Anthraquinones in Ventilago species

Rao, Bhattiprolu Kesava; Hanumaiah, T.; Rao, Ch. Pulla; Rao, G. Venkateswara; Rao, K.V.; Thomson, R. H.

doi:10.1016/0031-9422(83)80170-8

Cited by 33 publications

(18 citation statements)

References 11 publications

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“…Therefore, these compounds might be responsible for the increase of anti-proliferative activity of MF in comparing to its ME, whereas the other 3 fractions (HF, BF, and WF) showed no activity. However, the anti-proliferative constituents in Fibraurea tinctoria, Ventilago denticulata and Psophocarpus tetragonolobus were not clearly identified, whereas furanoditerpenoid, anthraquinone and proteins have been found in these plants, respectively (Rao et al, 1983;Ganguly and Singh, 1999;Su et al, 2008). This present study has first described the anti-proliferative activities of the three plants including Fibraurea tinctoria, Ventilago denticulata and Psophocarpus tetragonolobus on human colon cancer cell line (HT-29).…”

Section: Discussionmentioning

confidence: 71%

In vitro anti-proliferative activity on colon cancer cell line (HT-29) of Thai medicinal plants selected from Thai/Lanna medicinal plant recipe database “MANOSROI III”

Manosroi

Akazawa

Akihisa

et al. 2015

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 71%

In vitro anti-proliferative activity on colon cancer cell line (HT-29) of Thai medicinal plants selected from Thai/Lanna medicinal plant recipe database “MANOSROI III”

Manosroi

Akazawa

Akihisa

et al. 2015

Journal of Ethnopharmacology

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“…Phytochemical reports on the root bark of V. madraspatana show the presence of various anthraquinones, including ventinone-A, B, chrysophanol, physcion, emodin, islandicin, xanthorin and xanthorin-5-methyl ether (Kesava Rao et al, 1983). Naphthalene derivatives and naphthoquinones, such as ventilaginone, ventilagol, maderone, cordeauxione and isocordeauxione, are also reported from the root bark of this plant (Hanumaiah et al, 1985a;Hanumaiah et al, 1985b).…”

Section: Introductionmentioning

confidence: 97%

Evaluation of the antibacterial activity ofVentilago madraspatana Gaertn.,Rubia cordifolia Linn. andLantana camara Linn.: isolation of emodin and physcion as active antibacterial agents

2005

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The antibacterial activity of the extracts of Ventilago madraspatana stem-bark, Rubia cordifolia root and Lantana camara root-bark, prepared with solvents of different polarity, was evaluated by the agar-well diffusion method. Twelve bacteria, six each of gram-positive and gram-negative strains, were used in this study. Chloroform and ethanol extracts of V. madraspatana showed broad-spectrum activity against most of the bacteria except S. aureus, E. coli and V. cholerae. On the other hand, the activity of the chloroform and methanol extracts of R. cordifolia and L. camara was found to be more specific towards the gram-positive strains, although gram-negative P. aeruginosa was also inhibited by the methanol extracts of both these plants in a dose dependent manner. The water extracts of V. madraspatana and L. camara were found to be inactive, while that of R. cordifolia was significantly active against B. subtilis and S. aureus compared with streptomycin and penicillin G used as standards. In the course of bio-assay guided fractionation, emodin and physcion were isolated for the first time from the stem-bark of V. madraspatana. It was noteworthy to find the MICs of emodin in the range 0.5-2.0 microg/mL against three Bacillus sp. Both the anthraquinonoid compounds inhibited P. aeruginosa, emodin being more effective, showing an MIC of 70 microg/mL.

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“…denticulata (or V . calyculata ),[8 – 13] they have rarely been evaluated for biological activities. Moreover, recent studies revealed that crude extracts of V .…”

Section: Introductionmentioning

confidence: 99%

Naphthalene Derivatives and Quinones from Ventilago denticulata and Their Nitric Oxide Radical Scavenging, Antioxidant, Cytotoxic, Antibacterial, and Phosphodiesterase Inhibitory Activities

Molee

Phanumartwiwath

Kesornpun

et al. 2018

Chemistry & Biodiversity

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New naphthalene derivatives (1 and 2) and a new isomer (3) of ventilagolin, together with known anthraquinones, chrysophanol (4), physcion or emodin 3-methyl ether (5), and emodin (6), were isolated from vines of Ventilago denticulata. The isolated compounds exhibited cytotoxic activity with IC values of 1.15 - 40.54 μg/ml. Compounds 1 - 3 selectively exhibited weak antibacterial activity (MIC values of 200.0 - 400.0 μg/ml), while emodin (6) displayed moderate antibacterial activity with MIC value of 25.0 μg/ml. The isolated compounds showed nitric oxide and DPPH radical scavenging activities. Compounds 1 - 3 and 6 exhibited weak xanthine oxidase inhibitory activity, while emodin (6) acted as an aromatase inhibitor with the IC value of 10.1 μm. Compounds 1 and 2 exhibited phosphodiesterase 5 inhibitory activity with IC values of 8.28 μm and 6.48 μm, respectively.

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Anthraquinones in Ventilago species

Cited by 33 publications

References 11 publications

In vitro anti-proliferative activity on colon cancer cell line (HT-29) of Thai medicinal plants selected from Thai/Lanna medicinal plant recipe database “MANOSROI III”

In vitro anti-proliferative activity on colon cancer cell line (HT-29) of Thai medicinal plants selected from Thai/Lanna medicinal plant recipe database “MANOSROI III”

Evaluation of the antibacterial activity ofVentilago madraspatana Gaertn.,Rubia cordifolia Linn. andLantana camara Linn.: isolation of emodin and physcion as active antibacterial agents

Naphthalene Derivatives and Quinones from Ventilago denticulata and Their Nitric Oxide Radical Scavenging, Antioxidant, Cytotoxic, Antibacterial, and Phosphodiesterase Inhibitory Activities

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