Anti-Aging Effects of Black Ginseng Extract via H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress Regulation in Human Keratinocytes

Ahn, S.H.; Lee, Gye Won; Kwon, Deuk Sang; Shin, Hyun Joong; Cho, Young Ho

doi:10.3746/jkfn.2021.50.10.1019

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…ROS generated due to oxidative stress increases the expression of matrix metalloproteinase (MMP), which decomposes the ECM [ 49 ]. In particular, MMP-1 is known to significantly impact skin aging because it decomposes type I collagen and type III collagen, which account for the largest proportion of skin collagen [ 50 , 51 ]. BK3 is expected to be effective in suppressing intracellular collagen degradation, as it significantly reduced the expression of MMP-1 at a concentration of 3%.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of the Postbiotic Levilactobacillus brevis BK3 against H₂O₂-Induced Oxidative Damage in Skin Cells

Lee,

Jang

et al. 2024

J. Microbiol. Biotechnol.

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Postbiotics have various functional effects, such as antioxidant, anti-inflammatory, and anti-obesity. Levilactobacillus brevis BK3, the subject of this study, was derived from lactic acid bacteria isolated from Kimchi, a traditional Korean fermented food. The antioxidant activity of BK3 was confirmed through the measurements of 2,2-diphenyl-1-picryl-hydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and total antioxidant capacity (TAC). The wrinkle improvement effect was validated by assessing elastase inhibitory activity and collagenase inhibitory activity. The intracellular activity was confirmed using human keratinocytes (HaCaT) and human fibroblasts (HFF-1). BK3 protects skin cells from oxidative stress induced by H 2 O 2 and reduces intracellular reactive oxygen species (ROS) production. In addition, the expressions of the antioxidant genes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were upregulated. Meanwhile, matrix metalloproteinase-1 (MMP-1) and collagen type I alpha 1 (COL1A1), involved in collagen degradation and synthesis, were significantly regulated. These results suggest the possibility of utilizing BK3 as a functional ingredient with antioxidant and wrinkle-improving effects.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of the Postbiotic Levilactobacillus brevis BK3 against H₂O₂-Induced Oxidative Damage in Skin Cells

Lee,

Jang

et al. 2024

J. Microbiol. Biotechnol.

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Protective Effects of Allomyrina dichotoma Larva Extract against Oxidative Stress in H₂O₂-Treated H9c2 Cells

Shin,

Kim,

Hong

et al. 2023

JKFN

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The prevention of oxidative damage is important because it can lead to various disease conditions, such as hyperlipidemia, hypertension, and arrhythmia. Research on the protective effects of natural substances on H2O2treated H9c2 cells has been widely reported. However, little information is available on the preventive effect of Allomyrina dichotoma larva extract (ADLE) on oxidative damage. In this study, we investigated whether ADLE pretreatment has an antioxidative effect on H2O2-treated H9c2 cells. An MTT assay showed ADLE was non-cytotoxic and when co-treated decreased H2O2-induced cell death. DPPH and ABTS assays showed ADLE dose-dependently increased antioxidant activity, and FRAP assays showed ADLE increased reducing power. Furthermore, western blot revealed ADLE increased the level of proteins associated with apoptosis and antioxidant activity, and CAT and SOD assays showed their enzyme levels were higher in ADLE and H₂O₂ co-treated H9c2 cells than in H₂O₂-treated cells. The study shows that ADLE pretreatment prevents oxidative damage to H9c2 myocardial cells and has potential use as a functional material.

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Anti-Inflammatory Activities of Rumohra adiantiformis Extracts in LPS-Stimulated Macrophages

Hur,

Yoo,

Lee

2024

JKFN

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The potential of Rumohra adiantiformis, a type of Polypodiales, as a natural material was studied using a range of physiological activity studies. Rumohra adiantiformis was extracted using hot water or 70% ethanol. Total polyphenol content was higher in the ethanol extract (RUE) than in the hot water extract (RUD). In addition, the electron-donating abilities and ABTS radical scavenging activities of the two extracts were similar to those of the control group, confirming their excellent antioxidant effects. RAW 264.7 cell viability studies showed the two extracts were non-toxic and inhibited nitric oxide by >79% at 500 μg/mL. Furthermore, RUD and RUE concentration-dependently inhibited the protein and mRNA expressions of iNOS and COX-2. Therefore, the study shows that the hot water and 70% ethanol extracts of Rumohra adiantiformis have antioxidant and anti-inflammatory properties and suggests that Rumohra adiantiformis is a potentially useful functional natural material.

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Anti-Aging Effects of Black Ginseng Extract via H₂O₂-Induced Oxidative Stress Regulation in Human Keratinocytes

Cited by 3 publications

References 36 publications

Protective Effects of the Postbiotic Levilactobacillus brevis BK3 against H₂O₂-Induced Oxidative Damage in Skin Cells

Protective Effects of the Postbiotic Levilactobacillus brevis BK3 against H₂O₂-Induced Oxidative Damage in Skin Cells

Protective Effects of Allomyrina dichotoma Larva Extract against Oxidative Stress in H₂O₂-Treated H9c2 Cells

Anti-Inflammatory Activities of Rumohra adiantiformis Extracts in LPS-Stimulated Macrophages

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Anti-Aging Effects of Black Ginseng Extract via H2O2-Induced Oxidative Stress Regulation in Human Keratinocytes

Cited by 3 publications

References 36 publications

Protective Effects of the Postbiotic Levilactobacillus brevis BK3 against H2O2-Induced Oxidative Damage in Skin Cells

Protective Effects of the Postbiotic Levilactobacillus brevis BK3 against H2O2-Induced Oxidative Damage in Skin Cells

Protective Effects of Allomyrina dichotoma Larva Extract against Oxidative Stress in H2O2-Treated H9c2 Cells

Anti-Inflammatory Activities of Rumohra adiantiformis Extracts in LPS-Stimulated Macrophages

Contact Info

Product

Resources

About

Anti-Aging Effects of Black Ginseng Extract via H₂O₂-Induced Oxidative Stress Regulation in Human Keratinocytes

Protective Effects of the Postbiotic Levilactobacillus brevis BK3 against H₂O₂-Induced Oxidative Damage in Skin Cells

Protective Effects of the Postbiotic Levilactobacillus brevis BK3 against H₂O₂-Induced Oxidative Damage in Skin Cells

Protective Effects of Allomyrina dichotoma Larva Extract against Oxidative Stress in H₂O₂-Treated H9c2 Cells