Anthro-demographic, clinico-pathological and biochemical risk factors in cervical cancer

Abstract

Background: In India, cervical cancer (CaCx) ranks second with >1.2 lakh new cases and >77,000 deaths. The main causing agent of cervical cancer is human papillomavirus (HPV). Recently, anthro-demographic and clinico-pathological factors have been implicative of cancer development and progression. Objective: To evaluate the association of anthro-demographic, clinico-pathological and biochemical risk factors in cervical cancer. Methods: CaCx patients were tested for HPV infection using conventional PCR. Anthro-demographic and clinico-pathological characteristics were recorded and samples from patients (n=103) and healthy women (n=108) were analyzed for lipid profile, serum urea, creatinine and uric acid using commercial kits. Statistical analysis was done using SPSS (ver.21.0) and GraphPad. Results: Out of 103 CaCx patients, 86 were HPV+ve and 17 HPV-ve. Anthro-demographic factors like literacy, socio-economic status and obstetrics were found significantly associated with cervical cancer. BMI was associated with cervical cancer (1.18 folds higher risk). Total cholesterol (TC); triglycerides (TG); high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were found significantly associated with an increased adjusted OR in CaCx patients. Urea levels were found significantly higher in patients (1.11 folds crude OR vs 1.31 adjusted OR). Similarly, creatinine levels were significantly higher in patients (2.64 folds crude OR vs 3.37 adjusted OR).