Anti-Aging Effects of a Serum Based on Coconut Oil Combined with Deer Antler Stem Cell Extract on a Mouse Model of Skin Aging

Pham, Truc Le-Buu; Thi, Thuy Truong; Huyen, Nguyen Thi Thuong; Lao, Thuan Duc; Bình, Nguyễn Trọng; Nguyen, Quan D

doi:10.3390/cells11040597

Cited by 19 publications

(9 citation statements)

References 42 publications

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“…The skin is the largest organ in the human body, and serves as a critical protective mechanical, chemical, immune, and biological barrier against the environment. 6 The SC, the outermost layer of the epidermis, forms the main barrier and is composed of non-living corneocytes and a mixture of lipids organized in bilayers. 7 Epidermal sebum is composed of sebum secreted by the sebaceous glands and epidermal lipids produced by disintegrating SC cells.…”

Section: Discussionmentioning

confidence: 99%

N95 respirators alter facial skin physiological functions and lipidome composition in health care personnel

Li,

Wang,

Tao

et al. 2024

Skin Research and Technology

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BackgroundDuring the coronavirus disease 2019 pandemic, wearing medical respirators and masks was essential to prevent transmission.ObjectiveTo quantify the effects of N95 mask usage by measuring facial skin biophysical characteristics and changes in the lipidome.MethodsSixty healthy volunteers wore N95 respirators for 3 or 6 h. Facial images were acquired and physiological parameters were measured in specific facial areas, before and after mask‐wearing. Lipidome analysis was also performed.ResultsAfter N95 respirator usage, facial erythema was observed in both the 3 and 6 h groups. Both sebum secretion and trans‐epidermal water loss increased significantly in mask‐covered cheeks and chins after 6 h of mask wearing compared with before mask wearing (p < 0.05). Principal component analysis revealed significant differences in lipid composition after mask wearing compared with before. The ceramide subclass NS exhibited a positive correlation with stratum corneum hydration, whereas the AP subclass was negatively correlated with trans‐epidermal water loss in the 6 h group.ConclusionProlonged wear of N95 respirators may impair facial skin function and alter lipidome composition.

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Section: Discussionmentioning

confidence: 99%

N95 respirators alter facial skin physiological functions and lipidome composition in health care personnel

Li,

Wang,

Tao

et al. 2024

Skin Research and Technology

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“…The pilose antlers are a valuable traditional Chinese medicine. Studies have shown that pilose antlers have anti-inflammatory, anti-fatigue, antioxidant and anti-osteoporosis effects and can enhance immunity ( Zha et al, 2013 ; Ma et al, 2017 ; Pham et al, 2022 ; Pei et al, 2023 ). Therefore, the primary purpose of raising deer is to produce pilose antlers.…”

Section: Introductionmentioning

confidence: 99%

Hybridization alters red deer gut microbiome and metabolites

Wei,

Zeng,

et al. 2024

Front. Microbiol.

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The host genes play a crucial role in shaping the composition and structure of the gut microbiome. Red deer is listed as an endangered species by the International Union for the Conservation of Nature, and its pilose antlers have good medicinal value. Hybridization can lead to heterosis, resulting in increased pilose antler production and growth performance in hybrid deer. However, the role of the gut microbiome in hybrid deer remains largely unknown. In this study, alpha and beta diversity analysis showed that hybridization altered the composition and structure of the gut microbiome of the offspring, with the composition and structure of the hybrid offspring being more similar to those of the paternal parents. Interestingly, the LefSe differential analysis showed that there were some significantly enriched gut microbiome in the paternal parents (such as g_Prevotellaceae UCG-003, f_Bacteroidales RF16 group; Ambiguous_taxa, etc.) and the maternal parents (including g_Alistipes, g_Anaerosporobacter, etc.), which remained significantly enriched in the hybrid offspring. Additionally, the hybrid offspring exhibited a significant advantage over the parental strains, particularly in taxa that can produce short-chain fatty acids, such as g_Prevotellaceae UCG-003, g_Roseburia, g_Succinivibrio, and g_Lachnospiraceae UCG-006. Similar to bacterial transmission, metagenomic analysis showed that some signaling pathways related to pilose antler growth (“Wnt signaling pathway,” “PI3K Akt signaling pathway,” “MAPK signaling pathway”) were also enriched in hybrid red deer after hybridization. Furthermore, metabolomic analysis revealed that compared with the paternal and maternal parents, the hybrid offspring exhibited significant enrichment in metabolites related to “Steroid hormone biosynthesis,” “Tryptophan metabolism,” “Valine, leucine and isoleucine metabolism,” and “Vitamin B metabolism.” Notably, the metagenomic analysis also showed that these metabolic pathways were significantly enriched in hybrid deer. Finally, a correlation analysis between the gut microbiome and metabolites revealed a significant positive correlation between the enriched taxa in hybrid deer, including the Bacteroidales RF16 group, Prevotellaceae, and Succinivibrio, and metabolites, such as 7α-hydroxytestosterone, L-kynurenine, indole, L-isoleucine, and riboflavin. The study contributes valuable data toward understanding the role of the gut microbiome from red deer in hybridization and provides reference data for further screening potential probiotics and performing microbial-assisted breeding that promotes the growth of red deer pilose antlers and bodies, development, and immunity.

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“…An emollient is an ingredient used in skin care formulations that helps in maintaining the softness and smoothness of the skin and contributes to the moisturizing, lubricating, and conditioning effects which formed semi-occlusive films on the skin (Lodén & Maibach, 2012;Purnamawati et al, 2017;Chao et al, 2018;Pham et al, 2022). In clinical practice, it helps to reduce the itching sensation often present in dry skin while improving the appearance of the stratum corneum (Perrett & Peters, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Emollients may decrease the friction coefficient due to their lubricant properties and modify the spreading performance of the product (Savary et al, 2013). Emolliency is the softening ability that is one of the most important parameters in skin moisturization as emollient helps to balance the skin moisture (Lodén & Maibach, 2012;Pham et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Enhancing Emollient Properties of Natural and Structured Virgin Coconut Oil Creams on Skin Conditions Using Non-Invasive Skin Biophysical Methods

Ibrahim

Matmin

HAIRUL

et al. 2022

MAB

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This study aims to evaluate the emollient properties of natural-based oil creams on skin conditions. The focus is primarily on natural virgin coconut oil (VCO) and structured VCO (SVCO) which contain medium-chain triglycerides (MCTs) that have been reported to have a permeation enhancement effect on the lipophilic active ingredient. SVCO, which contains a higher amount of MCTs than VCO, was produced by lipase-catalyzed acidolysis of caprylic/octanoic acid (eight-carbon chain) and VCO. The emollient cream was prepared using the oil in water (o/w) formulation cream and it consisted of 30% (w/w) of oils, emulsifying wax, and deionized water. While in the oil phase, 5% (w/w) α-tocopherol, the model lipophilic active ingredient was added to the cream. Significant effects (p<0.05) were statistically produced in the skin moisture content, transepidermal water loss (TEWL), and skin elasticity values for all formulations as compared to the skin at T0 (before application) after the short- and long-term study periods. The skin smoothness (SEsm) and skin roughness (SEr) values, which are indicators of the skin condition, also showed significant improvement. The results indicated that VCO and SVCO creams exerted an emollient effect when applied topically and also acted as skin permeation enhancers in the formulation.

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Anti-Aging Effects of a Serum Based on Coconut Oil Combined with Deer Antler Stem Cell Extract on a Mouse Model of Skin Aging

Cited by 19 publications

References 42 publications

N95 respirators alter facial skin physiological functions and lipidome composition in health care personnel

N95 respirators alter facial skin physiological functions and lipidome composition in health care personnel

Hybridization alters red deer gut microbiome and metabolites

Enhancing Emollient Properties of Natural and Structured Virgin Coconut Oil Creams on Skin Conditions Using Non-Invasive Skin Biophysical Methods

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