Anti-aging activities of Rehmannia glutinosa Libosch. crude polysaccharide in Caenorhabditis elegans based on gut microbiota and metabonomic analysis

Liang, Lanyuan; Yue, Yimin; Zhong, Luyang; Liang, Yefang; Shi, Ruixiang; Luo, Rongfeng; Zhao, Mantong; Cao, Xia; Yang, Mengru; Du, Jieyong; Shen, Xuejuan; Wang, Yi; Shu, Zunpeng

doi:10.1016/j.ijbiomac.2023.127647

Cited by 9 publications

(1 citation statement)

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“…The abundance of Lachnospiraceae is involved in ageing and the regulation of inflammation. It has been found that Rehmannia glutinosa polysaccharides can enhance the antioxidant enzyme system and delay ageing in Caenorhabditis elegans , which may be associated with increased abundance of Lachnospiraceae NK4B4 group and regulation of amino acid metabolism and energy cycling [ 41 ]. FMT from young mice rejuvenates the aged hematopoietic stem cells and mitigates inflammatory signals by increasing Lachnospiraceae and tryptophan-associated metabolites [ 42 ].…”

Section: Roles Of the Gut Microbiome In Ndsmentioning

confidence: 99%

Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

Ma,

Li,

et al. 2024

Transl Neurodegener

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The aetiologies and origins of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD), are complex and multifaceted. A growing body of evidence suggests that the gut microbiome plays crucial roles in the development and progression of neurodegenerative diseases. Clinicians have come to realize that therapeutics targeting the gut microbiome have the potential to halt the progression of neurodegenerative diseases. This narrative review examines the alterations in the gut microbiome in AD, PD, ALS and HD, highlighting the close relationship between the gut microbiome and the brain in neurodegenerative diseases. Processes that mediate the gut microbiome–brain communication in neurodegenerative diseases, including the immunological, vagus nerve and circulatory pathways, are evaluated. Furthermore, we summarize potential therapeutics for neurodegenerative diseases that modify the gut microbiome and its metabolites, including diets, probiotics and prebiotics, microbial metabolites, antibacterials and faecal microbiome transplantation. Finally, current challenges and future directions are discussed.

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Section: Roles Of the Gut Microbiome In Ndsmentioning

confidence: 99%