Anthology of stroke epidemiology in the 20th and 21st centuries: Assessing the past, the present, and envisioning the future

Feigin, Valery L.

doi:10.1177/1747493019832996

Cited by 66 publications

(53 citation statements)

References 63 publications

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“…Over the past decades, there has been growing concern on the increasing incidence and prevalence of stroke and its attendant high morbidity in developing countries [1,2]. Arising from acute focal or global injury to the central nervous system by a vascular cause, stroke could result in considerable neurological deficits on its survivor [2].…”

Section: Background Of the Studymentioning

confidence: 99%

The development of a return to work intervention programme for stroke survivor (SReTWIP): a Delphi survey

2020

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Background: Even though clearly defined pathways for vocational re-entry are well recognized for conditions such as mental health, musculoskeletal dysfunction (MSD) and traumatic brain injury (TBI), none has been identified for stroke. There has been a lack of consensus regarding such clear pathways to vocational re-entry and the essential contents of return to work (RTW) interventions for stroke survivors. As part of a larger study aimed to design a RTW programme for stroke survivors, this study describes the concluding process through which Stroke Return to Work Intervention Programme (SReTWIP) was developed. Methods: Experts in the field of neurorehabilitation and vocational rehabilitation (VR) from 6 countries participated in this 3-round Delphi survey via e-mail. Concept mapping was used to triangulate findings from the Delphi with previous phases of the larger study. Content thematic analysis was conducted on qualitative data while descriptive statistic was used to analyze quantitative data.Results: Fifteen experts with a mean age and mean duration of practice of 44.73 ± 9.48 years and 18.26 ± 8.71 years respectively participated in this study. The developed RTW programme (SReTWIP) is a 12 week programme that consisted of four interconnected phases of intervention viz.: an assessment phase, clinic-based work and non-work specific intervention phase, a work test placement phase and a client full participation in worker role phase. The experts agreed on a set of implementation strategies that included the use of interdisciplinary team, the tailoring of intervention to meet stroke survivor's need, as well as the use of case management approach.Conclusion: The SReTWIP is the first step in developing a VR pathway that can ultimately enhance the RTW rates and quick resumption of the worker role of stroke survivors. The stroke survivor can move along the different phases of the SReTWIP after achieving competency in a preceding phase. Future work will include a feasibility study with other key stakeholders involved in RTW such as employers, informal caregivers and stroke survivors before its implementation.

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Section: Background Of the Studymentioning

confidence: 99%

The development of a return to work intervention programme for stroke survivor (SReTWIP): a Delphi survey

2020

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“…Stroke is the leading cause of lethality and permanent disability throughout the world (Feigin, 2019). Presently, although common approaches, such as medical thrombolysis and mechanical thrombectomy, have been applied to treat stroke, delayed thrombolytic treatment with recombinant tissue plasminogen activator (tPA) and poor outcomes still occur.…”

Section: Introductionmentioning

confidence: 99%

Plasmacytoid Dendritic Cells Protect Against Middle Cerebral Artery Occlusion Induced Brain Injury by Priming Regulatory T Cells

Chen

Chencheng

Liu

et al. 2020

Front. Cell. Neurosci.

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Regulatory T cells (Tregs) play an anti-inflammatory effect to protect against ischemic stroke. Plasmacytoid dendritic cells (pDCs) can induce regulatory T cells tolerance in sterile-inflammation conditions. However, whether and how pDCs-mediated Tregs response play a part in the pathology of ischemic stroke remains unclear. In this study, we showed that pDCs were increased in the brain of middle cerebral artery occlusion (MCAO) mice. Depletion of pDCs with 120G8 exacerbated MCAO-induced brain injury, peripheral pro-inflammation response and decreased the systemic Tregs in mice. Furthermore, the data of mixed lymphocyte reaction (MLR) in vitro demonstrate that splenic pDCs from MCAO mice can significantly promote Tregs proliferation, accompanying with the increased expression of indoleamine 2,3-dioxygenase 1 (IDO1) on pDCs. Taken together, the findings here suggested that under the pathologic state of stroke, pDCs protect against MCAO-induced brain injury by priming Tregs, illustrating that pDCs represented as a therapeutic target for the prevention of ischemic brain injury.

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“…In 2016, 10.1% of global deaths were caused by stroke, and there were 13.7 million new stroke cases worldwide with an overall cost of 116 million disability-adjusted life years [ 2 , 3 ]. Although the global incidence and mortality rates of stroke have decreased during the past 20 years, the absolute number of people suffering a stroke has almost doubled from 1990 to 2016, and the absolute number of stroke-related deaths increased by 20% over the same time period, stroke mortality being now ranked as the second leading cause of death, after ischemic heart disease [ 4 , 5 ]. Current estimates predict that without specific measures, the global burden of stroke will continue to increase during the next decades [ 1 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Outcomes of Patients with Intracerebral Hemorrhage – A Feasibility Study on Romanian Patients

et al. 2020

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Intracerebral hemorrhage is a significant public health problem, as it is a disease associated with overwhelming mortality and disability. We performed a retrospective feasibility study of patients admitted with acute intracerebral hemorrhage in our department for four months. Our aims were to identify peculiarities of the risk factors, demographic and clinical characteristics of intracerebral hemorrhage patients from our population, to estimate a feasible recruitment rate for a larger prospective study of patients with intracerebral hemorrhage and to analyze and correct potential drawbacks in the methodology of a more extensive prospective study of patients with intracerebral hemorrhage hospitalized in our department. During the study period, we admitted 53 patients with intracerebral hemorrhage in our department. The mean age of the patients was 69.1 years, and 53% were men. Arterial hypertension was the most common etiologic factor leading to intracerebral hemorrhage. 50.01% of patients died during hospitalization, 31.19% were discharged with significant disability, and 18.8% had a favorable short-term outcome. Higher hematoma volumes, male sex, deep location of the hemorrhage, and age between 51 and 60 years were factors associated with an unfavorable short-term outcome.

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Anthology of stroke epidemiology in the 20th and 21st centuries: Assessing the past, the present, and envisioning the future

Cited by 66 publications

References 63 publications

The development of a return to work intervention programme for stroke survivor (SReTWIP): a Delphi survey

The development of a return to work intervention programme for stroke survivor (SReTWIP): a Delphi survey

Plasmacytoid Dendritic Cells Protect Against Middle Cerebral Artery Occlusion Induced Brain Injury by Priming Regulatory T Cells

Clinical Characteristics and Outcomes of Patients with Intracerebral Hemorrhage – A Feasibility Study on Romanian Patients

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