Anti-aging effects of dietary phytochemicals: From
            <i>Caenorhabditis elegans</i>
            ,
            <i>Drosophila melanogaster</i>
            , rodents to clinical studies

Chen, Ju-Chi; Wang, Reuben; Wei, Chia-Cheng

doi:10.1080/10408398.2022.2160961

Cited by 7 publications

(3 citation statements)

References 161 publications

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“…A modern lifestyle characterized by high caloric intake and minimal physical activity in humans results in high lipid storage levels that reduce overall lifespan [68]. Nevertheless, several studies have shown that several phytochemicals can expand the lifespan using Drosophila as a model (Figure 2) [69].…”

Section: Development and Lifespanmentioning

confidence: 99%

Drosophila melanogaster as a Translational Model System to Explore the Impact of Phytochemicals on Human Health

Lopez-Ortiz,

Gracia-Rodriguez,

Belcher

et al. 2023

IJMS

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Fruits, vegetables, and spices are natural sources of bioactive phytochemicals, such as polyphenols, carotenoids, flavonoids, curcuminoids, terpenoids, and capsaicinoids, possessing multiple health benefits and relatively low toxicity. These compounds found in the diet play a central role in organism development and fitness. Given the complexity of the whole-body response to dietary changes, invertebrate model organisms can be valuable tools to examine the interplay between genes, signaling pathways, and metabolism. Drosophila melanogaster, an invertebrate model with its extensively studied genome, has more than 70% gene homology to humans and has been used as a model system in biological studies for a long time. The notable advantages of Drosophila as a model system, such as their low maintenance cost, high reproductive rate, short generation time and lifespan, and the high similarity of metabolic pathways between Drosophila and mammals, have encouraged the use of Drosophila in the context of screening and evaluating the impact of phytochemicals present in the diet. Here, we review the benefits of Drosophila as a model system for use in the study of phytochemical ingestion and describe the previously reported effects of phytochemical consumption in Drosophila.

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Section: Development and Lifespanmentioning

confidence: 99%

Drosophila melanogaster as a Translational Model System to Explore the Impact of Phytochemicals on Human Health

Lopez-Ortiz,

Gracia-Rodriguez,

Belcher

et al. 2023

IJMS

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“…Using C. elegans as a model, several potential gerontogens have been identified, including the mycotoxin zearalenone and the plasticizer phthalate . Furthermore, C. elegans also represents a suitable model for the screening of phytochemicals with potential beneficial antiaging effects. , This study investigated the toxic effects of BaP on the aging process of C. elegans using aging markers that include lifespan, aberrant protein aggregation, decline in motility and pharyngeal pumping, ROS accumulation, tolerance to heat stress, and expression of heat shock proteins. Furthermore, we explored whether dietary supplementation with TAN could alleviate the toxic effects of BaP on the aging process in the C. elegans model.…”

Section: Introductionmentioning

confidence: 99%

Tangeretin Supplementation Mitigates the Aging Toxicity Induced by Dietary Benzo[a]pyrene Exposure with Aberrant Proteostasis and Heat Shock Responses in Caenorhabditis elegans

How,

Cheng,

et al. 2023

J. Agric. Food Chem.

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“…There are several reviews on the antiaging properties of medicinal foods and plants but these are not comprehensive. Although many of the studies were conducted on antiaging potentials of specific parts of the plants (Chen et al., 2020; Rusu et al., 2019), some focused on specific plant products (Bhullar & Wu, 2020; Chen et al., 2023; Dhanjal et al., 2020; Meccariello & D'Angelo, 2021), whereas others presented studies only in specific models (Okoro et al., 2021). As such, there is no comprehensive study in the literature that presents an overview of plants and foods that can be used to manage aging to date.…”

Section: Introductionmentioning

confidence: 99%

Medicinal foods and plants with antiaging properties: A review of in vitro and in vivo studies

Kazeem,

Mellem,

Sabiu

2023

Food Frontiers

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Aging is a natural process by which organisms experience physiological decline leading to susceptibility to morbidity and mortality. There are no known antiaging drugs but there is a myriad of medicinal foods and plants that have been used in managing the state. Several studies have also been conducted on the antiaging properties of medicinal plants and foods, but these pieces of information are scattered. This paper attempts to integrate available information on medicinal foods and plants as well as isolated chemical compounds with antiaging potential. It also provides different models (in vitro and in vivo) that are used in evaluating the potency of natural products. Current literature on the subject was obtained from different databases such as PubMed, Google Scholar, and Web of Science. A total of 119 medicinal plants and 50 isolated compounds were reported in this study. Different models were also used to evaluate the efficacy of these plants which include in vitro (enzyme inhibition, use of cell lines) and in vivo (Caenorhabditis elegans, yeast, fruit fly, mice, and rats) models. It can be concluded that medicinal foods and plants are reservoirs of potential therapeutic agents that can efficiently modulate metabolic processes implicated in aging and its associated disorders.

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Anti-aging effects of dietary phytochemicals: From Caenorhabditis elegans , Drosophila melanogaster , rodents to clinical studies

Cited by 7 publications

References 161 publications

Drosophila melanogaster as a Translational Model System to Explore the Impact of Phytochemicals on Human Health

Drosophila melanogaster as a Translational Model System to Explore the Impact of Phytochemicals on Human Health

Tangeretin Supplementation Mitigates the Aging Toxicity Induced by Dietary Benzo[a]pyrene Exposure with Aberrant Proteostasis and Heat Shock Responses in Caenorhabditis elegans

Medicinal foods and plants with antiaging properties: A review of in vitro and in vivo studies

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