Anti-ageing gene therapy: Not so far away?

Vaiserman, Alexander; Falco, Elena De; Koliada, Alexander; Maslova, O.O.; Balistreri, Carmela Rita

doi:10.1016/j.arr.2019.100977

Cited by 24 publications

(22 citation statements)

References 135 publications

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“…Lifespan is a biological characteristic of every species. However, it can be modified by mutations or by a variety of interventions (e.g., lifestyle, pharmacological, stem cell, and genetic interventions) [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Aging and Lifespanmentioning

confidence: 99%

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The Centenarians: An Emerging Population

Heshmati¹

2021

Update in Geriatrics

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Long life is a topic of great interest in medicine and among the general public. The “successful aging” which is a high priority for individuals and societies, is aging without any disabilities and severe diseases. In several countries, the increase in life expectancy has led the very old to become the fastest growing segment of the population. Centenarians are subjects living 100 years or older. The majority of centenarians are females (female to male ratio around 3.6/1). A very small fraction of centenarians (up to 0.5%) will live 110 years or older (supercentenarians). Most centenarians have managed to avoid, postpone, or overcome the important age-related and life-threatening diseases and disabilities (e.g., ischemic heart disease, stroke, chronic obstructive pulmonary disease, cancer, respiratory infection, type 2 diabetes, osteoporosis, and dementia). Some forecasts suggest that most babies born in developed countries since 2000 will become centenarians. In 2020, the number of centenarians in the world was approximately 573,000, mainly from the United States of America (USA). This number could reach approximately 3,676,000 by 2050. In the absence of the genetic predisposition to become centenarian, there are several ways to extend longevity (e.g., lifestyle, reduction of several life-threatening diseases and disabilities, hormonal replacement or blockade, antioxidants, maintenance of a proper autophagic activity, stem cell therapy, and gene therapy). The continuous increase of the number of centenarians has worldwide practical implications including profound impact on intergenerational interactions and significant financial challenges for any society, especially in relation to medical expenses.

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Section: Aging and Lifespanmentioning

confidence: 99%

“…Genes are promising research targets to delay the aging process and extend longevity (Figure 15) [24]. Gene therapy allows the modulation of the genome architecture using both direct (by gene editing) and indirect (by viral or non-viral vectors) approaches.…”

Section: Gene Therapymentioning

confidence: 99%

The Centenarians: An Emerging Population

Heshmati¹

2021

Update in Geriatrics

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“…More recently, aging has been reviewed and re-defined (Holliday, 2006;Hayflick, 2007;Flatt, 2012;Rose et al, 2012;Kennedy et al, 2014;Gladyshev, 2016) with further and significant considerations toward positive aspects of aging, the heterogeneity of aging, and the feasibility of understanding and reversing the aging process. Additionally, much work has been done to establish and review the biochemical and cellular mechanisms of aging (Rattan, 2009;Salminen and Kaarniranta, 2009;Kenyon, 2010;van Deursen, 2014;Childs et al, 2015;Longo et al, 2015;Kauppila et al, 2017;Herranz and Gil, 2018) as well as potential pharmacological therapeutic options (Kaeberlein et al, 2015;Shetty et al, 2018;Fuellen et al, 2019;Vaiserman et al, 2019;Hodgson et al, 2020). We encourage interested readers to explore these reviews and others for more contextual understanding of aging.…”

Section: Lifespan Healthspan and Agingmentioning

confidence: 99%

Improvements to Healthspan Through Environmental Enrichment and Lifestyle Interventions: Where Are We Now?

2020

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Environmental enrichment (EE) is an experimental paradigm that is used to explore how a complex, stimulating environment can impact overall health. In laboratory animal experiments, EE housing conditions typically include larger-than-standard cages, abundant bedding, running wheels, mazes, toys, and shelters which are rearranged regularly to further increase stimulation. EE has been shown to improve multiple aspects of health, including but not limited to metabolism, learning and cognition, anxiety and depression, and immunocompetence. Recent advances in lifespan have led some researchers to consider aging as a risk factor for disease. As such, there is a pressing need to understand the processes by which healthspan can be increased. The natural and predictable changes during aging can be reversed or decreased through EE and its underlying mechanisms. Here, we review the use of EE in laboratory animals to understand mechanisms involved in aging, and comment on relative areas of strength and weakness in the current literature. We additionally address current efforts toward applying EE-like lifestyle interventions to human health to extend healthspan. Although increasing lifespan is a clear goal of medical research, improving the quality of this added time also deserves significant attention. Despite hurdles in translating experimental results toward clinical application, we argue there is great potential in using features of EE toward improving human healthy life expectancy or healthspan, especially in the context of increased global longevity.

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“…These success stories have led to the formulation of the geroscience hypothesis: interventions that slow down aging will simultaneously prevent, delay and/or reduce the severity of many age-related diseases [ 16 , 26 , 27 ]. As dietary interventions prove to be challenging for most people to adhere to in the long term [ 28 , 29 ] and genetic interventions still suffer from many technical, ethical and safety problems [ 30 , 31 ], the main potential in the near future for human clinical translation is the development of pharmacological interventions in the aging process: so-called geroprotective drugs [ 22 , 32 , 33 , 34 ]. Multiple drugs such as rapamycin, metformin, spermidine, senolytics, lithium and acarbose have been found to extend lifespan in model organisms [ 21 , 22 , 32 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Phenotypic Screening in C. elegans as a Tool for the Discovery of New Geroprotective Drugs

Bulterijs

Braeckman

2020

Pharmaceuticals

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Population aging is one of the largest challenges of the 21st century. As more people live to advanced ages, the prevalence of age-related diseases and disabilities will increase placing an ever larger burden on our healthcare system. A potential solution to this conundrum is to develop treatments that prevent, delay or reduce the severity of age-related diseases by decreasing the rate of the aging process. This ambition has been accomplished in model organisms through dietary, genetic and pharmacological interventions. The pharmacological approaches hold the greatest opportunity for successful translation to the clinic. The discovery of such pharmacological interventions in aging requires high-throughput screening strategies. However, the majority of screens performed for geroprotective drugs in C. elegans so far are rather low throughput. Therefore, the development of high-throughput screening strategies is of utmost importance.

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Anti-ageing gene therapy: Not so far away?

Cited by 24 publications

References 135 publications

The Centenarians: An Emerging Population

The Centenarians: An Emerging Population

Improvements to Healthspan Through Environmental Enrichment and Lifestyle Interventions: Where Are We Now?

Phenotypic Screening in C. elegans as a Tool for the Discovery of New Geroprotective Drugs

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