Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats

Bishayee, Anupam; Mbimba, Thomas; Thoppil, Roslin J.; Háznagy-Radnai, Erzsébet; Sipos, Péter; Darvesh, Altaf S.; Folkesson, Hans G.; Hohmann, Judit

doi:10.1016/j.jnutbio.2010.09.001

Cited by 122 publications

(65 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Less is known concerning was the chemopreventive effect of anthocyanins on diethylnitrosamine and phenobarbital induced hepatocarcinogenesis in rats. Bishayee et al reported that an anthocyanins richextract from black currant had chemopreventive effects against diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis via inhibition of abnormal cell proliferation and induction of apoptosis (Bishayee et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Cleistocalyx nervosum Extract Ameliorates Chemical-Induced Oxidative Stress in Early Stages of Rat Hepatocarcinogenesis

Taya

Punvittayagul²,

Inboot³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Purpose: To study the effect of Cleistocalyx nervosum extract (CE) on diethylnitrosamine (DEN) and phenobarbital (PB) induced oxidative stress in early stages of rat hepatocarcinogenesis. Materials and Methods: Male Wistar rats were divided into 4 groups, with Group 1 as a negative control and Group 2 was a positive control receiving DEN injections once a week and PB in drinking water for 6 weeks. Two weeks before DEN initiation and PB treatment, Groups 3 and 4, were fed with 500 and 1000 mg/kg of CEs, respectively, for 8 weeks. Results: A number of GST-P-positive foci, preneoplastic lesions, in the liver were markedly increased in carcinogen administered rats, but was comparatively decreased in rats treated with 1000 mg/kg of CE. The CE reduced malondialdehyde in serum and in the livers of rats treated with DEN and PB. Moreover, CE significantly increased the activities of glutathione peroxidase and catalase in rat liver. Conclusions: CE appeared to exert its chemopreventive effects by modulating antioxidant status during DEN and PB induced early stages of hepatocarcinogenesis in rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Cleistocalyx nervosum Extract Ameliorates Chemical-Induced Oxidative Stress in Early Stages of Rat Hepatocarcinogenesis

Taya

Punvittayagul²,

Inboot³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Aliment., 16(4), 361-370. http://dx.doi.org/10.17306/J. AFS.2017.0530 www.food.actapol.net/ Bishayee et al (2010) demonstrated that cyanidin--3-O-rutinoside ( Fig. 1), an anthocyanin present in the extract of black gooseberry, could inhibit the growth of liver cancer HepG2 cells.…”

Section: Antioxidants From Berry Fruitsmentioning

confidence: 99%

Natural antioxidant extracts as food preservatives

Santos-Sánchez

Salas-Coronado

Valadez-Blanco

et al. 2017

Acta Sci Pol Technol Aliment

View full text Add to dashboard Cite

The food industry is becoming more specialized and processing methods are continuously being developed to meet consumer needs. Consumers demand products that are safe and preferably free of synthetic additives. These additives are associated with health effects, in most cases without reasonable justification. Consequently, consumers are looking for clearly labelled products that guarantee the absence of synthetic additives. This has led to the need to search for natural additives, which the food industry claims arenatural antioxidant preservatives. The sources of natural antioxidants can be extremely varied, because practically all plants contain antioxidants that allow them to protect themselves from solar radiation and pests, as well as to regulate the production of chemical energy. However, the best alternatives for the food industry are fruits and spices, because they are already foods themselves. This article will describe fruits and spices considered as important sources of phenolic antioxidants. The main medicinal properties are related to phenolic compounds and their uses as additives, depending on their chemical structure. Keywords

show abstract

“…They have several biological activities, including antioxidant, anti-inflammatory, antitumor, neuroprotective, anti-diabetic and cancer chemopreventive agents [57][58][59][60][61][62][63][64][65][66][67][68] . Additionally, they are widely used as colorants in food industry 69 .…”

Section: Anthocyaninsmentioning

confidence: 99%

Phenolics and Ascorbic Acid Related to Antioxidant Activity of MaoFruit Juice and Their Thermal Stability Study (Review Article)

Sripakdee¹,

Mahachai²,

Chanthai³

2017

Orient. J. Chem

View full text Add to dashboard Cite

Antioxidant and/or anti-aging activities are always lined with people's minds as major potential benefits concerning human health in the recent commercial features for an economic world of foodstuffs and medical uses. Total phenolics including flavonoids and anthocyanins, and ascorbic acid in the Mao juices are closely related to their antioxidant activity. Numerous research approaches on these functional foods, in particular the colored fruits and vegetables have been investigated. Method validation and determination of the potential compounds have been increasingly developed with highly sensitive and selective procedures and applications including thermal stability of the Mao juice. Their antioxidant activities obtained from different assays related to the contents of both phenolics and ascorbic acid in the anthocyanins-rich Mao juices in Thailand are reported and discussed.

show abstract

Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats

Cited by 122 publications

References 72 publications

Cleistocalyx nervosum Extract Ameliorates Chemical-Induced Oxidative Stress in Early Stages of Rat Hepatocarcinogenesis

Cleistocalyx nervosum Extract Ameliorates Chemical-Induced Oxidative Stress in Early Stages of Rat Hepatocarcinogenesis

Natural antioxidant extracts as food preservatives

Phenolics and Ascorbic Acid Related to Antioxidant Activity of MaoFruit Juice and Their Thermal Stability Study (Review Article)

Contact Info

Product

Resources

About