Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Naseri, Rozita; Farzaei, Fatemeh; Haratipour, Pouya; Nabavi, Seyed Fazel; Habtemariam, Solomon; Farzaei, Mohammad Hosein; Khodarahmi, Reza; Tewari, Devesh; Momtaz, Saeideh

doi:10.3389/fphar.2018.01310

Cited by 88 publications

(62 citation statements)

References 182 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of anthocyanin supplementation on the body weight remain controversial [72,73]. However, our data confirmed that anthocyanins are health-promoting bioactive compounds [74]. Several studies have shown that phytocompounds found in fruits and vegetables have beneficial health effects, such as prevention of cancer, cardiovascular diseases, and obesity [75].…”

Section: Discussionsupporting

confidence: 59%

Brain Alterations in High Fat Diet Induced Obesity: Effects of Tart Cherry Seeds and Juice

et al. 2020

View full text Add to dashboard Cite

Evidence suggests that obesity adversely affects brain function. High body mass index, hypertension, dyslipidemia, insulin resistance, and diabetes are risk factors for increasing cognitive decline. Tart cherries (Prunus Cerasus L.) are rich in anthocyanins and components that modify lipid metabolism. This study evaluated the effects of tart cherries on the brain in diet-induced obese (DIO) rats. DIO rats were fed with a high-fat diet alone or in association with a tart cherry seeds powder (DS) and juice (DJS). DIO rats were compared to rats fed with a standard diet (CHOW). Food intake, body weight, fasting glycemia, insulin, cholesterol, and triglycerides were measured. Immunochemical and immunohistochemical techniques were performed. Results showed that body weight did not differ among the groups. Blood pressure and glycemia were decreased in both DS and DJS groups when compared to DIO rats. Immunochemical and immunohistochemical techniques demonstrated that in supplemented DIO rats, the glial fibrillary acid protein expression and microglial activation were reduced in both the hippocampus and in the frontal cortex, while the neurofilament was increased. Tart cherry intake modified aquaporin 4 and endothelial inflammatory markers. These findings indicate the potential role of this nutritional supplement in preventing obesity-related risk factors, especially neuroinflammation.

show abstract

Section: Discussionsupporting

confidence: 59%

Brain Alterations in High Fat Diet Induced Obesity: Effects of Tart Cherry Seeds and Juice

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Hence, we assumed that anthocyanins in RRB might be responsible for the increase in plasma antioxidant capacity. It has been reported that cyanidin-3-glucoside and peonidin-3-glucoside, the major anthocyanin in RRB, act as a natural antioxidant with high reactivity toward reactive oxygen species (ROS) because of its capability to donate hydrogen atoms or transfer electron from several hydroxyl groups to free radicals and unpaired electrons [30]. However, increases in plasma antioxidant capacity might be accompanied with other bioactive polyphenols in RRB.…”

Section: Discussionmentioning

confidence: 99%

Postprandial Glycemia, Insulinemia, and Antioxidant Status in Healthy Subjects after Ingestion of Bread made from Anthocyanin-Rich Riceberry Rice

Chusak

Pasukamonset²,

Chantarasinlapin

2020

Nutrients

View full text Add to dashboard Cite

Riceberry rice, a gluten-free grain, contains many nutrient components, including carbohydrates, proteins, certain fatty acids, and micronutrients, as well as bioactive non-nutrient compounds, such as polyphenolic compounds. This study aimed to evaluate the effect of bread made from anthocyanin-rich Riceberry rice on the postprandial glycemic response, glucagon-like peptide-1 (GLP-1), antioxidant status, and subjective ratings of appetite. In the crossover design, 16 healthy participants (six men and 10 women) completed four sessions involving blood collection in the fasting state and at 30, 60, 90, 120, 150, and 180 min after food consumption (50 g of available carbohydrate) in a randomized order: 1) glucose solution, 2) wheat bread (WB), 3) Riceberry rice bread (RRB), and 4) Hom Mali bread (HMB). Consumption of RRB resulted in significantly lower postprandial plasma glucose concentration at 30 and 60 min when compared to HMB. No difference in postprandial glucose concentration between RRB and WB was observed. In addition, postprandial plasma insulin showed a significant decrease in the group which received RRB at 15 and 60 min, as compared to HMB. In comparison with 50 g of glucose, as a reference, the glycemic index (GI) of RRB, WB, and HMB was 69.3 ± 4.4, 77.8 ± 4.6, and 130.6 ± 7.9, respectively. Interestingly, the ferric-reducing ability of plasma (FRAP) level was shown to significantly increase after consumption of RRB. In the meantime, a significant decrease in the postprandial FRAP level was also observed following an intake of WB and HMB. All breads caused increases in the postprandial plasma protein thiol group and had similar effects on hunger, fullness, desire to eat, and satiety ratings. However, consumption of RBB, WB, and HMB did not change plasma GLP-1 and malondialdehyde (MDA) levels when compared to the baseline. The findings suggest that anthocyanin-rich Riceberry rice can be a natural ingredient for gluten-free bread which reduced glycemic response together with improvement of antioxidant status in healthy subjects.

show abstract

“…Anthocyanins improve cardiovascular health, as shown by epidemiological studies leading to clinical studies showing improved surrogate markers of cardiovascular health, such as hypertension, lipid profiles and endothelial function with increased effects in overweight individuals [26]. Thus, anthocyanins are important in the potential prevention and reversal of metabolic syndrome, including obesity and inflammation [27,28]. These clinical studies have been supported by animal studies, including our reports in the same model as this study on purple carrots, Queen Garnet plums, purple maize and chokeberries [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats

et al. 2020

View full text Add to dashboard Cite

Saskatoon berry (Amelanchier alnifolia) is a potential functional food containing anthocyanins and flavonols, as well as ellagitannins and phenolic acids. We have determined the potential therapeutic effects of Saskatoon berry in diet-induced metabolic syndrome. Nine- to ten-week-old male Wistar rats were randomly assigned to four groups. Two groups were fed on control diets, either corn starch (C) or high-carbohydrate, high-fat diet (H) respectively, for 16 weeks. Two further groups were fed on C or H diet for 16 weeks with Saskatoon berry powder added to the diet for the final 8 weeks (CSSK, HSSK). After 16 weeks, H rats showed symptoms of metabolic syndrome, including increased body weight, visceral adiposity, systolic blood pressure, cardiac fibrosis, plasma concentrations of triglycerides and non-esterified fatty acids, and plasma activities of alanine transaminase and aspartate transaminase. Saskatoon berry intervention normalised body weight and adiposity, improved glucose tolerance, decreased systolic blood pressure, improved heart and liver structure and function with decreased infiltration of inflammatory cells, and decreased plasma total cholesterol. Further, Saskatoon berry normalised liver expression of hexokinase 1 and glycogen phosphorylase and increased glucose 6-phosphatase relative to H rats. These results suggest that Saskatoon berry regulates glycolysis, gluconeogenesis and glycogenesis to improve metabolic syndrome.

show abstract

Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Cited by 88 publications

References 182 publications

Brain Alterations in High Fat Diet Induced Obesity: Effects of Tart Cherry Seeds and Juice

Brain Alterations in High Fat Diet Induced Obesity: Effects of Tart Cherry Seeds and Juice

Postprandial Glycemia, Insulinemia, and Antioxidant Status in Healthy Subjects after Ingestion of Bread made from Anthocyanin-Rich Riceberry Rice

Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats

Contact Info

Product

Resources

About