The microdosing of mind-altering substances, like LSD and magic mushrooms, is a trend among young creatives, who report enhanced creativity, improved focus, and other productivity-enhancing effects. This chapter, Chemical Creativity, describes how both users and researchers have been exploring the range of effects of microdosing, including through more experimental ethnographic research. Using virtual ethnography, we analyzed drug users’ narratives of their personal experiences, practices, and motivations with microdosing. We also collaborated with participants using online platforms focused on drug experimentation to generate data, combining their collective experiences while acknowledging individual expertise. Finally, we reviewed research on clinical trials that compare the effects of psychoactive substances, like LSD, with placebos. What emerges is a clearer picture of the benefits of microdosing, how dosages are tweaked, and how users engage in “harm reduction from below” by spreading their cautionary tales within the microdosing world. In so doing, we offer a glimpse into how this relatively new practice develops, as it gains popularity with both laypeople and the academic and scientific communities.