Anti-Aging Effect of Agrocybe aegerita Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota

Liu, Xiaoyan; Wu, Linxiu; Tong, Aijun; Zhen, Hongmin; Han, Dong; Yuan, Hongyang; Li, Fannian; Wang, Chengtao; Fan, Guangsen

doi:10.3390/foods11233783

Cited by 17 publications

(8 citation statements)

References 39 publications

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“…41 The Firmicutes/ Bacteroidota ratio was significantly downregulated in the Dgalactose-induced senescence model, which is one of the hallmarks of senescence affecting the gut microbiota. 42 Our study also found that LPS treatment downregulated the ratio of Firmicutes/Bacteroidota, and puerarin treatment could restore the ratio of Firmicutes/Bacteroidota. Studies have shown that Lactobacillaceae could delay aging by changing the composition of the gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

“…This also provides a theoretical basis for the possibility that puerarin may delay mammary gland aging through the “gut-mammary axis.” Studies have shown that the ratio of Firmicutes and Bacteroidota changes with life stages . The Firmicutes/Bacteroidota ratio was significantly downregulated in the D-galactose-induced senescence model, which is one of the hallmarks of senescence affecting the gut microbiota . Our study also found that LPS treatment downregulated the ratio of Firmicutes/Bacteroidota , and puerarin treatment could restore the ratio of Firmicutes/Bacteroidota .…”

Section: Discussionmentioning

confidence: 99%

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Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway

Liu,

Hu,

Zhang

et al. 2024

J. Agric. Food Chem.

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Mammary gland aging is one of the most important problems faced by humans and animals. How to delay mammary gland aging is particularly important. Puerarin is a kind of isoflavone substance extracted from Pueraria lobata, which has antiinflammatory, antioxidant, and other pharmacological effects. However, the role of puerarin in delaying lipopolysaccharide (LPS)induced mammary gland aging and its underlying mechanism remains unclear. On the one hand, we found that puerarin could significantly downregulate the expression of senescence-associated secretory phenotype (SASP) and age-related indicators (SA-β-gal, p53, p21, p16) in mammary glands of mice. In addition, puerarin mainly inhibited the p38MAPK signaling pathway to repair mitochondrial damage and delay mammary gland aging. On the other hand, puerarin could also delay the cellular senescence of mice mammary epithelial cells (mMECs) by targeting gut microbiota and promoting the secretion of gut microbiota metabolites. In conclusion, puerarin could not only directly act on the mMECs but also regulate the gut microbiota, thus, playing a role in delaying the aging of the mammary gland. Based on the above findings, we have discovered a new pathway for puerarin to delay mammary gland aging.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway

Liu,

Hu,

Zhang

et al. 2024

J. Agric. Food Chem.

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“…Evidence indicates that dietary consumption of polysaccharides can retarded the aging process and alleviate age-related diseases by modulating gut microbiota. For example, polysaccharides extracted from Agrocybe aegerita (AAPSs) reshaped the disordered intestinal flora, increased the abundance ratio of Firmicutes to Bacteroidetes, increased the abundance of beneficial bacteria Lactobacillus , and exhibited a potential antiaging effect in d -galactose-induced aging mice …”

Section: Antiaging Effects Of Polysaccharidesmentioning

confidence: 99%

Advances in Plant Polysaccharides as Antiaging Agents: Effects and Signaling Mechanisms

Deng

Wang

et al. 2023

J. Agric. Food Chem.

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Aging refers to the gradual physiological changes that occur in an organism after reaching adulthood, resulting in senescence and a decline in biological functions, ultimately leading to death. Epidemiological evidence shows that aging is a driving factor in the developing of various diseases, including cardiovascular diseases, neurodegenerative diseases, immune system disorders, cancer, and chronic low-grade inflammation. Natural plant polysaccharides have emerged as crucial food components in delaying the aging process. Therefore, it is essential to continuously investigate plant polysaccharides as potential sources of new pharmaceuticals for aging. Modern pharmacological research indicates that plant polysaccharides can exert antiaging effects by scavenging free radicals, increasing telomerase activity, regulating apoptosis, enhancing immunity, inhibiting glycosylation, improving mitochondrial dysfunction regulating gene expression, activating autophagy, and modulating gut microbiota. Moreover, the antiaging activity of plant polysaccharides is mediated by one or more signaling pathways, including IIS, mTOR, Nrf2, NF-κB, Sirtuin, p53, MAPK, and UPR signaling pathways. This review summarizes the antiaging properties of plant polysaccharides and signaling pathways participating in the polysaccharide-regulating aging process. Finally, we discuss the structure–activity relationships of antiaging polysaccharides.

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“…For instance, polysaccharides isolated from both the fruiting bodies and primordia of G. lucidum demonstrated neuroprotective properties [21,54,59,67]. In addition, based on the study conducted by Liu et al [68], it is known that polysaccharides from C. aegerita significantly prolong the lifespan of Drosophila melanogaster as a model organism and alleviate the oxidative stress induced by H 2 O 2 . Interestingly, G. applanatum, which exhibited significant AChE inhibition, also demonstrated a higher concentration of PUT and SPD compared to G. resinaceum.…”

Section: Ache Inhibitory Potentialmentioning

confidence: 99%

Polyamines in Edible and Medicinal Fungi from Serbia: A Novel Perspective on Neuroprotective Properties

Rašeta,

Kebert,

Mišković

et al. 2023

JoF

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The therapeutic effectiveness of current neurodegenerative disease treatments is still under debate because of problems with bioavailability and a range of side effects. Fungi, which are increasingly recognized as sources of natural antioxidants and acetylcholinesterase (AChE) enzyme inhibitors, may thus serve as potent neuroprotective agents. Previous studies have associated the anti-AChE and antioxidant activities of fungi mostly with polysaccharides and phenolic compounds, while other secondary metabolites such as polyamines (PAs) have been neglected. This study aimed to investigate eight edible and medicinal fungi from Serbia, marking the initial investigation into the neuroprotective capabilities of Postia caesia, Clitocybe odora, Clitopilus prunulus, and Morchella elata. Neuroprotective activity was examined using the Ellman assay, while the antioxidant capacity was tested by conducting DPPH, NO, ABTS, and FRAP tests. PA levels were determined by high-performance liquid chromatography (HPLC) coupled with fluorescent detection. Ganoderma applanatum and Lepista nuda exhibited the most robust anti-AChE (98.05 ± 0.83% and 99.94 ± 3.10%, respectively) and antioxidant activities, attributed to the synergistic effects of the total protein, total phenolic, and PA levels. Furthermore, P. caesia displayed significant AChE inhibition (88.21 ± 4.76%), primarily linked to the elevated spermidine (SPD) (62.98 ± 3.19 mg/kg d.w.) and putrescine (PUT) levels (55.87 ± 3.16 mg/kg d.w.). Our results highlight the need for thorough research to comprehend the intricate relationships between distinct fungus species and AChE inhibition. However, it is important to recognize that more research is required to identify the precise substances causing the reported inhibitory effects.

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Anti-Aging Effect of Agrocybe aegerita Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota

Cited by 17 publications

References 39 publications

Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway

Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway

Advances in Plant Polysaccharides as Antiaging Agents: Effects and Signaling Mechanisms

Polyamines in Edible and Medicinal Fungi from Serbia: A Novel Perspective on Neuroprotective Properties

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