Anthocyanin-rich plum juice reduces ambulatory blood pressure but not acute cognitive function in younger and older adults: a pilot crossover dose-timing study

Igwe, Ezinne O; Charlton, Karen E; Roodenrys, Steven; Kent, Katherine; Fanning, K.; Netzel, M.

doi:10.1016/j.nutres.2017.08.006

Cited by 46 publications

(28 citation statements)

References 66 publications

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“…The long-lasting effects of AV and TO on heart rate indicate that they may be effective antihypertensive agents or could function as ACE and/or renin inhibitors in hypertensive patients. The results are consistent with a recent report that showed significant heart rate lowering effect after consumption of an anthocyanin-rich beverage by human volunteers over a 24-h test period (Igwe et al, 2017).…”

Section: Effect Of Vegetable Extracts On Map and Hrsupporting

confidence: 93%

Antihypertensive effect of aqueous polyphenol extracts of Amaranthusviridis and Telfairiaoccidentalis leaves in spontaneously hypertensive rats

Olarewaju¹,

Alashi²,

Aluko³

2018

Journal of Food Bioactives

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The antihypertensive effects of aqueous polyphenol-rich extracts of Amaranthusviridis (AV) and Telfairiaoccidentalis (TO) leaves in spontaneously hypertensive rats (SHR) were investigated. The dried vegetable leaves were extracted using 1:20 (leaves:water, w/v) ratio for 4 h at 60 °C. Results showed significantly (P < 0.05) higher polyphenol contents in TO extracts (80–88 mg gallic acid equivalents, GAE/100 mg) when compared with the AV (62–67 mg GAE/100 mg). Caffeic acid, rutin and myricetin were the main polyphenols found in the extracts. The TO extracts had significantly (P < 0.05) higher in vitro inhibition of angiotensin I-converting enzyme (ACE) activity while AV extracts had better renin inhibition. Oral administration (100 mg/kg body weight) to SHR led to significant (P < 0.05) reductions in systolic blood pressure for the AV (−39 mmHg after 8 h)and TO (−24 mmHg after 4 and 8 h).The vegetable extracts also produced significant (P < 0.05) reductions in diastolic blood pressure, mean arterial blood pressure and heart rate when compared to the untreated rats. Thus both the AV and TO leaf extracts have the potential to be used as antihypertensive agents, especially the AV, which produced persistent long-lasting effect over a 24 h period.

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Section: Effect Of Vegetable Extracts On Map and Hrsupporting

confidence: 93%

Antihypertensive effect of aqueous polyphenol extracts of Amaranthusviridis and Telfairiaoccidentalis leaves in spontaneously hypertensive rats

Olarewaju¹,

Alashi²,

Aluko³

2018

Journal of Food Bioactives

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“…The results obtained in the present study showed a significant association between anthocyanin intake in older adults and lower BP. This result is in agreement with current evidence from clinical and epidemiological studies on the effect of dietary anthocyanins on BP in acute settings and over the longer term (7,8,49) . Anthocyanins have also been classified as nutraceuticals with respect to their ability, as part of a food component, to provide health and medical benefits (50) .…”

Section: Discussionsupporting

confidence: 92%

“…Evidence from BP intervention studies has shown that more significant effects are observed in older adults (7,8) and elevated BP as part of metabolic syndrome is common in people aged 50+ years (30) . Therefore, a secondary aim of the present study was to determine whether there was an association between anthocyanin intakes and BP in Australians aged ≥50 years.…”

Section: Introductionmentioning

confidence: 99%

Usual dietary anthocyanin intake, sources and their association with blood pressure in a representative sample of Australian adults

Igwe

Charlton

Probst

2019

J Human Nutrition Diet

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Background Anthocyanins represent an important subgroup of non‐nutritive components of food as evidence continues to build related to their beneficial bioactive effects. Using a recently developed Australian anthocyanin database, the present study aimed to estimate the intake of both total anthocyanins and their subclasses, identify food sources of anthocyanins, and determine associations between anthocyanin intake and measured blood pressure (BP). Methods The present study comprised a secondary analysis of the 2011–12 National Nutrition and Physical Activity component of the Australian Health Survey. Anthocyanin intake was estimated using an Australian anthocyanin database. Usual anthocyanin intake, as estimated from 24‐h diet recall data, was computed using multiple source methods, whereas food sources were determined by calculating contribution of food groups to total anthocyanin intake. Regression analysis, adjusted for covariates (age, gender, body mass index, high BP diagnosis, smoking status and physical activity) assessed the relationship between anthocyanin intake and BP in adults aged ≥50 years. Results Mean anthocyanin intake was 24.17 ± 0.32 mg day−1. Across age groups, berries were the top sources: blackberry (5–65%), cherry (2–24%), blueberry (2–13%) and raspberry (3–12%). There was a significant inverse association between anthocyanin intake and systolic BP (β = −0.04, F = 16.8, d.f. = 6, r2 = 0.05, P < 0.01) and diastolic BP (β = 0.01, F = 5.35, d.f. = 6, R2 = 0.013, P < 0.01), in models that adjusted for covariates. Conclusions In comparison with the world composite database, anthocyanin intake in the Australian population was above average [mean (SD): 24.17 (0.32) mg day−1 versus 18.05 (21.14) mg day−1]. Berries were the primary source of anthocyanins. Anthocyanin intake in older adults aged ≥50 years was inversely associated with BP.

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“…As the control bread also contained proteins, the results suggest that effects of the vegetable polyphenols alone or in synergy with bioactive peptides were stronger than similar interactions between wheat polyphenols and bioactive peptides. The results are consistent with a recent report that showed oral administration of an anthocyanin‐rich plum juice to human volunteers resulted in significant reductions in heart rate within a 24 h test period (Igwe et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Antihypertensive properties of aqueous extracts of vegetable leaf‐fortified bread after oral administration to spontaneously hypertensive rats

Alashi

Taiwo

Oyedele

et al. 2018

Int J of Food Sci Tech

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Summary This study investigated the potential cardiovascular health benefits of leavened bread produced from wheat flour that contained 1%, 2% and 3% additions of leafy vegetable powders obtained from Amaranthus viridis (AO), Solanum macrocarpon (SM) or Telfairia occidentalis (TO). Dried breads were extracted with water at 60 °C followed by analysis for total polyphenolic content (TPC), as well as in vitro inhibitions of angiotensin‐converting enzyme and renin activities. HPLC analysis of the bread extracts indicated the presence of mainly rutin, gallic acid, myricetin and caffeic acid. TPC of the vegetable‐fortified breads was significantly (P < 0.05) higher (5.8–7.6 mg gallic acid equivalent, GAE/g) than that of control bread (5.5 mg GAE/g). Oral administration of 100 mg dried extract/kg body weight to spontaneously hypertensive rats led to reductions (up to 42 mmHg) in systolic, diastolic and mean arterial blood pressure in comparison with 20 mmHg for the control bread.

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Anthocyanin-rich plum juice reduces ambulatory blood pressure but not acute cognitive function in younger and older adults: a pilot crossover dose-timing study

Cited by 46 publications

References 66 publications

Antihypertensive effect of aqueous polyphenol extracts of Amaranthusviridis and Telfairiaoccidentalis leaves in spontaneously hypertensive rats

Antihypertensive effect of aqueous polyphenol extracts of Amaranthusviridis and Telfairiaoccidentalis leaves in spontaneously hypertensive rats

Usual dietary anthocyanin intake, sources and their association with blood pressure in a representative sample of Australian adults

Antihypertensive properties of aqueous extracts of vegetable leaf‐fortified bread after oral administration to spontaneously hypertensive rats

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