Anthocyanins from Black Chokeberry Delayed Ageing-related Degenerative Changes in the Heart

Abstract

Aim: Aging is the greatest risk factor for most neurodegenerative diseases. Cardiovascular circulatory system is an important part of maintaining normal human life activities. The core of the aging process is DNA damage, a food additive called Anthocyanin which has shown high efficacy in preventing aging, We examine whether anthocyanins could keep young mice from accelerated ageing of the heart. Materials and Methods: In order to accelerate ageing, Mice of Kunming were injected with D-galactose and they were given anthocyanins of 20 and 40 mg/kg as an intervention. Results: The whole function and structure of heart were evaluated after eight weeks and the expression levels of genes involved in the DNA damage signalling pathway were evaluated through Western blot analysis. Reduction of the heart index and the heart tissue damage was delayed by Anthocyanins. it maintained the stability of the redox system in serum such as GSH-PX, T-SOD and MDA and heart tissue. In the DNA damage signalling pathway, the expression levels of sensors such as ATM and ATR and effectors such as Chk1 and Chk2 were reduced. Conclusion: Anthocyanins can be diffusely used to slow ageing-related deterioration of heart structure and function by inhibiting DNA damage in the field of health products.

Evaluation of Cardiovascular Effects of Carvacrol in a D-(+)-Galactose-Induced aging Model

“…2A and 2B) significant increase in fluorescence intensity by the DHE probe compared to the CTL group (CTL=100 ± 3.618%, n=5 and Dgal=167.7 ± 7.9%, n=5, respectively), suggesting an increase in the levels of reactive oxygen species (ROS) in the superior mesenteric artery of these animals. A similar result was found in the studies by Dehghani et al (2018) [31], XU et al (2019) [12], WU et al (2017) [32], and Chang et al (2017) [19], which used the D-galactose accelerated aging model, and it promoted an increase in fluorescence intensity by DHE by increasing ROS generation and oxidative stress in cardiovascular tissues of animals, in addition to decreasing the antioxidant capacity of the body. However, the levels of ROS in the carvacroltreated groups were significantly attenuated in the Dgal+C50 (138.8 ± 4.5%, n=5) and Dgal+C100 (130.0 ± 5.5%, n=5) groups (Fig.…”

“…Thus, this accelerated aging model is a reliable experimental aging model at the cardiovascular system level and can be widely used [9][10][11]. The exploration of biomarkers and the search for new therapeutic targets, especially those with antioxidant activity that can act to slow or reverse the aging process, has aroused much interest [12]. Natural products have been a constant inspiration for medication research and development.…”

Anthocyanins from Aronia melanocarpa Induce Apoptosis in Caco‐2 Cells through Wnt/β‐Catenin Signaling Pathway

“…Therefore, it plays an important role in anti-aging. [11] At present, it is important to establish linkages between AMA and inhibiting CRC, as only a few studies on the antitumor effect of AMA on CRC have been conducted till now.…”

“…AMA has an obvious effect on the decline of learning memory and neuromuscular coordination ability in the process of aging. Therefore, it plays an important role in anti‐aging [11] . At present, it is important to establish linkages between AMA and inhibiting CRC, as only a few studies on the antitumor effect of AMA on CRC have been conducted till now.…”

Antioxidative potential of Lactobacillus sp. in ameliorating D-galactose-induced aging

“…Aging may cause coronary heart diseases related to ROS overproduction and oxidative stress. Treatment with D-galactose has been found to decrease levels of antioxidant enzymes, for example, catalase (CAT), SOD, glutathione peroxidase (GSH-Px), nitric oxide synthase (NOS), and also the total antioxidant capacity, which triggers oxidative stress within the animals’ heart tissues by raising concentrations of nitric oxide (NO) and malondialdehyde (MDA) (Li et al 2005 ; Lei et al 2016 ; Dehghani et al 2018 ; Xu et al 2019 ). Moreover, D-galactose was shown to raise the weights of the left ventricle weight and whole heart, a phenomenon that is associated with aging and hypertrophy (Chen et al 2018 ).…”