Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells

Nizamutdinova, Irina Tsoy; Kim, Young Min; Chung, Jong Il; Shin, Sung Chul; Jeong, Yong-Kee; Seo, Han Geuk; Lee, Jae Heun; Chang, Ki Churl; Kim, Hye Jung

doi:10.1016/j.fct.2009.08.016

Cited by 110 publications

(66 citation statements)

References 29 publications

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“…Moreover, it must be emphasized that already after seven days, only UNCAJ and REF groups presented re-epithelialization, and no edema was verified. Studies demonstrated that the administration of antioxidants like vitamins C and E and anthocyanins to mice with skin wounds led to better healing, increased angiogenesis, and fibroblasts and keratinocytes induction 48,49 It must also be highlighted the role of other phenolic compounds, such as tannins, which may have a wound healing activity through a complex regulation involving angiogenesis and FP.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and wound healing potential of cashew apple juice (Anacardium occidentale L.) in mice

Vasconcelos

Gomes-Rochette

Oliveira

et al. 2015

Exp Biol Med (Maywood)

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Cashew apple is a tropical pseudofruit consumed as juice due to its excellent nutritional and sensory properties. In spite of being well known for its important antioxidant properties, the cashew apple has not been thoroughly investigated for its therapeutic potential. Thereby, this study evaluated the antioxidant capacity, anti-inflammatory, and wound-healing activities of cashew apple juice. Juices from ripe and immature cashew apples were analyzed for antioxidant, anti-inflammatory, and wound-healing properties. Those were evaluated in murine models of xylene-induced ear edema and wound excision. Swiss mice were treated with cashew juice by gavage. Edema thickness was measured and skin lesions were analyzed by planimetry and histology. Both antioxidant content and total antioxidant activity were higher in ripe cashew apple juice (RCAJ) than in unripe cashew apple juice (UNCAJ). The UNCAJ presented the main anti-inflammatory activity by a significant inhibition of ear edema (66.5%) when compared to RCAJ (10%). Moreover, UNCAJ also showed the best result for wound contraction (86.31%) compared to RCAJ (67.54%). Despite of higher antioxidant capacity, RCAJ did not promote better anti-inflammatory, and healing responses, which may be explained by the fact that treatment increased antioxidants level leading to a redox ''imbalance'' turning down the inflammatory response modulation exerted by reactive oxygen species (ROS). The results suggest that UNCAJ presents a greater therapeutic activity due to a synergistic effect of its phytochemical components, which improve the immunological mechanisms as well as an optimal balance between ROS and antioxidants leading to a better wound healing process.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and wound healing potential of cashew apple juice (Anacardium occidentale L.) in mice

Vasconcelos

Gomes-Rochette

Oliveira

et al. 2015

Exp Biol Med (Maywood)

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“…Anthocyanins have potent antioxidant power (Croft, 1998;Tsuda et al, 1994) and are related to a broad range of beneficial effects in human health and disease prevention. They can promote healthy vision (Ghosh & Konishi, 2007) and dermal health (Nizamutdinova et al, 2009) and are proposed to exhibit positive effects on cardiovascular (Diaz, Frei, Vita, & Keaney, 1997;Zafra-Stone et al, 2007), neuroprotective (Lau, Shukitt-Hale, & Joseph, 2006), anticarcinogenic (Seeram et al, 2006) and antidiabetic (Zafra-Stone et al, 2007;Ghosh & Konishi, 2007) properties.…”

Section: Introductionmentioning

confidence: 98%

Kinetic study on the thermal and pressure degradation of anthocyanins in strawberries

et al. 2010

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“…79,80 Physiological angiogenesis by oxidative stress Physiological angiogenesis in adult organisms is required for tissue repair and remodeling processes, such as wound healing, skeletal remodeling, and female reproduction. 2 In wound healing, angiogenesis is induced by tissue hypoxia and ROS, which either stimulate macrophages, fibroblasts, endothelial cells, and keratinocytes to produce VEGF, 6,43,[81][82][83] or operate in a VEGFindependent fashion. 59 During endochondral ossification during longitudinal bone growth, increasing ROS promote chondrocyte hypertrophy, which, in turn, induces angiogenesis.…”

Section: Vegf-independent Mechanisms Of Oxidation-induced Angiogenesismentioning

confidence: 99%

Oxidative stress in angiogenesis and vascular disease

Kim

Byzova

2014

Blood

549

388

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Despite the damaging effect on tissues at a high concentration, it has been gradually established that oxidative stress plays a positive role during angiogenesis. In adults, physiological or pathological angiogenesis is initiated by tissue demands for oxygen and nutrients, resulting in a hypoxia/reoxygenation cycle, which, in turn promotes the formation of reactive oxygen species (ROS). The ROS can be generated either endogenously, through mitochondrial electron transport chain reactions and nicotinamide adenine dinucleotide phosphate oxidase, or exogenously, resulting from exposure to environmental agents, such as ultraviolet or ionizing radiation. In many conditions, ROS promotes angiogenesis, either directly or via the generation of active oxidation products, including peroxidized lipids. The latter lipid metabolites are generated in excess during atherosclerosis, thereby linking atherogenic processes and pathological angiogenesis. Although the main mechanism of oxidative stress-induced angiogenesis involves hypoxia-inducible factor/vascular endothelial growth factor (VEGF) signaling, recent studies have identified several pathways that are VEGF-independent. This review aims to provide a summary of the past and present views on the role of oxidative stress as a mediator and modulator of angiogenesis, and to highlight newly identified mechanisms.

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Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells

Cited by 110 publications

References 29 publications

Anti-inflammatory and wound healing potential of cashew apple juice (Anacardium occidentale L.) in mice

Anti-inflammatory and wound healing potential of cashew apple juice (Anacardium occidentale L.) in mice

Kinetic study on the thermal and pressure degradation of anthocyanins in strawberries

Oxidative stress in angiogenesis and vascular disease

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