Anthocyanin-rich Buni-berry (Antidesma bunius) Extract Increases Paraoxonase 1 Gene Expression in BALB/c Mice Fed with a High-fat Diet

Abstract

All the mice were caged in groups of six under environmentally controlled room with 12 h light/dark cycle and provide standard rodent diet and water ad libitum until further 30 weeks of age. The 30 weeks old mice were then randomly allocated into the four experiment groups that matched for body weight (Table 3). Diets Standard diet (control diet) D12102 and high fat diet Clinton/Cybulsky D12109 used, were purchased from Research Diet Inc. USA. The control diet D12102 contained 10% calory from fat. The high fat diet contained 40% calory from fat mainly from cocoa butter with 1.25% cholesterol (w/w)

Antidesma bunius (L.) Spreng. (Foodstuffs and Its Bioactivity)

“…The A. bunius fruit has anti-obesity potential because it has an effect on lipase enzyme activity (Krongyut and Sutthanut, 2019). The mice fed a high-fat diet then treated with A. bunius fruit extract orally 300 mg/kgBW/day for 12 weeks increased PON1 mRNA expression in BALB/c mice fed a high-fat diet comparable to the group of mice given simvastatin (Tawali et al, 2019). Ethanol extract A. bunius showed adipocyte adipogenesis inhibitory effect whose activity was directly proportional to concentration (Krongyut and Sutthanut, 2019).…”

Chemical constituents of Antidesma bunius aerial parts and the anti-AGEs activity of selected compounds

“…Mauldina and colleagues (2017) published a study on the bioactivity-guided isolation of natural products from A. bunius stem bark, which identified friedelin, β-sitosterol, and betulinic acid as potent α-glucosidase inhibitors (Mauldina et al, 2017). Other studies focused on pharmacological properties of A. bunius berries, indicating inhibition of the adipogenesis process and differentiation of adipocytes (Krongyut and Sutthanut, 2019), stimulation of fat metabolism in the liver (Ngamlerst et al, 2019), and a reduced formation of plaques in arteries (Tawali S et al, 2019). Besides, to the best of our knowledge, nothing else is known about the phytochemical composition of A. bunius aerial parts.…”