Anti‐acid medication as a risk factor for food allergy

Pali‐Schöll, Isabella; Jensen‐Jarolim, Erika

doi:10.1111/j.1398-9995.2010.02511.x

Cited by 88 publications

(73 citation statements)

References 100 publications

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“…1) [42]. Secretin is essential to stimulate pancreatic secretion of the proteases trypsin, chymotrypsin, and carboxypeptidases [43]. ese proteases and peptidases are responsible for further peptide digestion into single amino acids or small peptides, which are subsequently taken up by enterocytes for nutrition of the human body.…”

Section: Impact Of Anti-ulcer Drugs On Function Of the Gastrointestinmentioning

confidence: 99%

Acid suppression therapy and allergic reactions

Untersmayr¹

2015

Allergo J

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e development of pharmaceutical agents reducing gastric acidity such as sucralfate, histamine 2 (H2) receptor blockers, and proton pump inhibitors (PPIs) has been a milestone for the treatment of dyspeptic disorders. However, due to current prescription habits resulting in overuse of these potent drugs as well as over-the-counter (OTC) availability associated with self-medication, substantial health concern is related to the mechanisms of drug action as well as known side e ects in uencing gastrointestinal physiology. More than a decade ago, the rst study appeared reporting an association between anti-ulcer drug intake and food allergy development. Since then, several experimental and human studies veri ed this correlation, demonstrating that acid suppressive drugs not only in uence the sensitization capacity of orally ingested proteins, but also represent a risk factor for food allergic patients. Additionally, gastric acid suppression was reported to increase the risk for development of drug hypersensitivity reactions. ese consequences of anti-ulcer drug intake might on the one hand be associated with direct in uence of these drugs on immune responses. On the other hand reduction of gastric acidity leads to impaired gastrointestinal protein degradation. Nevertheless, also disruption of the gastrointestinal barrier function, changes in microbiome, or lack of tolerogenic peptic digests might contribute to the connection between anti-ulcer drug intake and allergic reaction. erefore, these drugs should only be prescribed based on a precise gastroenterological diagnosis taking into consideration allergological mechanisms to ensure patients' safety.Cite this as: Untersmayr E. Acid suppression therapy and allergic reactions.

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Section: Impact Of Anti-ulcer Drugs On Function Of the Gastrointestinmentioning

confidence: 99%

Acid suppression therapy and allergic reactions

Untersmayr¹

2015

Allergo J

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“…Leki te poprzez wiązanie się z grupami cystynowymi H+/K+ ATP-azy komórek okładzino-wych żołądka hamują produkcję kwasu solnego, tym samym zwiększając pH treści żołądkowej. Dzięki temu efektowi możliwa jest profilaktyka dalszego uszkadzania błony śluzowej przez kwas solny oraz zapewnienie warunków do wygojenia się błony śluzowej żołądka [1,2]. IPP uważane są za leki wysoce selektywne, skuteczne, mające również niewiele działań niepożądanych [1,3,4].…”

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“…Optymalna kwasowość soku żołądkowego, w której występuje pełna aktywność pepsyny, to 1,8-3,2. Im wyższe jest pH soku żołądkowego, tym niższa jest aktywność pepsyny [2]. Już przyjmowanie IPP przez 5 dni podwyższa pH soku żołądkowego do około 5,0.…”

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“…Ponadto przechodząca do dwunastnicy treść żołądkowa, ze względu na podwyższone pH, nie stymuluje wydzielania sekretyny, co prowadzi do niewystarczającej stymulacji proteaz trzustkowych. Przetrwałe peptydy pozostają immunoreaktywne i prowadzą do rozwoju odpowiedzi alergicznej [2,10]. Drugim mechanizmem odpowiedzialnym za indukcję odpowiedzi alergicznej IPP jest zwiększenie przepuszczalności błony śluzowej przewodu pokarmowego, ułatwiające absorbcję alergenów [11,12].…”

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Ocena zależności między stosowaniem inhibitorów pompy protonowej a występowaniem uczulenia na wybrane alergeny pokarmowe

Mielniczuk

Czerwionka-Szaflarska

2014

Pediatria Polska

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“…One hypothesis that has been considered is the increasing use of proton pump inhibitors (PPIs) for digestive disorders [7]. This therapeutic class was introduced in 1988 and today they are among the most used drugs worldwide, including Brazil.…”

Section: Introductionmentioning

confidence: 99%

The Assessment of the Arising of Food Allergy among Antiacid Users Using Mathematical Model

Yang

Yang²,

Santos³

et al. 2012

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The first case of a new food allergy, an anaphylactic reaction to Manioc (Manihot esculenta or Manihot utilissima), also called cassava and tapioca, was described in 2001. Cassava is a tuber widely consumed in Brazil, which has been consumed by native Indians, i.e., more than 500 years ago, so why are the first cases just emerging now? We address this question by developing a mathematical model considering the fact that proton pump inhibitors (PPIs) for digestive disorders maintain the cassava allergen intact due to the elevation in pH of gastric juice, thereby facilitating its presentation to the immune system. The model assumed the mass action law including saturation to describe the recruitment of PPIs users, and Hill function to describe the sensitization of immune system by the allergens and the acquisition of full food allergy. Analytical results were obtained from the model, and numerical simulations were done. The estimated period of time elapsed since the introduction of antiacids before the diagnosis of food allergy was 15 years. The food allergy may become a public health problem, if PPIs are being used indiscriminately and irregularly. The results obtained from the analysis of the model suggest that the use of nonprescription antiacids, like PPIs, may be recommended or approved by the physician in order to avoid the rising of food allergy.

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Anti‐acid medication as a risk factor for food allergy

Cited by 88 publications

References 100 publications

Acid suppression therapy and allergic reactions

Acid suppression therapy and allergic reactions

Ocena zależności między stosowaniem inhibitorów pompy protonowej a występowaniem uczulenia na wybrane alergeny pokarmowe

The Assessment of the Arising of Food Allergy among Antiacid Users Using Mathematical Model

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