Anthropomorphic Polydimethylsiloxane silicone-based phantom for Diffuse Optical Imaging

Serra, María Victoria Waks; Grau, V. Noseda; Vera, Demián Augusto; Jodra, S.; García, Héctor; Carbone, Nicolás; Pardini, P.A.; Pomarico, Juan A.; Iriarte, D.

doi:10.1016/j.heliyon.2022.e10308

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…Images are normalized to the background intensity to emphasize the difference between homogeneous tissue (the background) and any inhomogeneity that may be present. We tested this through numerical Monte Carlo (MC) simulations and phantoms that simulate biological tissues (Serra et al 2022). We further studied detectability limits and the potential to obtain 3D information of the position and characteristics of the inclusion; results indicated (i) detection of absorption variations is achieved if images are normalized to background intensity and (ii) inclusions are detected in realistic conditions of depth and absorption contrast for breast lesions (Carbone et al 2014).…”

Section: The Nir Contributionmentioning

confidence: 99%

MamoRef: an optical mammography device using whole-field CW diffuse reflectance. Presentation, validation and preliminary clinical results

Carbone,

Vera,

Victoria Waks-Serra

et al. 2023

Phys. Med. Biol.

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Objective. MamoRef is an mammography device that uses near-infrared light, designed to provide clinically relevant information for the screening of diseases of the breast. Using low power continuous wave lasers and a high sensitivity CCD (Charge-coupled device) that captures a diffusely reflected image of the tissue, MamoRef results in a versatile diagnostic tool that aims to fulfill a complementary role in the diagnosis of breast cancer providing information about the relative hemoglobin concentrations as well as oxygen saturation. Approach. We present the design and development of an initial prototype of MamoRef. To ensure its effectiveness, we conducted validation tests on both the theoretical basis of the reconstruction algorithm and the hardware design. Furthermore, we initiated a clinical feasibility study involving patients diagnosed with breast disease, thus evaluating the practical application and potential benefits of MamoRef in a real-world setting. Main results. Our study demonstrates the effectiveness of the reconstruction algorithm in recovering relative concentration differences among various chromophores, as confirmed by Monte Carlo simulations. These simulations show that the recovered data correlates well with the ground truth, with SSIMs of 0.8 or more. Additionally, the phantom experiments validate the hardware implementation. The initial clinical findings exhibit highly promising outcomes regarding MamoRef’s ability to differentiate between lesions. Significance. MamoRef aims to be an advancement in the field of breast pathology screening and diagnostics, providing complementary information to standard diagnostic techniques. One of its main advantages is the ability of determining oxy/deoxyhemoglobin concentrations and oxygen saturation; this constitutes valuable complementary information to standard diagnostic techniques. Besides, MamoRef is a portable and relatively inexpensive device, intended to be not only used in specific medical imaging facilities. Finally, its use does not require external compression of the breast. The findings of this study underscore the potential of MamoRef in fulfilling this crucial role.

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Section: The Nir Contributionmentioning

confidence: 99%

MamoRef: an optical mammography device using whole-field CW diffuse reflectance. Presentation, validation and preliminary clinical results

Carbone,

Vera,

Victoria Waks-Serra

et al. 2023

Phys. Med. Biol.

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“…The decision was made to implement the polydimethylsiloxane silicone-based phantom because it has similar mechanical and optical properties to real breast tissue. These kinds of phantoms are used to test systems that implement diffuse optical imaging with red or NIR light for biomedical image processing in breast cancer diagnosis [39]. India ink's optical properties are known to be similar to a tumor in the red and NIR irradiation range [40,41].…”

Section: Phantom Tissuementioning

confidence: 99%

Design of a Low-Cost Diffuse Optical Mammography System for Biomedical Image Processing in Breast Cancer Diagnosis

Rivera-Fernández

Roa-Tort

Stolik

et al. 2023

Sensors

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Worldwide, breast cancer is the most common type of cancer that mainly affects women. Several diagnosis techniques based on optical instrumentation and image analysis have been developed, and these are commonly used in conjunction with conventional diagnostic devices such as mammographs, ultrasound, and magnetic resonance imaging of the breast. The cost of using these instruments is increasing, and developing countries, whose deaths indices due to breast cancer are high, cannot access conventional diagnostic methods and have even less access to newer techniques. Other studies, based on the analysis of images acquired by traditional methods, require high resolutions and knowledge of the origin of the captures in order to avoid errors. For this reason, the design of a low-cost diffuse optical mammography system for biomedical image processing in breast cancer diagnosis is presented. The system combines the acquisition of breast tissue photographs, diffuse optical reflectance (as a biophotonics technique), and the processing of digital images for the study and diagnosis of breast cancer. The system was developed in the form of a medical examination table with a 638 nm red-light source, using light-emitted diode technology (LED) and a low-cost web camera for the acquisition of breast tissue images. The system is automatic, and its control, through a graphical user interface (GUI), saves costs and allows for the subsequent analysis of images using a digital image-processing algorithm. The results obtained allow for the possibility of planning in vivo measurements. In addition, the acquisition of images every 30° around the breast tissue could be used in future research in order to perform a three-dimensional (3D) reconstruction and an analysis of the captures through deep learning techniques. These could be combined with virtual, augmented, or mixed reality environments to predict the position of tumors, increase the likelihood of a correct medical diagnosis, and develop a training system for specialists. Furthermore, the system allows for the possibility to develop analysis of optical characterization for new phantom studies in breast cancer diagnosis through bioimaging techniques..

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“…Anthropomorphic optical phantoms having specific optical properties have been documented in the literature [15,16]. However, replicating optical properties and anthropomorphic features into a phantom for PDT application despite technological advancements still presents various degrees of challenges.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Heterogeneous Phantoms for Biomedical Applications: a demonstration to dosimetry validation

Ghauri,

Susnjar,

Guadagno

et al. 2023

Preprint

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Phantoms simultaneously mimicking anatomical and optical properties of real tissues can play a pivotal role for improving dosimetry algorithms. The aim of the paper is to design and develop a hybrid phantom model that builds up on the strengths of solid and liquid phantoms for mimicking various anatomical structures for prostate cancer photodynamic therapy (PDT) dosimetry validation. The model comprises of a photosensitizer-embedded gelatin lesion within a liquid intralipid prostate shape that is surrounded by a solid silicone outer shell. The hybrid phantom was well characterized for optical properties. The final assembled phantom was also evaluated for fluorescence tomographic reconstruction in conjunction with SpectraCure’s IDOSE® software. The developed model can lead to advancements in dosimetric evaluations. This would improve PDT outlook as a clinical treatment modality and boost phantom based standardization of biophotonic devices globally.

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Anthropomorphic Polydimethylsiloxane silicone-based phantom for Diffuse Optical Imaging

Cited by 6 publications

References 39 publications

MamoRef: an optical mammography device using whole-field CW diffuse reflectance. Presentation, validation and preliminary clinical results

MamoRef: an optical mammography device using whole-field CW diffuse reflectance. Presentation, validation and preliminary clinical results

Design of a Low-Cost Diffuse Optical Mammography System for Biomedical Image Processing in Breast Cancer Diagnosis

Hybrid Heterogeneous Phantoms for Biomedical Applications: a demonstration to dosimetry validation

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