Anthropometric measures and the risk of developing atrial fibrillation: a Swedish Cohort Study

Zia, Isac; Johnson, Linda; Memarian, Ensieh; Borné, Yan; Engström, Gunnar

doi:10.1186/s12872-021-02415-6

Cited by 8 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although a growing body of literature has shown that obesity was strongly associated with development of AF [2][3][4][5][6][7][8][9], most previous studies were based on single time point assessment of BMI and mainly focused on Caucasian. For example, a meta-analysis of 29 prospective studies suggested that general obesity and higher BMI increased the risk of AF [3].…”

Section: Discussionmentioning

confidence: 99%

“…Atrial fibrillation (AF), the most commonly sustained arrhythmia in the general population, is a severe/growing public health issue afflicting millions of people worldwide [1]. It is well-established that overweight or obesity is strongly associated with an increased risk of incident AF [2][3][4][5][6][7][8][9]. However, the consensus regarding the patterns of association between body mass index (BMI) and AF risk is still lacking.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation

Zhao,

Song,

Zhao

et al. 2022

BMC Med

View full text Add to dashboard Cite

Background Although obesity has been associated with risk of atrial fibrillation (AF), the associations of variability of obesity measures with AF risk are uncertain, and longitudinal studies among Chinese population are still lacking. We aimed to evaluate the impacts of obesity and variability of body mass index (BMI) and waist circumference (WC) on the risk of atrial fibrillation (AF) in a large Chinese cohort study. Methods A total of 44,135 participants of the Kailuan Study who were free of cancer and cardiovascular disease and underwent three consecutive surveys from 2006 to 2010 were followed for incident AF until 2020. Average BMI and WC over time and variability were calculated. Cox proportional hazards regression models were used to assess hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of obesity and variability in BMI and WC with AF risk. Results During a mean follow-up of 9.68 years, there were 410 cases of incident AF. In multivariable-adjusted models, compared with normal BMI/WC, individuals with general obesity and abdominal obesity had increased risk of AF, with corresponding HRs of 1.73 (95% CI: 1.31–2.30) and 1.38 (95% CI: 1.11–1.60), respectively. The short-term elevation in AF risk persisted for the obese even after adjustment for updated biologic intermediaries and weight. Variability in BMI and WC were not associated with the risk of AF. The restricted cubic spline models indicated significant linear relationships between levels of WC and BMI and risk of AF. Conclusions Elevated levels of BMI and WC were associated with an increased risk of AF, whereas variability in BMI and WC were not. Therefore, achieving optimal levels of BMI and WC could be valuable in AF prevention.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation

Zhao,

Song,

Zhao

et al. 2022

BMC Med

View full text Add to dashboard Cite

show abstract

“…Although the association between these anthropometric traits and ECG indices of atrial conduction has not been described previously, studies have reported a stronger contribution of lean body mass on excess AF risk conferred by BMI [49][50][51][52] compared to fat mass. Similarly, height has been associated with greater risk of AF in observational and MR studies [53][54][55][56][57][58][59][60][61]. Although the mechanisms underlying these associations are unclear, a possible explanation relates to left atrial volume.…”

Section: Plos Medicinementioning

confidence: 99%

Multiple anthropometric measures and proarrhythmic 12-lead ECG indices: A mendelian randomization study

et al. 2023

View full text Add to dashboard Cite

Background Observational studies suggest that electrocardiogram (ECG) indices might be influenced by obesity and other anthropometric measures, though it is difficult to infer causal relationships based on observational data due to risk of residual confounding. We utilized mendelian randomization (MR) to explore causal relevance of multiple anthropometric measures on P-wave duration (PWD), PR interval, QRS duration, and corrected QT interval (QTc). Methods and findings Uncorrelated (r2 < 0.001) genome-wide significant (p < 5 × 10−8) single nucleotide polymorphisms (SNPs) were extracted from genome-wide association studies (GWAS) on body mass index (BMI, n = 806,834), waist:hip ratio adjusted for BMI (aWHR, n = 697,734), height (n = 709,594), weight (n = 360,116), fat mass (n = 354,224), and fat-free mass (n = 354,808). Genetic association estimates for the outcomes were extracted from GWAS on PR interval and QRS duration (n = 180,574), PWD (n = 44,456), and QTc (n = 84,630). Data source GWAS studies were performed between 2018 and 2022 in predominantly European ancestry individuals. Inverse-variance weighted MR was used for primary analysis; weighted median MR and MR-Egger were used as sensitivity analyses. Higher genetically predicted BMI was associated with longer PWD (β 5.58; 95%CI [3.66,7.50]; p = < 0.001), as was higher fat mass (β 6.62; 95%CI [4.63,8.62]; p < 0.001), fat-free mass (β 9.16; 95%CI [6.85,11.47]; p < 0.001) height (β 4.23; 95%CI [3.16, 5.31]; p < 0.001), and weight (β 8.08; 95%CI [6.19,9.96]; p < 0.001). Finally, genetically predicted BMI was associated with longer QTc (β 3.53; 95%CI [2.63,4.43]; p < 0.001), driven by both fat mass (β 3.65; 95%CI [2.73,4.57]; p < 0.001) and fat-free mass (β 2.08; 95%CI [0.85,3.31]; p = 0.001). Additionally, genetically predicted height (β 0.98; 95%CI [0.46,1.50]; p < 0.001), weight (β 3.45; 95%CI [2.54,4.36]; p < 0.001), and aWHR (β 1.92; 95%CI [0.87,2.97]; p = < 0.001) were all associated with longer QTc. The key limitation is that due to insufficient power, we were not able to explore whether a single anthropometric measure is the primary driver of the associations observed. Conclusions The results of this study support a causal role of BMI on multiple ECG indices that have previously been associated with atrial and ventricular arrhythmic risk. Importantly, the results identify a role of both fat mass, fat-free mass, and height in this association.

show abstract

Obesity effect on newly diagnosed and recurrent post-ablation atrial fibrillation: a systematic review and meta-analysis

Folli,

Centofanti,

Magnani

et al. 2023

J Endocrinol Invest

View full text Add to dashboard Cite

Anthropometric measures and the risk of developing atrial fibrillation: a Swedish Cohort Study

Cited by 8 publications

References 36 publications

Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation

Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation

Multiple anthropometric measures and proarrhythmic 12-lead ECG indices: A mendelian randomization study

Obesity effect on newly diagnosed and recurrent post-ablation atrial fibrillation: a systematic review and meta-analysis

Contact Info

Product

Resources

About