Anthropometric measures and breast cancer risk among Hispanic women in Puerto Rico

Ramírez-Marrero, Farah A.; Nazario, Cruz M.; Rosario-Rosado, Rosa V.; Schelske‐Santos, Michelle; Mansilla-Rivera, Imar; Nie, Jing; Hernández-Santiago, Johan; Freudenheim, Jo L.

doi:10.1007/s10552-022-01585-8

Cited by 4 publications

(2 citation statements)

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“…Our findings also differ from the positive association of ABSI with breast cancer overall reported by Parra-Soto et al [ 10 ] for UK Biobank, possibly due to differences in the definition of incident cancers and the influence of breast cancers diagnosed subsequently to cancers in other locations (which in our studies, the current and [ 4 ], were censored at the date of diagnosis of the first incident cancer outside the breast), or due to the inclusion of other ethnicities in their study. Although an inverse association of ABSI has been reported for post-menopausal breast cancer, specifically in HRT users [ 11 ], this population-based case-control study recruited cases within one year after cancer diagnosis and treatment, which may have influenced the results due to reverse causation. To our knowledge, no studies have previously examined associations of HI with breast cancer risk, except our UK Biobank study [ 4 ], which similarly to this study, found no evidence for association with breast cancer risk.…”

Section: Discussionmentioning

confidence: 99%

“…This was unexpected, because glucose and glycated haemoglobin were associated positively with both ABSI and BMI and inversely with HI in UK Biobank [ 8 ], and insulin resistance has been associated with breast cancer risk [ 9 ]. Therefore, a positive association of ABSI with post-menopausal breast cancer risk would be expected and has been reported for breast cancer overall by a different group using UK Biobank data [ 10 ], while an inverse association of ABSI with post-menopausal breast cancer has been reported in a case-control study [ 11 ], highlighting inconsistencies between studies. Furthermore, oestrogens, which contribute to breast cancer development [ 12 ], are generated in subcutaneous adipose tissue via aromatisation from androgens, with regional differences in aromatase expression and highest levels in the gluteofemoral region [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

et al. 2023

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Background Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI). Methods We evaluated body shape with the allometric “a body shape index” (ABSI) and hip index (HI), which compare waist and hip circumferences, correspondingly, among individuals with the same weight and height. We examined associations of ABSI, HI, and BMI (per one standard deviation increment) with breast cancer overall, and according to menopausal status at baseline, age at diagnosis, and oestrogen and progesterone receptor status (ER+/-PR+/-) in multivariable Cox proportional hazards models using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Results During a mean follow-up of 14.0 years, 9011 incident breast cancers were diagnosed among 218,276 women. Although there was little evidence for association of ABSI with breast cancer overall (hazard ratio HR = 0.984; 95% confidence interval: 0.961–1.007), we found borderline inverse associations for post-menopausal women (HR = 0.971; 0.942-1.000; n = 5268 cases) and breast cancers diagnosed at age ≥ 55 years (HR = 0.976; 0.951–1.002; n = 7043) and clear inverse associations for ER + PR- subtypes (HR = 0.894; 0.822–0.971; n = 726) and ER-PR- subtypes (HR = 0.906; 0.835–0.983 n = 759). There were no material associations with HI. BMI was associated strongly positively with breast cancer overall (HR = 1.074; 1.049–1.098), for post-menopausal women (HR = 1.117; 1.085–1.150), for cancers diagnosed at age ≥ 55 years (HR = 1.104; 1.076–1.132), and for ER + PR + subtypes (HR = 1.122; 1.080–1.165; n = 3101), but not for PR- subtypes. Conclusions In the EPIC cohort, abdominal obesity evaluated with ABSI was not associated with breast cancer risk overall but was associated inversely with the risk of post-menopausal PR- breast cancer. Our findings require validation in other cohorts and with a larger number of PR- breast cancer cases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

et al. 2023

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Metabolic syndrome as independent risk factor among sample of Egyptian women with breast cancer

et al. 2022

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Background Metabolic syndrome (MetS) and breast cancer (BC) are closely related and need more clarification. In clinical practice, the early diagnosis of BC is the most crucial issue. The current study aimed to investigate the incidence of metabolic syndrome among Egyptian women with breast cancer as independent risk factor, and the relationships between anthropometric indices (BMI, waist, hip, middle upper arm circumferences) and breast cancer risk. Results MetS rate was significantly higher among women with breast cancer (n = 89, 65%) women; compared to CG: 43.5%, (37) women therefore metabolic syndrome was strongly associated with breast cancer. More than half of BC cases (n = 85, 62%) were obese (BMI > 29.9), and 37 women (27%) were overweight (BMI 25–29.9). Additionally, the BC group had greater levels of fasting blood sugar than the control group (109.72 ± 51.31, 78.49 ± 22.79 mg/dL, respectively). Waist circumference, hip circumference, and WHtR values in BC women showed highly significant difference (p value = 0.000) compared to control group. Conclusion In our study, the metabolic syndrome and its elements were significantly correlated among Egyptian women with breast cancer. Anthropometric indices were linked to an increased risk of breast cancer.

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The relationship between central obesity and risk of breast cancer: a dose–response meta-analysis of 7,989,315 women

Chen,

Yuan,

Quan

et al. 2023

Front. Nutr.

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PurposeCentral obesity may contribute to breast cancer (BC); however, there is no dose–response relationship. This meta-analysis examined the effects of central obesity on BC and their potential dose–response relationship.MethodsIn the present study, PubMed, Medline, Embase, and Web of Science were searched on 1 August 2022 for published articles. We included the prospective cohort and case–control studies that reported the relationship between central obesity and BC. Summary effect size estimates were expressed as risk ratios (RRs) or odds ratios (ORs) with 95% confidence intervals (95% CI) and were evaluated using random-effect models. The inconsistency index (I2) was used to quantify the heterogeneity magnitude derived from the random-effects Mantel–Haenszel model.ResultsThis meta-analysis included 57 studies (26 case–control and 31 prospective cohort) as of August 2022. Case–control studies indicated that waist circumference (WC) (adjusted OR = 1.18; 95% CI: 1.00–1.38; P = 0.051) and waist-to-hip ratio (WHR) (adjusted OR = 1.28; 95% CI: 1.07–1.53; P = 0.008) were significantly positively related to BC. Subgroup analysis showed that central obesity measured by WC increased the premenopausal (adjusted OR = 1.15; 95% CI: 0.99–1.34; P = 0.063) and postmenopausal (adjusted OR = 1.18; 95% CI: 1.03–1.36; P = 0.018) BC risk and the same relationship appeared in WHR between premenopausal (adjusted OR = 1.38; 95% CI: 1.19–1.59; P < 0.001) and postmenopausal (adjusted OR = 1.41; 95% CI: 1.22–1.64; P < 0.001). The same relationship was observed in hormone receptor-positive (HR+) (adjusted ORWC = 1.26; 95% CI: 1.02–1.57; P = 0.035, adjusted ORWHR = 1.41; 95% CI: 1.00–1.98; P = 0.051) and hormone receptor-negative (HR–) (adjusted ORWC = 1.44; 95% CI: 1.13–1.83; P = 0.003, adjusted ORWHR = 1.42; 95% CI: 0.95–2.13; P = 0.087) BCs. Prospective cohort studies indicated that high WC (adjusted RR = 1.12; 95% CI: 1.08–1.16; P < 0.001) and WHR (adjusted RR = 1.05; 95% CI: 1.018–1.09; P = 0.017) may increase BC risk. Subgroup analysis demonstrated a significant correlation during premenopausal (adjusted RR = 1.08; 95% CI: 1.02–1.14; P = 0.007) and postmenopausal (adjusted RR = 1.14; 95% CI: 1.10–1.19; P < 0.001) between BC and central obesity measured by WC, and WHR was significantly positively related to BC both premenopausal (adjusted RRpre = 1.04; 95% CI: 0.98–1.11; P = 0.169) and postmenopausal (adjusted RRpost = 1.04; 95% CI: 1.02–1.07; P = 0.002). Regarding molecular subtype, central obesity was significantly associated with HR+ (adjusted ORWC = 1.13; 95% CI: 1.07–1.19; P < 0.001, adjusted ORWHR = 1.03; 95% CI: 0.98–1.07; P = 0.244) and HR– BCs (adjusted ORWC =1.11; 95% CI: 0.99–1.24; P = 0.086, adjusted ORWHR =1.01; 95% CI: 0.91–1.13; P = 0.808). Our dose–response analysis revealed a J-shaped trend in the relationship between central obesity and BC (measured by WC and WHR) in case–control studies and an inverted J-shaped trend between BMI (during premenopausal) and BC in the prospective cohort.ConclusionCentral obesity is a risk factor for premenopausal and postmenopausal BC, and WC and WHR may predict it. Regarding the BC subtype, central obesity is proven to be a risk of ER+ and ER- BCs. The dose–response analysis revealed that when BMI (during premenopausal) exceeded 23.40 kg/m2, the risk of BC began to decrease, and WC higher than 83.80 cm or WHR exceeded 0.78 could efficiently increase the BC risk.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022365788.

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Anthropometric measures and breast cancer risk among Hispanic women in Puerto Rico

Cited by 4 publications

References 46 publications

A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

Metabolic syndrome as independent risk factor among sample of Egyptian women with breast cancer

The relationship between central obesity and risk of breast cancer: a dose–response meta-analysis of 7,989,315 women

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