Anthracycline nano-delivery systems to overcome multiple drug resistance: A comprehensive review

Ma, Ping; Mumper, Russell J.

doi:10.1016/j.nantod.2013.04.006

Cited by 125 publications

(85 citation statements)

References 147 publications

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“…Chemotherapy is an important component in the treatment of patients with late HCC. However, drug-resistance minimizes the effectiveness of such therapy in a large number of patients (5)(6)(7)(8). Drug resistance is a complex phenomenon, with multiple factors and mechanisms contributing to the resistance (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…However, drug-resistance minimizes the effectiveness of such therapy in a large number of patients (5)(6)(7)(8). Drug resistance is a complex phenomenon, with multiple factors and mechanisms contributing to the resistance (5)(6)(7)(8). Although advances in the fields of resistance-associated proteins (drug transporters, metabolic enzymes and target molecules) and DNA repair or cell apoptosis pathways, to date, there is no validated drug-response/resistant biomarker available in clinical settings, and the underlying mechanisms of acquisition of resistance to chemotherapeutic agents remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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miR-222 regulates sorafenib resistance and enhance tumorigenicity in hepatocellular carcinoma

Liu

Zhang

et al. 2014

International Journal of Oncology

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Abstract. The miR-222 cluster has been demonstrated to function as oncomiR in human hepatocellular carcinoma (HCC). miR-222 confers chemotherapy drug resistance in various cancers, including HCC. However, the effects and mechanisms by which miR-222 regulates liver tumorigenicity and confers sorafenib (SOR) resistance remain unclear. Here we first investigated the miR-222 effect on proliferation, cell cycle, apoptosis, migration and invasion of HCC. Our results demonstrated that miRNA inhibitors specially targeting miR-222 significantly suppressed cellular proliferation, migration, invasion and G1/S transition of the cell cycle, and induced cell apoptosis in HepG2 cells. In addition, we investigated whether miR-222 confers SOR resistance in HepG2 cells to explore it roles in acquisition of drug resistance. The results showed that miR-222 inhibitors induced sensitivity to the antitumor effect of sorafenib in human HepG2 cells. Importantly, our study also showed that miR-222 could regulate the expression of phosphorylation PI3K and AKT, which might contribute to miR-222 conferred SOR resistance in HepG2 cells. In conclusion, this study demonstrates that miR-222 can promote cell proliferation, migration and invasion, and decrease cell apoptosis, as well as enhance the resistance of HCC cells to sorafenib miR-222 through activating the PI3K/AKT signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

miR-222 regulates sorafenib resistance and enhance tumorigenicity in hepatocellular carcinoma

Liu

Zhang

et al. 2014

International Journal of Oncology

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“…Despite considerable recent progress in the understanding of the mechanisms underlying bacterial infections, and in the development of nanostructured materials displaying antibacterial properties and activity against biofilms [1], [5], [6], [7] and [8], the quest to design and fabricate new antibacterial nanostructures remains a high research priority. Nanoparticles have been considered as affective solution to fight against bacterial infections [4], [9], [10], [11], [12], [13], [14] and [15]. Such nanostructures allow the concentration of antibacterial agents and functions on their surface to deliver polyvalent effects.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of menthol modified nanodiamond particles

Turcheniuk

Raks

Issa

et al. 2015

Diamond and Related Materials

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Advances in nanotechnology have seen the development of several microbiocidal nanoparticles displaying activity against biofilms. These applications benefit from one or more combinations of the nanoparticle properties. Nanoparticles may indeed concentrate drugs on their surface resulting in polyvalent effects and improved efficacy to fight against bacteria. Nanodiamonds (NDs) are among the most promising new materials for biomedical applications. We elucidate in this paper the effect of menthol modified nanodiamond (ND-menthol) particles on bacterial viability against Grampositive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. We show that while ND-menthol particles are non-toxic to both pathogens, they show significant antibiofilm activity. The presence of ND-menthol particles reduces biofilm formation more efficiently than free menthol, unmodified oxidized NDs and ampicillin, a commonly used antibiotic. Our findings might be thus a step forward towards the development of alternative non antibiotic based strategies targeting bacterial infections.

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“…Unfortunately, this formulation does not address the MDR problem. To date, many nanodelivery systems have been developed and reported and include liposomes, polymeric, solid lipid, mesoporous silica and magnetic nanoparticles, and polymer-drug conjugates to effectively circumvent MDR both in vitro and in vivo and some of these systems have even been advanced to clinical trials [33]. Vincristine and vinblastine are alkaloids from Catharanthus roseus (periwinkle), a plant of the Apocynaceae family.…”

Section: Other Anticancer Natural Drugsmentioning

confidence: 99%

Improving on Nature: The Role of Nanomedicine in the Development of Clinical Natural Drugs

et al. 2017

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Natural products have been used as a major source of drugs for millennia, and about half of the pharmaceuticals in use today are derived from natural products. However, their efficacy can be limited because of their low hydrophilicity and intrinsic dissolution rate(s), or physical/chemical instability. In addition, they can present scarce absorption, poor pharmacokinetics and bioavailability, scarce biodistribution, first-pass metabolism, trivial penetration and accumulation in the organs of the body, or low targeting efficacy. Novel nanoformulations based on drug delivery systems, namely nanoparticles, micelles, and vesicles, offer significant promise in overcoming these limitations. Nowadays, nanomedicine is crucial in developing appropriate therapeutic treatments of essential drugs, specifically antitumor and antiparasistic agents (i.e., Taxol, vincristine, camptothecin, doxorubicin, artemisinin) and other emerging molecules with pleiotropic functions (i.e., resveratrol, curcumin, salvianolic acid B, honokiol). Additionally, the number of nanoformulations developed with flavonoids, in particular rutin, quercetin, silymarin, and green tea catechins, is constantly increasing, and a significant number of publications have appeared in the last decade pertaining to nanoformulations based on extracts and essential oils. Most of these studies report very promising nanoformulations with sustained release and improved bioavailability at much lower doses than conventional preparations, and in many cases, also a better safety profile.

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Anthracycline nano-delivery systems to overcome multiple drug resistance: A comprehensive review

Cited by 125 publications

References 147 publications

miR-222 regulates sorafenib resistance and enhance tumorigenicity in hepatocellular carcinoma

miR-222 regulates sorafenib resistance and enhance tumorigenicity in hepatocellular carcinoma

Antimicrobial activity of menthol modified nanodiamond particles

Improving on Nature: The Role of Nanomedicine in the Development of Clinical Natural Drugs

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