Anthocyanins and Human Health—A Focus on Oxidative Stress, Inflammation and Disease

Speer, Hollie; D’Cunha, Nathan M.; Alexopoulos, Natalie I; McKune, Andrew J.; Naumovski, Nenad

doi:10.3390/antiox9050366

Cited by 137 publications

(94 citation statements)

References 77 publications

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“…Higher levels of both anthocyanins and antioxidant activity have also been reported in red dahlia flowers, as compared with white ones (Espejel et al, 2019). Anthocyanins are valuable molecules for functional food production as they have antioxidant, anti-inflammatory, and anti-apoptotic effects (Speer et al, 2020). Total polyphenol content was also higher in the red variety and the concentration was similar to that reported in pink begonia flowers (Chensom et al, 2019).…”

Section: Discussionsupporting

confidence: 56%

Combined effect of silicon and non-thermal plasma treatments on yield, mineral content, and nutraceutical proprieties of edible flowers of Begonia cucullata

Traversari¹,

Pistelli

Ministro³

et al. 2021

Plant Physiology and Biochemistry

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Edible flowers are becoming popular as a nutraceutical and functional food that can contribute to human nutrition with high antioxidant molecules and mineral elements. While comparative studies between different flower species have been performed, less is known about the best agronomical practices to increase yield and nutraceutical proprieties of blooms. Silicon stimulates plant resistance against stress and promotes plant growth while non-thermal plasma (NTP) technology has been applied for the disinfection and decontamination of water, as well as for increasing plant production and quality. The application of silicon and NTP technology through nutrient solution and spraying was investigated in edible flowers given that the combination of these treatments may play a role in promoting their nutritional and nutraceutical proprieties. The treatments were applied on two varieties of Begonia cucullata Willd. (white and red flowers) to explore their effects on different flower pigmentations. Plants with red flowers showed higher nutraceutical proprieties than the white ones but yielded a lower flower number. While the NTP treatment did not improve flower yield and quality, the silicon treatment increased anthocyanins and dry weight percentage in red flowers. NTP treatment increased zinc concentration, while it decreased potassium, magnesium, and manganese, and increased silicon concentration in white flowers. The combination of silicon and NTP showed negative effects on some nutraceutical proprieties of red flowers thus highlighting that the two treatments cannot be combined in edible flower production. In conclusion, the positive effect of silicon use in edible flower production has been demonstrated while the NTP technology showed contrasting results and its use should be explored in greater depth, including a consideration of its role in biotic attack prevention and reduced chemical input.

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Section: Discussionsupporting

confidence: 56%

Combined effect of silicon and non-thermal plasma treatments on yield, mineral content, and nutraceutical proprieties of edible flowers of Begonia cucullata

Traversari¹,

Pistelli

Ministro³

et al. 2021

Plant Physiology and Biochemistry

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“…The anthocyanins and other antioxidant components also inhibit oxidative stress and stress-sensitive signaling pathways. They have been proposed to attenuate ROS, especially by the ability to act as reducing agents in the electron-transfer reaction pathway [ 48 ]. It has been documented that the number of hydroxyl groups present on the glycosylated B-ring structure of anthocyanins is associated with their scavenging ability, and may influence their antioxidant capacity.…”

Section: Discussionmentioning

confidence: 99%

Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

Omelka

Blahová

Kováčová

et al. 2020

Animals

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Cornelian cherry (Cornus mas L.) is a medicinal plant with a range of biological features. It is often used as a nutritional supplement in the treatment of diabetes mellitus. Our study was aimed to first investigate the effects of Cornelian cherry pulp on bone quality parameters in Zucker diabetic fatty (ZDF) rats. Moreover, lipid-lowering properties of this fruit were also evaluated. Adult rats (n = 28) were assigned into four groups of seven individuals each: L group (non-diabetic lean rats), C group (diabetic obese rats), and E1 and E2 groups (diabetic obese rats receiving 500 and 1000 mg/kg body weight of Cornelian cherry pulp, respectively, for 10 weeks). Significantly lower levels of triglyceride, total cholesterol and alkaline phosphatase activity were determined in the E2 group versus the C group. A higher dose of Cornus mas also had a beneficial impact on femoral weight, cortical bone thickness, relative volume of trabecular bone and trabecular thickness. We observed elevated density of Haversian systems and accelerated periosteal bone apposition in both treated groups (E1 and E2). Our results clearly demonstrate that Cornelian cherry pulp has a favorable effect on lipid disorder and impaired bone quality consistent with type 2 diabetes mellitus in a suitable animal model.

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“…Flavonoid subclasses were calculated as the habitual daily intake (mg/day), estimated using the US Department of Agriculture (USDA) flavonoid content of foods database, according to previously described methods [ 42 , 43 ]. Commonly consumed US dietary sources of anthocyanins include fruits, such as berries, blackcurrants, red grapes, plums, and cherries, as well as red wine, fruit juices, and some vegetables, such as radishes [ 44 , 45 ]. Anthocyanins are further classified into six subclasses: pelargonidin, cyanidin, delphinidin, peonidin, petunidin, and malvidin.…”

Section: Methodsmentioning

confidence: 99%

Anthocyanin Intake and Physical Activity: Associations with the Lipid Profile of a US Working Population

et al. 2020

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While growing evidence exists on the independent associations between anthocyanins and physical activity on cardiovascular disease (CVD) risk determinants, the possible interaction between these exposures has not yet been studied. We aimed to study the potential synergism between anthocyanin intake and physical activity on lipid profile measures. This cross-sectional study was conducted among 249 US career firefighters participating in the Feeding America’s Bravest trial. Anthocyanin intake was calculated using a validated food frequency questionnaire (FFQ) and physical activity level by a validated questionnaire. Multivariable linear regression models determined the extent to which anthocyanin intake and physical activity predicted lipid parameters. Generalized linear models were used for joint effect and interaction analyses on the multiplicative and additive scales. Both anthocyanins and physical activity were independently inversely associated with total cholesterol:high density lipoprotein (HDL) cholesterol. Only physical activity was inversely associated with triglycerides, low density lipoprotein (LDL) cholesterol:HDL, and triglycerides (TG):HDL. Although the combined exposure of low anthocyanin intake and low physical activity was associated with lower (RR = 2.83; 95% CI: 1.42 to 5.67) HDL cholesterol <40 mg/dL, neither multiplicative (p = 0.72) nor additive interactions were detected (relative excess risk due to interaction (RERI): 0.02; 95% CI: −1.63 to 1.66; p = 0.98). Our findings provide insight on the potential synergism between anthocyanin intake and physical activity on the lipid profile.

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Anthocyanins and Human Health—A Focus on Oxidative Stress, Inflammation and Disease

Cited by 137 publications

References 77 publications

Combined effect of silicon and non-thermal plasma treatments on yield, mineral content, and nutraceutical proprieties of edible flowers of Begonia cucullata

Combined effect of silicon and non-thermal plasma treatments on yield, mineral content, and nutraceutical proprieties of edible flowers of Begonia cucullata

Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

Anthocyanin Intake and Physical Activity: Associations with the Lipid Profile of a US Working Population

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