Anti-acetylcholinesterase and Antioxidant Activity of Essential Oils from Hedychium gardnerianum Sheppard ex Ker-Gawl

Arruda, Miguel; Viana, Hugo; Rainha, Nuno; Neng, Nuno R.; Rosa, José S.; Nogueira, J.M.F.; Barreto, Maria Carmo

doi:10.3390/molecules17033082

Cited by 62 publications

(44 citation statements)

References 24 publications

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“…The origin of changes should be sought mainly in the differences in the nature of soil on the one hand and solar radiation on the other. Both factors involve the activation or inactivation of certain enzymatic groups, leading to the predominance of a particular biosynthetic pathway (Arruda et al, 2012). Altitudinal changes sea level is an important factor influencing terrestrial ecosystems.…”

Section: Resultsmentioning

confidence: 99%

“…Similar to the other taxa of the genus Kundmannia, K. anatolica produces essential oils, which can be extracted from different parts of the plant, including the fruit, root and flower as well as stem and leafs, with significant diversity in yield and composition. In general, the relative composition of essential oils varies remarkably with geographical position, climate conditions and several other factors (Arruda et al, 2012). There are many studies related to the essential oils in Apiaceae species.…”

Section: Introductionmentioning

confidence: 99%

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GEOGRAPHICAL IMPACT ON ESSENTIAL OIL COMPOSITION OF ENDEMICKundmanniaanatolicaHUB.-MOR.(APIACEAE)

Şanli¹,

Karadoğan²

2016

AJTCAM

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Background: Kundmannia anatolica Hub.-Mor. is an endemic specie of Apiaceae diversified in Turkey. Several parts of the plant may contain essential oils in different quantity which can be influenced by environmental factors, mainly altitude. The aim of this study was to test whether there is any altitude effect on volatile chemical constituents of essential oil obtained from the fruits of K. anatolica growing spontaneously in different altitudes of Lakes Region in Turkey. Materials and Methods: K. anatolica was collected in 2015 at different altitudes (400, 820, 1002 and 1560 m) of Lakes Region Turkey. The fruits of the plants were distilled for 3 h using a Clevenger type apparatus according to the British Pharmacopiea (1980). Essential oils of the fruits were collected using hydro distillation method and analyzed by GC-MS/FID. Results: Essential oil contents of fruits increased by corresponding increase in altitude level. Predominant compounds were α-Pinene (27.87-61.94%) and β-Pinene (24.92-36.46%) of the total oil of K. anatolica. Other important compounds were α-Thujene (2.66-8.15%), l-Limonene (1.83-8.23%), α-Phellandrene (1.85-5.01%) and these compounds were higher in low altitudes. Conclusion: Altitude change affected the terpenoid biosynthesis and oxygenated monoterpenes generally and were greatest when low; while sesquiterpene constituents were greatest at high altitudes. The influence of altitude seems to be an important factor for yielding the chemical profile of K. anatolica essential oils. Thus, the location of the plant must be taken into account depending on the intended use.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

GEOGRAPHICAL IMPACT ON ESSENTIAL OIL COMPOSITION OF ENDEMICKundmanniaanatolicaHUB.-MOR.(APIACEAE)

Şanli¹,

Karadoğan²

2016

AJTCAM

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“…Acetylcholinesterase inhibitory activity by the essential oil from Polygonum hydropiper L, Hedychium gardnerianum sheppard ex Ker‐Gawl, and Lavandula pedunculata subsp. lusitanica (Chaytor) Franco has been reported . This EORO also has an effect on Alzheimer's type dementia by acting on acetylcholine‐based neurotransmission.…”

Section: Resultsmentioning

confidence: 94%

The effect of inhalation of essential oil from Rosmarinus officinalis on scopolamine‐induced Alzheimer's type dementia model mice

Satou

Hanashima

Mizutani

et al. 2018

Flavour & Fragrance J

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Essential oil from Rosmarinus officinalis (Rosemary essential oil, EORO) may improve cognitive function by activating the central nervous system. However, no scientific basis for the effect of EORO has been described. Therefore, we investigated the effect of EORO on Alzheimer's type dementia using model mice. Mice were administered EORO by inhalation. Then, scopolamine was used to prepare Alzheimer's type dementia model mice. To evaluate cognitive function, the Y‐maze test was used for assessment of short‐term memory. EORO produced a significant improvement in the rate of spontaneous alternation behavior. Furthermore, 1,8‐cineole, α‐pinene, and β‐pinene, the main components of EORO, were detected in the brain in a concentration‐dependent manner following inhalation of EORO. Thus, inhalation of EORO may improve cognitive function in a model of Alzheimer's type dementia. Components such as 1,8‐cineole and others are likely involved in the effects on the brain. Examination of the detailed mechanism of action of EORO is necessary for future clinical application.

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“…The anti-AChE activity determination was assessed following the assay described by [12] at pH 8.0 and using acetylthiocholine iodide as substrate, in the presence of buffer containing DTNB and extract in different concentrations. The reaction was followed for 7.5 min at 415 nm, using a Bio-Rad Model 680 Microplate reader.…”

Section: Acetylcholinesterase Inhibitionmentioning

confidence: 99%

Anti-acetylcholinesterasic, antioxidant and antibacterial activities of Juniperus brevifolia extracts

Oliveira¹,

Medeiros²,

Rosa³

et al. 2015

Integr Pharm Toxicol Gentoxicol

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Juniperus brevifolia (Seub.) Antoine (Cupressaceae) is an endemic conifer of the Azores, a habitat isolated from the continental masses which may significantly influence the biosynthesis of bioactive compounds with unique features. In this context, the toxicity, antibacterial, antioxidant (DPPH) and anti-acetylcholinesterasic (anti-AChE) activities of the methanol and acetone extracts of J. brevifolia wood and bark were evaluated for the first time. In the brine-shrimp assay all the extracts showed low toxicity, with the concentration causing 50% mortality (LC 50 ) higher than 2.03 mg/mL. The acetone extract of the bark proved to be the most active against Bacillus cereus, B. subtilis and Micrococcus luteus, while the wood acetone extract showed activity only against B. cereus. No activity was observed against Gram (-) bacteria Escherichia coli and Enterobacter cloacae. The acetone extract of bark was the most active showing the higher antioxidant (EC 50 =7.0 µg/mL) and antiAChE activities (IC 50 =193 µg/mL), near to the reference compounds, quercetin (EC 50 =3.2 µg/mL) and ursolic acid (IC 50 =190 µg/mL), respectively. The present study demonstrates the great potential of the acetone bark extract of J. brevifolia as a source of new non-toxic natural bioactive compounds as antioxidant and antiacetylcholinesterasic drugs.

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Anti-acetylcholinesterase and Antioxidant Activity of Essential Oils from Hedychium gardnerianum Sheppard ex Ker-Gawl

Cited by 62 publications

References 24 publications

GEOGRAPHICAL IMPACT ON ESSENTIAL OIL COMPOSITION OF ENDEMICKundmanniaanatolicaHUB.-MOR.(APIACEAE)

GEOGRAPHICAL IMPACT ON ESSENTIAL OIL COMPOSITION OF ENDEMICKundmanniaanatolicaHUB.-MOR.(APIACEAE)

The effect of inhalation of essential oil from Rosmarinus officinalis on scopolamine‐induced Alzheimer's type dementia model mice

Anti-acetylcholinesterasic, antioxidant and antibacterial activities of Juniperus brevifolia extracts

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