%

“…AFB 1 has been reported to induce lipid peroxidation both in vitro and in vivo models of AFB 1 -induced hepatotoxicity (Shen et al, 1994;Towner et al, 2003;Theumer et al, 2010;Ravinayagam et al, 2012;Ajiboye et al, 2013). Thus, the significant increase in the levels of lipid peroxidation products (conjugated dienes, lipid hydroperoxides and malondialdehydes) shows indiscriminate oxidative assaults on cellular lipids.…”

Section: Lipid Peroxidationmentioning

confidence: 95%

Phenolic extract of Parkia biglobosa fruit pulp stalls aflatoxin B1 – mediated oxidative rout in the liver of male rats

Ajiboye

Adeleye

Salau

et al. 2014

Revista Brasileira de Farmacognosia

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Oxidative stress DNA fragmentation lipid peroxidation A B S T R A C TThe effect of phenolic extract of Parkia biglobosa (Jacq.) R. Br. ex G. Don, Fabaceae, pulp on aflatoxin B 1 induced oxidative imbalance in rat liver was evaluated. Thirty-five male rats were randomized into seven groups of five animals each. Rats in group A served as control and received vehicle for drug administration (0.5% DMSO) once daily at 24 h intervals for six weeks. Rats in groups B, D, E, F and G, received aflatoxin B 1 (167 μg/kg body weight) in 0.5% DMSO for three weeks, starting from the third week of the experimental period. Rats in Group C received 400 mg/kg bodyweight of the extract for six weeks, while groups D, E and F rats were treated with 100, 200 and 400 mg/kg bodyweight of the extract for six weeks respectively. Group G rats received 100 mg/kg body weight of vitamin C. Aflatoxin B 1 -mediated decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase were significantly attenuated. Aflatoxin B 1 mediated the elevation in malondialdehyde, conjugated dienes, lipid hydroperoxides, protein carbonyl, and significantly lowered DNA fragmentation percentage.Overall, the phenolic extract of P. biglobosa pulp stalls aflatoxin B 1 -mediated oxidative rout by enhancing antioxidant enzyme activities leading to decreased lipid peroxidation, protein oxidation and DNA fragmentation.

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“…Phytochemical constituents such as steroids, glycosides, tannins, saponins, triterpenoids, alkaloids, and flavonoids were present in the extract of the stem bark of Lannea microcarpa which is in consonant with the earlier phytochemical screening conducted. 14,16,[18][19][20] In this study, dextran sulphate injected in the rats induces anaphylactic reaction characterized by extravasation and oedema formation as a result of histamine and serotonin release from the mast cells. 25 Dextran is known to be a potent osmotic agent which causes significant increase in vascular permeability and blood flow to the inflammatory site.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12][13][14][15][16][17][18] Quantitative determination of phytochemical composition of the plant has been reported and this revealed the presence of numerous phytochemical constituents. 14,[18][19][20][21] Due to these numerous positive reports on this plant, it is therefore imperative that we carry out a scientific research on the antiinflammatory effect of aqueous extract of this time tested plant to provide a valid scientific data to support its traditional uses.…”

Section: Introductionmentioning

confidence: 99%

Aqueous extract of Lannea microcarpa attenuates dextran sulphate-induced paw oedema and xylene-induced ear oedema in rodents

Antwi-Adjei

Owusu

Ameade

2017

Int J Basic Clin Pharmacol

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Background: Lannea microcarpa Engl. and K. Krause (Family Anacardiaceae), a tropical tree is used traditionally used in Africa for both medicinal and non-medicinal purposes. Folkoric uses of the plant include wound healing, conjunctivitis, stomatitis and gingivitis among others. Inflammatory reactions are involved in several diseases which this plant is traditionally used to manage. This study was therefore aimed at investigating the antiinflammatory effects of the aqueous extract of Lannea microcapa.Methods: Oedema was induced in the right hind paws of Sprague Dawley rats (200-250g, 12 weeks old, n=5) using dextran sulphate solution whiles ear oedema was induced in ICR mice (25-30g, 6 weeks old, n=5) using xylene solutions. Aqueous extracts of ALM (30, 100 and 300mg kg-1) were administered in a set of rats and mice for both prophylactic and therapeutic studies. In the dextran sulphate-induced paw oedema, rats (200-250g) were treated orally with ALM (30, 100 and 300 mg kg-1) for both prophylactic and therapeutic studies. The paw thickness of the rats was measured before and after dextran sulphate injection at an hourly interval for 5 h. For xylene-induced ear oedema, ICR mice (25-30g) were given the same doses of the ALM and the ear weight of mice were measured after 2 h.Results: In the dextran sulphate-induced paw oedema, the ALM reduced the mean maximal paw oedema significantly (P ≤0.05) to 36.392±9.207% and 26.050±3.396% at 100 and 300 mg kg-1 (prophylaxis) and 32.192±5.670%, 31.398±6.921% and 31.593±5.841% at 30, 100 and 300 mg kg-1 (therapeutic) in dose dependent manner when compared to the control respectively. Similarly, the ALM dose dependently showed a significant (P ≤0.05) reduction of percentage mean oedema in xylene-induced ear oedema by 43.56%, 59.63% and 68.07% at 30, 100 and 300 mg kg-1 when compared to the control respectively.Conclusions: Aqueous extract of Lannea microcapa (30 -300 mg kg-1) caused significant reduction of oedema in both dextran sulphate-induced paw oedema and xylene-induced ear oedema.

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Anthocyanin extract of Lannea microcarpa fruits stall oxidative rout associated with aflatoxin B1 hepatocarcinogenesis

Cited by 23 publications

References 45 publications

Identification and comparison of the volatile constituents of fresh and dried leaves ofSpondias mombinfound in North-central Nigeria:in vitroevaluation of their cytotoxic and antioxidant activities

Identification and comparison of the volatile constituents of fresh and dried leaves ofSpondias mombinfound in North-central Nigeria:in vitroevaluation of their cytotoxic and antioxidant activities

Phenolic extract of Parkia biglobosa fruit pulp stalls aflatoxin B1 – mediated oxidative rout in the liver of male rats

Aqueous extract of Lannea microcarpa attenuates dextran sulphate-induced paw oedema and xylene-induced ear oedema in rodents

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