Anthraquinone and L-amino Acid Derivatives Schiff Base Cu(II) Complexes as a Mediator between Cathode of Biofuel Cell and Oxygen-reducing Laccase

Chiral Recognition of Azo-Schiff Base Ligands, Their Cu(II) Complexes, and Their Docking to Laccase as Mediators

“…In detail, a slight increase in current was observed for 1 and 2 in laccase, while a considerable increase in current was observed for 3 in laccase. Thus, it is considered that the oxygen reduction reaction of laccase was further promoted by the molecular orientation of the appropriate stereochemical molecules [9,10]. (1) (2) (3) Figure 7.…”

“…In this case, a redox substance called a mediator is generally used for electron transfer between the electrode and laccase [2]. In order to facilitate electron transfer between the electrode and the oxygen reductase in the biofuel cell cathode, our laboratory studied the use of Schiff base metal complexes as mediators [8][9][10][11]. Mediators are required to be able to fit to the hydrophobic pocket sites on the laccase surface to supply electrons to the electron accepting T1 site inside the laccase molecule.…”

“…Mediators are required to be able to fit to the hydrophobic pocket sites on the laccase surface to supply electrons to the electron accepting T1 site inside the laccase molecule. We have searched for methods to introduce not only central metal ions (Cu, Mn), but also redox groups of anthraquinone [8,9] and polarization orientation of azobenzene [10,11], to organic ligands. However, whether photoisomerization and photo-induced orientation of the azobenzene moiety is effective for increasing current, and what the appropriate way to fit a complex to laccase is, are still unknown.…”

“…It was found that chiral molecular recognition resulting from spontaneous resolution could be observed for the racemic organic ligand. oxygen reductase in the biofuel cell cathode, our laboratory studied the use of Schiff base metal complexes as mediators [8][9][10][11]. Mediators are required to be able to fit to the hydrophobic pocket sites on the laccase surface to supply electrons to the electron accepting T1 site inside the laccase molecule.…”

Computational Design of Azo-anthraquinone Schiff Base Mn Complexes as Mediators for Biofuel Cell Cathode

“…To improve this electron transfer, we have investigated several types of metal complexes as mediators between the electrode and laccase [5][6][7][8][9][10][11]. Molecular docking of suitable compound (both ligands and complexes) to the hydrophobic pocket of laccase may be useful in predicting the redox activity and their utility in biofuel cells [8,9]. Presence of noncoordinating, non-innocent substituent to the ligand backbone in the metal ligand or complex may be induced by the polarized UV-light to control the rate of redox processes.…”