Anti-aging and anti-microbial effects of melleolide on various types of yeast

Nakaya, Shigeru; Kobori, Hajime; Sekiya, Atsushi; Kawagishi, Hirokazu; Ushimaru, Takashi

doi:10.1080/09168451.2014.885826

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…In the literature, only few compounds were reported as having the ability to increase the reproductive potential of yeast, such as resveratrol (Howitz et al 2003 ), ascorbate (Krzepilko et al 2004 ), diazaborine (Steffen et al 2008 ) and ibuprofen (He et al 2014 ). More information can be found regarding the effects of various factors on prolonging the chronological lifespan of yeast (Georgieva et al 2015 ; Nakaya et al 2014 ; Rockenfeller et al 2015 ; Wanke et al 2008 ; Wu et al 2014 ). However, one should not compare these two types of experiments since the chronological lifespan and the total lifespan are not the same.…”

Section: Discussionmentioning

confidence: 99%

l-carnosine enhanced reproductive potential of the Saccharomyces cerevisiae yeast growing on medium containing glucose as a source of carbon

et al. 2016

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Carnosine is an endogenous dipeptide composed of β-alanine and l-histidine, which occurs in vertebrates, including humans. It has a number of favorable properties including buffering, chelating, antioxidant, anti-glycation and anti-aging activities. In our study we used the Saccharomyces cerevisiae yeast as a model organism to examine the impact of l-carnosine on the cell lifespan. We demonstrated that l-carnosine slowed down the growth and decreased the metabolic activity of cells as well as prolonged their generation time. On the other hand, it allowed for enhancement of the yeast reproductive potential and extended its reproductive lifespan. These changes may be a result of the reduced mitochondrial membrane potential and decreased ATP content in the yeast cells. However, due to reduction of the post-reproductive lifespan, l-carnosine did not have an influence on the total lifespan of yeast. In conclusion, l-carnosine does not extend the total lifespan of S. cerevisiae but rather it increases the yeast’s reproductive capacity by increasing the number of daughter cells produced.

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Section: Discussionmentioning

confidence: 99%

l-carnosine enhanced reproductive potential of the Saccharomyces cerevisiae yeast growing on medium containing glucose as a source of carbon

et al. 2016

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“…Cell membrane would be the first assaulting target of ethanol (Ma et al 2013), and increasing ethanol can also result in variation of the structure and fluidity of the cell plasma membrane (Li et al 2014), even induce degradation of proteins (Ding et al 2009b). Furthermore, the normal aging of cells may also cause aggravation of oxidization and degradation of proteins (Nakaya et al 2014). Therefore, to survive under the increased ethanol stress, a series of cell physiological changes might occur in S. cerevisiae cells to stabilize the structure of membrane and proteins (Tibayrenc et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Changes of trehalose content and expression of relative genes during the bioethanol fermentation bySaccharomyces cerevisiae

Wang

Dong

et al. 2016

Can. J. Microbiol.

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Traditionally, trehalose is considered as a protectant to improve the ethanol tolerance of Saccharomyces cerevisiae. In this study, to clarify the changes and roles of trehalose during the bioethanol fermentation, trehalose content and expression of related genes at lag, exponential, and stationary phases (i.e., 2, 8, and 16 h of batch fermentation process) were determined. Although yeast cells at exponential and stationary phase had higher trehalose content than cells at lag phase (P < 0.01), there was no significant difference in trehalose content between exponential and stationary phases (P > 0.05). Moreover, expression of the trehalose degradation-related genes NTH1 and NTH2 decreased at exponential phase in comparison with that at lag phase; compared with cells at lag phase, cells at stationary phase had higher expression of TPS1, ATH1, NTH1, and NTH2 but lower expression of TPS2. During the lag-exponential phase transition, downregulation of NTH1 and NTH2 promoted accumulation of trehalose, and to some extent, trehalose might confer ethanol tolerance to S. cerevisiae before stationary phase. During the exponential-stationary phase transition, upregulation of TPS1 contributed to accumulation of trehalose, and Tps1 protein might be indispensable in yeast cells to withstand ethanol stress at the stationary phase. Moreover, trehalose would be degraded to supply carbon source at stationary phase.

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“…Fermented soya food items and L-ergothioneine may also provide a series of beneficial antioxidant effects to minimize aging-associated damage ( Das et al, 2020 ). A perturbing consortium of gut microbiota (due to environmental factors, diet, and long-term antibiotics) may weaken the host barrier against pathogens and consequently decrease SCFA production and cause frailty, diabetes, malnutrition, and sarcopenia in the elderly ( Nakaya et al, 2014 ). Probiotics such as LP may help to modulate altered gut microbiota and associated aging hallmarks.…”

Section: Lactiplantibacillus Plantarum Effect On Aging Hallm...mentioning

confidence: 99%

Microbial dysbiosis and the aging process: a review on the potential age-deceleration role of Lactiplantibacillus plantarum

Gupta,

El-Gawaad,

Mallasiy

et al. 2024

Front. Microbiol.

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Gut microbiota dysbiosis has been a serious risk factor for several gastric and systemic diseases. Recently, gut microbiota’s role in aging was discussed. Available preclinical evidence suggests that the probiotic bacteria Lactiplantibacillus plantarums (LP) may influence the aging process via modulation of the gut microbiota. The present review summarized compelling evidence of LP’s potential effect on aging hallmarks such as oxidative stress, inflammation, DNA methylation, and mitochondrial dysfunction. LP gavage modulates gut microbiota and improves overall endurance in aging animal models. LP cell constituents exert considerable antioxidant potential which may reduce ROS levels directly. In addition, restored gut microbiota facilitate a healthy intestinal milieu and accelerate multi-channel communication via signaling factors such as SCFA and GABA. Signaling factors further activate specific transcription factor Nrf2 in order to reduce oxidative damage. Nrf2 regulates cellular defense systems involving anti-inflammatory cytokines, MMPs, and protective enzymes against MAPKs. We concluded that LP supplementation may be an effective approach to managing aging and associated health risks.

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Anti-aging and anti-microbial effects of melleolide on various types of yeast

Cited by 5 publications

References 8 publications

l-carnosine enhanced reproductive potential of the Saccharomyces cerevisiae yeast growing on medium containing glucose as a source of carbon

l-carnosine enhanced reproductive potential of the Saccharomyces cerevisiae yeast growing on medium containing glucose as a source of carbon

Changes of trehalose content and expression of relative genes during the bioethanol fermentation bySaccharomyces cerevisiae

Microbial dysbiosis and the aging process: a review on the potential age-deceleration role of Lactiplantibacillus plantarum

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