Anthropometric factors and Breslow thickness: prospective data on 2570 cases of cutaneous melanoma in the population-based Janus Cohort

Stenehjem, Jo Steinson; Veierød, Marit B.; Nilsen, Lill Tove Norvang; Ghiasvand, Reza; Johnsen, Bjørn; Grimsrud, Tom Kristian; Babigumira, Ronnie; Støer, Nathalie C.; Rees, Judy R.; Robsahm, Trude Eid

doi:10.1111/bjd.16825

Cited by 19 publications

(16 citation statements)

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“…Smoking was shown to be associated with increased Breslow thickness: to our knowledge this is previously unreported in a large study (Grange et al, 2012;Koh et al, 1984). BMI was also shown to be associated with increased tumor thickness, which is corroborated by other recent studies (de Giorgi et al, 2013;Stenehjem et al, 2018). An explanation could be delayed presentation, which has been associated with obesity (Risica et al, 2008).…”

Section: Discussionsupporting

confidence: 87%

Environmental Exposures Such as Smoking and Low Vitamin D Are Predictive of Poor Outcome in Cutaneous Melanoma rather than Other Deprivation Measures

Hardie

Elliott

Chan

et al. 2020

Journal of Investigative Dermatology

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A lack of basic resources within a society (deprivation) is associated with increased cancer mortality, and this relationship has been described for melanoma. We have previously reported the association of smoking and low vitamin D levels with melanoma death. In this study, we further explored the associations of these with melanoma in addition to deprivation and socioeconomic stressors. In this analysis of 2,183 populationascertained primary cutaneous melanoma patients, clinical, demographic, and socioeconomic variables were assessed as predictors of tumor thickness, melanoma death and overall death. Using the Townsend deprivation score, the most deprived group did not have thicker tumors compared to the least deprived. Of the World Health Organization 25x25 risk factors for premature death, smoking and body mass index (BMI) were independently associated with thicker tumors. Low vitamin D was also independently associated with thicker tumors. No socioeconomic stressors were independent predictors of thickness. Smoking was confirmed as a key predictor of melanoma death and overall death, as were low vitamin D levels, independent of other measures of deprivation. Neither BMI nor the Townsend deprivation score were predictive in either survival analysis. We report evidence for the role of smoking, vitamin D, and BMI in melanoma progression independent of a postcode-derived measure of deprivation.

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Section: Discussionsupporting

confidence: 87%

Environmental Exposures Such as Smoking and Low Vitamin D Are Predictive of Poor Outcome in Cutaneous Melanoma rather than Other Deprivation Measures

Hardie

Elliott

Chan

et al. 2020

Journal of Investigative Dermatology

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“…We observed that 15% of the melanoma cases in this occupational cohort were diagnosed in stages T3 and T4, which is substantially lower than the 24% reported from the Janus cohort, a Norwegian population‐based study 59 . This may be explained by the mandatory frequent health examinations of offshore workers, possibly leading to early melanoma detection, 8,60 or by sex and age differences.…”

Section: Discussioncontrasting

confidence: 61%

“…Norwegian population-based study. 59 This may be explained by the mandatory frequent health examinations of offshore workers, possibly leading to early melanoma detection, 8,60 or by sex and age differences. Also, the NOPW cohort had 20% missing on Breslow thickness versus 14% in the Janus cohort, reducing comparability.…”

mentioning

confidence: 99%

Ultraviolet radiation and risk of cutaneous melanoma and squamous cell carcinoma in males and females in the Norwegian Offshore Petroleum Workers cohort

Liu

Grimsrud

Veierød

et al. 2021

American J Industrial Med

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Background Increased risk of cutaneous melanoma and squamous cell carcinoma (SCC) has been reported among petroleum workers, but few studies include females, exposure data on ultraviolet radiation (UVR), and potential confounding factors. We aimed to examine UVR exposure in relation to risk of melanoma and SCC among male and female offshore petroleum workers. We also examined the association between UVR exposure and melanoma (Breslow) thickness. Methods The Norwegian Offshore Petroleum Workers (NOPW) cohort (n = 27,917) holds information on sunbathing, indoor tanning, sunburns, sunscreen use, and other lifestyle factors recorded in 1998. Linkage to the Cancer Registry of Norway gave information on cancer diagnosis through 2017. We used Cox and logistic regression to estimate hazard ratios (HRs) of skin cancer and odds ratios (OR) of thick (≥1 mm) melanomas, respectively, with 95% confidence intervals (CIs). Results Melanoma risk increased with increasing frequency of sunbathing after age 20 (ptrend = 0.031), sunburn average intensity (ptrend = 0.028), and sunscreen use (HR = 2.16; 95% CI: 1.42 ‐3.27 for almost always vs. never/rarely). The risk of thick melanoma was inversely associated with sunbathing frequency after age 20 (OR = 0.38; 95% CI: 0.16 ‐ 0.90 for ≥4 weeks/year vs. 1 week/year). SCC risk increased with increasing frequency of indoor tanning after age 20 (HR = 2.72; 95% CI: 1.22 ‐ 6.05 for ≥3 times/months vs. never), sunburn average intensity (ptrend < 0.001), and sunscreen use (ptrend < 0.001). Conclusions Our results support associations between UVR exposure and skin cancer risk in male and female offshore petroleum workers. This occupational group may be especially relevant for targeted sun protection advice.

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“…Indeed, adjustment for sunlight exposure (Shors et al, 2001;Gallus et al, 2006) or use of hormone replacement therapy and menopausal status (Reeves et al, 2007) reveal positive associations between melanoma risk and obesity in women. On the other hand, the association between obesity and melanoma aggressiveness has been demonstrated in epidemiological studies in both men and women (de Giorgi et al, 2013;Skowron et al, 2015;Stenehjem et al, 2018) and in murine models (Pandey et al, 2012;Jung et al, 2015;Malvi et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, although controverted at first (Sergentanis et al, 2013), now, most epidemiological studies indicate that obesity increases the risk of developing melanoma, at least in men (Renehan et al, 2008;Dobbins et al, 2013). On the other hand, the association between obesity and melanoma aggressiveness has been demonstrated in epidemiological studies in both men and women (de Giorgi et al, 2013;Skowron et al, 2015;Stenehjem et al, 2018) and in murine models (Pandey et al, 2012;Jung et al, 2015;Malvi et al, 2016). Indeed, adjustment for sunlight exposure (Shors et al, 2001;Gallus et al, 2006) or use of hormone replacement therapy and menopausal status (Reeves et al, 2007) reveal positive associations between melanoma risk and obesity in women.…”

Section: Introductionmentioning

confidence: 99%

Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells

et al. 2020

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Extracellular vesicles are emerging key actors in adipocyte communication. Notably, small extracellular vesicles shed by adipocytes stimulate fatty acid oxidation and migration in melanoma cells and these effects are enhanced in obesity. However, the vesicular actors and cellular processes involved remain largely unknown. Here, we elucidate the mechanisms linking adipocyte extracellular vesicles to metabolic remodeling and cell migration. We show that adipocyte vesicles stimulate melanoma fatty acid oxidation by providing both enzymes and substrates. In obesity, the heightened effect of extracellular vesicles depends on increased transport of fatty acids, not fatty acid oxidation-related enzymes. These fatty acids, stored within lipid droplets in cancer cells, drive fatty acid oxidation upon being released by lipophagy. This increase in mitochondrial activity redistributes mitochondria to membrane protrusions of migrating cells, which is necessary to increase cell migration in the presence of adipocyte vesicles. Our results provide key insights into the role of extracellular vesicles in the metabolic cooperation that takes place between adipocytes and tumors with particular relevance to obesity.

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Anthropometric factors and Breslow thickness: prospective data on 2570 cases of cutaneous melanoma in the population-based Janus Cohort

Abstract: This large case-series of incident CM demonstrated positive associations between BMI, BSA, weight and Breslow thickness, and suggested that behavioural or other mechanisms apply at high values.

Cited by 19 publications

References 50 publications

Environmental Exposures Such as Smoking and Low Vitamin D Are Predictive of Poor Outcome in Cutaneous Melanoma rather than Other Deprivation Measures

Environmental Exposures Such as Smoking and Low Vitamin D Are Predictive of Poor Outcome in Cutaneous Melanoma rather than Other Deprivation Measures

Ultraviolet radiation and risk of cutaneous melanoma and squamous cell carcinoma in males and females in the Norwegian Offshore Petroleum Workers cohort

Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells

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