Anti-aging Effects of Cedrol and Collagen-derived Peptide

Purpose: The objective of this study was to evaluate the quality of five different types of agarwood from Vietnam and 4 other areas and analyze the volatile chemical components by gas chromatography mass spectrometry (GC-MS). We attempted to identify the ingredients that have previously been reported to have skin health benefits, and reviewed their potential future use as raw materials for natural cosmetics.Methods: The five sources of Aquilaria crassna (A. crassna) were from Vietnamese, Indonesian, Malaysian, Myanmar, and Cambodian agarwoods. The volatile chemical components of each agarwood were analyzed by GC-MS. The Vietnamese agarwood was selected as a standard by identifying A. crassna through DNA analysis.Results: GC-MS analysis revealed that ‘sesquiterpene’ was contained in all the agarwood samples. The four sesquiterpene components, italicene ether, epi-γ-eudesmol, δ-guaiene, and α-agarofuran were commonly detected in all agarwood samples. Eight simple volatile aromatic compound components (1-octanol, 4-(4-methoxyphenyl)-2-butanone, 4-phenyl-2-butanone, benzaldehyde, ethylbenzene, nonanal, octanal, and 2-ethyl-1-hexanol) were commonly detected. The sesquiterpene components, α-agarofuran, β-selinene, α-curcumene, and α-santalol have been reported to have anti-inflammatory, antioxidant, antibacterial, and anti-skin cancer properties, respectively.Conclusion: This study demonstrated a substantial difference in the quality of the volatile component composition in each of the four source areas other than A. crassna from Vietnam. Agarwood contains sesquiterpene, which has a unique fragrance and is beneficial for skin health, and it is expected to be utilized as a raw material for natural cosmetics and developed in the future as a functional cosmetic with high added value.

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Antioxidant, Anti-photoaging, and Anti-wrinkle Effects of Cosmetics Containing Low-molecular-weight Peptide Complexes

Han,

Kim

2024

Asian J Beauty Cosmetol

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Purpose: This study aimed to confirm the skin improvement effects of cosmetics containing low-molecular-weight peptide complexes using in vitro and human application tests.Methods: An in vitro test was conducted to confirm the cytotoxicity, antioxidant, and anti-photoaging effects of cosmetics comprising low-molecular-weight peptide complexes. The protective effect on HacaT cells subjected to oxidative stress and collagen production in CCD-986sk cells irradiated with UV-B (Ultraviolet B) were confirmed. Moreover, to validate skin improvement effects, a human application test was performed on 20 adults aged 30–59 years. The wrinkles depth and the indentation index around the forehead, eyes, cheeks, and mouth were evaluated using ANTERA 3D CS.Results: The test material demonstrated excellent cell viability, confirming its safety on the skin. At a concentration of 0.1%, it exhibited a removal rate of reactive oxygen species (ROS) by 63.39% (p<0.001) and an increase in collagen content of 102.14% (p<0.01). Furthermore, in the human application test over 4 weeks, skin folds exhibited a decrease in average depth by 20.53% (p<0.001), and the indentation index decreased by 17.02% (p<0.001).Conclusion: Cosmetics containing low-molecular-weight peptide complexes possess excellent antioxidant, anti-photoaging, and collagen synthesis promotion properties. Their efficacy in reducing skin wrinkles and increasing skin elasticity was also confirmed. Low-molecular-weight peptide complexes could be an excellent active ingredient in cosmeceuticals.

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Anti-aging Effects of Cedrol and Collagen-derived Peptide

Cited by 3 publications

References 11 publications

Improvement of Dermal Compactness by Mixed Extracts of Three Medicinal Herbs

Improvement of Dermal Compactness by Mixed Extracts of Three Medicinal Herbs

A Comparative Analysis of the Volatile Components of Agarwood from Vietnam and other Regions

Antioxidant, Anti-photoaging, and Anti-wrinkle Effects of Cosmetics Containing Low-molecular-weight Peptide Complexes

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