Anthocyanin from purple sweet potato attenuates lead-induced reproductive toxicity mediated by JNK signaling pathway in male mice

Zhou, Li; Zhang, Chaoqin; Yu, Qiang; Huang, Min; Ren, Xiangmei; Li, Yuanhong; Shao, Jingjing; Xu, Li‐Chun

doi:10.1016/j.ecoenv.2021.112683

Cited by 18 publications

(8 citation statements)

References 44 publications

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“…10 JNKs are phosphorylated and activated in neurons in response to various stimuli, wherein c-Jun, a well-defined downstream target of JNK, plays an obligatory role in the death process. 11 Recently, JNK/c-Jun-dependent neuronal apoptosis has been implicated in TMT-induced neurotoxicity. 12,13 Besides, neuroinflammation has been proved to be a major component contributing to TMT-induced neurotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of chlorogenic acid on trimethyltin chloride-induced neurobehavioral dysfunctions in mice relying on the gut microbiota

et al. 2022

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Protective effects of chlorogenic acid on trimethyltin chloride-induced neurobehavioral dysfunctions in mice relying on the gut microbiota

et al. 2022

Food Funct.

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“…The sperm deformity rate was assessed through Giemsa staining (Zhou et al, 2021 ). The sperm plasma membrane integrity rate was evaluated using the hypo-osmotic swelling test method (Zakošek et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

“…After making an incision, a 2 × 2 cm section of testicular tissue from the same region was obtained and subsequently transformed into a tissue block measuring approximately 10 mm × 10 mm × 5 mm. These sections were stained, dried, sealed with a neutral gum sealing agent, and microscopically examined (Zhou et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Study on the correlation of supplementation with L-citrulline on the gastrointestinal flora and semen antifreeze performance of ram

Fan,

Aihemaiti,

Fan

et al. 2024

Front. Microbiol.

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IntroductionCryopreservation of semen can give full play to the reproductive advantages of male animals. However, in actual production, due to the poor frost resistance of sheep semen and the low conception rate, the promotion of sheep frozen semen is greatly hindered. Therefore, it is urgent to improve the frost resistance of semen to improve the quality of frozen semen. At present, most studies on improving the quality of frozen semen are based on the improvement of semen dilutions, and few studies on improving the freezing resistance of ram semen by feeding functional amino acids.MethodsTherefore, 24 Turpan black rams were divided into high antifreeze group (HF) and a low antifreeze group (LF) Each of these groups was further randomly divided into control and experimental subgroups. The control subgroup was fed a basal diet, while the experimental subgroup received an additional 12 g/d of L-Cit supplementation based on the control group for a duration of 90 days.ResultsThe results showed that Following L-Cit supplementation, the experimental group demonstrated significantly elevated sperm density and VSL (Velocity of straight line), T-AOC, GSH-Px, and NO levels in fresh semen compared to the control group (P < 0.01). After thawing, the experimental group exhibited significantly higher levels of T-AOC, GSH-Px, and NO compared to the control group (P < 0.01). Additionally, the HFT group, after thawing frozen semen, displayed significantly higher HK1 protein expression compared to the control group. The number of spermatogonia, spermatocytes, and sperm cells in the HFT group was significantly higher than that in the HFC group. Moreover, 16S rRNA sequence analysis showed that Candidatus_Saccharimonas, Staphylococcus, Weissella, succinivbrionaceae_UcG_002, and Quinella were significantly enriched in the rumen of the HFT group, while Ureaplasma was significantly enriched in the HFC group. In the duodenum, Clostridiales_bacterium_Firm_14, Butyrivibrio, and Prevotellaceae_NK3831_group were significantly enriched in the HFT group, whereas Desulfovibrio and Quinella were significantly enriched in the HFC group.DiscussionUnder the conditions employed in this study, L-Cit supplementation was found to enhance the intestinal flora composition in rams, thereby improving semen quality, enhancing the antifreeze performance of semen, and promoting the development of testicular spermatogenic cells.

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“…The findings of the study demonstrated that the testicular damage induced by Pb was alleviated, the number and motility of sperm were increased, and the abnormal rate of sperm was decreased in the presence of anthocyanin from purple sweet potato. Furthermore, the c‐Jun N‐terminal kinase has been found to exhibit a strong correlation with the current protective effects attributed to alleviating oxidative stress (Zhou et al., 2021). In addition, it has been observed that the consumption of foods that are abundant in anthocyanins can effectively mitigate the adverse effects of Pb‐induced toxicity, including histopathological alterations in renal tissue (Aksu et al., 2017), and a decrease in mineral absorption (Li et al., 2020a).…”

Section: Influence Of Anthocyanins On Food Contaminants From the Natu...mentioning

confidence: 99%

Mechanism of action of anthocyanin on the detoxification of foodborne contaminants—A review of recent literature

Jiang,

Li,

Zhang

et al. 2023

Comp Rev Food Sci Food Safe

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Foodborne contaminants refer to substances that are present in food and threaten food safety. Due to the progress in detection technology and the rising concerns regarding public health, there has been a surge in research focusing on the dangers posed by foodborne contaminants. These studies aim to explore and implement strategies that are both safe and efficient in mitigating the associated risks. Anthocyanins, a class of flavonoids, are abundantly present in various plant species, such as blueberries, grapes, purple sweet potatoes, cherries, mulberries, and others. Numerous epidemiological and nutritional intervention studies have provided evidence indicating that the consumption of anthocyanins through dietary intake offers a range of protective effects against the detrimental impact of foodborne contaminants. The present study aims to differentiate between two distinct subclasses of foodborne contaminants: those that are generated during the processing of food and those that originate from the surrounding environment. Furthermore, the impact of anthocyanins on foodborne contaminants was also summarized based on a review of articles published within the last 10 years. However, further investigation is warranted regarding the mechanism by which anthocyanins target foodborne contaminants, as well as the potential impact of individual variations in response. Additionally, it is important to note that there is currently a dearth of clinical research examining the efficacy of anthocyanins as an intervention for mitigating the effects of foodborne pollutants. Thus, by exploring the detoxification effect and mechanism of anthocyanins on foodborne pollutants, this review thereby provides evidence, supporting the utilization of anthocyanin‐rich diets as a means to mitigate the detrimental effects of foodborne contaminants.

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Anthocyanin from purple sweet potato attenuates lead-induced reproductive toxicity mediated by JNK signaling pathway in male mice

Cited by 18 publications

References 44 publications

Protective effects of chlorogenic acid on trimethyltin chloride-induced neurobehavioral dysfunctions in mice relying on the gut microbiota

Protective effects of chlorogenic acid on trimethyltin chloride-induced neurobehavioral dysfunctions in mice relying on the gut microbiota

Study on the correlation of supplementation with L-citrulline on the gastrointestinal flora and semen antifreeze performance of ram

Mechanism of action of anthocyanin on the detoxification of foodborne contaminants—A review of recent literature

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