Anti-aging formula protects skin from oxidative stress-induced senescence through the inhibition of CXCR2 expression

Zhu, Shan; Jia, Linlin; Wang, Xiang; Liu, Tao; Qin, Wenxiao; Ma, Hongfei; Lv, Yingshuang; Hu, Jing; Guo, Qianyu; Tan, Siyi; Yue, Xiaofeng; Yan, Yiqi; Liu, Tao; Liu, Yan; Xia, Qingmei; Zhang, Peng; Zhang, Han; Li, Nan

doi:10.1016/j.jep.2023.116996

Cited by 6 publications

(3 citation statements)

References 58 publications

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“…Inflammatory senescence is a chronic [64], low-grade, age-related inflammatory state that is caused by various factors such as oxidative stress [2,65], DNA damage [66], and cell metabolism disorder [67]. It is directly related to immune cell senescence in addition to non-immune-cell-source senescent tissue cells in the body.…”

Section: Effects Of Inflammation Caused By Hyperimmune Function On Sk...mentioning

confidence: 99%

Research Progress in Skin Aging and Immunity

He,

Gao,

Xie

2024

IJMS

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Skin aging is a complex process involving structural and functional changes and is characterized by a decrease in collagen content, reduced skin thickness, dryness, and the formation of wrinkles. This process is underpinned by multiple mechanisms including the free radical theory, inflammation theory, photoaging theory, and metabolic theory. The skin immune system, an indispensable part of the body’s defense mechanism, comprises macrophages, lymphocytes, dendritic cells, and mast cells. These cells play a pivotal role in maintaining skin homeostasis and responding to injury or infection. As age advances, along with various internal and external environmental stimuli, skin immune cells may undergo senescence or accelerated aging, characterized by reduced cell division capability, increased mortality, changes in gene expression patterns and signaling pathways, and altered immune cell functions. These changes collectively impact the overall function of the immune system. This review summarizes the relationship between skin aging and immunity and explores the characteristics of skin aging, the composition and function of the skin immune system, the aging of immune cells, and the effects of these cells on immune function and skin aging. Immune dysfunction plays a significant role in skin aging, suggesting that immunoregulation may become one of the important strategies for the prevention and treatment of skin aging.

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Section: Effects Of Inflammation Caused By Hyperimmune Function On Sk...mentioning

confidence: 99%

Research Progress in Skin Aging and Immunity

He,

Gao,

Xie

2024

IJMS

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“…The investigation of synthetic compounds, such as ferulic acid [178] and quercetin [179], and natural compounds, such as nectrandrin B [180], used as senotherapy, demonstrates action that aims to maintain and progress the cell cycle, reversing senescence through a reduction in ROS and inhibition of the p16, p21, p27, p53 pathways. Nectrandrin B [180] is a natural compound composed of six herbs (Rehmannia glutinosa, Panax Ginseng, Asparagus cochinchinensis, Ophiopogon japonicus, Cortex Lycii., Poria cocos) [181] and Yang Yan Qing E Wan (YYQEW) [182].…”

Section: Strategies To Prevent Skin Senescencementioning

confidence: 99%

Cutaneous Redox Senescence

Sarandy,

Gonçalves,

Valacchi

2024

Biomedicines

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Our current understanding of skin cell senescence involves the role of environmental stressors (UV, O3, cigarette smoke, particulate matter, etc.), lifestyle (diet, exercise, etc.) as well as genetic factors (metabolic changes, hormonal, etc.). The common mechanism of action of these stressors is the disturbance of cellular redox balance characterized by increased free radicals and reactive oxygen species (ROS), and when these overload the intrinsic antioxidant defense system, it can lead to an oxidative stress cellular condition. The main redox mechanisms that activate cellular senescence in the skin involve (1) the oxidative damage of telomeres causing their shortening; (2) the oxidation of proteomes and DNA damage; (3) an a in lysosomal mass through the increased activity of resident enzymes such as senescence-associated β-galactosidase (SA-β-gal) as well as other proteins that are products of lysosomal activity; (4) and the increased expression of SASP, in particular pro-inflammatory cytokines transcriptionally regulated by NF-κB. However, the main targets of ROS on the skin are the proteome (oxi-proteome), followed by telomeres, nucleic acids (DNAs), lipids, proteins, and cytoplasmic organelles. As a result, cell cycle arrest pathways, lipid peroxidation, increased lysosomal content and dysfunctional mitochondria, and SASP synthesis occur. Furthermore, oxidative stress in skin cells increases the activity of p16INK4A and p53 as inhibitors of Rb and CDks, which are important for maintaining the cell cycle. p53 also promotes the inactivation of mTOR-mediated autophagic and apoptotic pathways, leading to senescence. However, these markers alone cannot establish the state of cellular senescence, and multiple analyses are encouraged for confirmation. An updated and more comprehensive approach to investigating skin senescence should include further assays of ox-inflammatory molecular pathways that can consolidate the understanding of cutaneous redox senescence.

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“…6 Meanwhile, Shenqi can alleviate the damage of tight junctions in senescent sertoli cells via a mechanism potentially related to the down-regulation of the p38MAPK signaling pathway. 7 Notably, recent studies have shown that TCM can stimulate the oxidative stress response and attenuate the aging process, 8 , 9 suggesting that TCM may be strongly associated with anti-aging and making the impact of TCM on aging and ARDs a promising and far-reaching topic. In this review, we discuss the close relationship between herbal medicine and ARDs by the effects of herbal medicine in anti-aging and ARDs, and the mechanisms underlying the role of herb medicine in IRDs.…”

Section: Introductionmentioning

confidence: 99%

Potential Effects of Traditional Chinese Medicine in Anti-Aging and Aging-Related Diseases: Current Evidence and Perspectives

Ding,

Ma,

Meng

et al. 2024

CIA

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Aging and aging-related diseases present a global public health problem. Therefore, the development of efficient anti-aging drugs has become an important area of research. Traditional Chinese medicine is an important complementary and alternative branch of aging-related diseases therapy. Recently, a growing number of studies have revealed that traditional Chinese medicine has a certain delaying effect on the progression of aging and aging-related diseases. Here, we review the progress in research into using traditional Chinese medicine for aging and aging-related diseases (including neurodegenerative diseases, cardiovascular diseases, diabetes, and cancer). Furthermore, we summarize the potential mechanisms of action of traditional Chinese medicine and provide references for further studies on aging and aging-related diseases.

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Anti-aging formula protects skin from oxidative stress-induced senescence through the inhibition of CXCR2 expression

Cited by 6 publications

References 58 publications

Research Progress in Skin Aging and Immunity

Research Progress in Skin Aging and Immunity

Cutaneous Redox Senescence

Potential Effects of Traditional Chinese Medicine in Anti-Aging and Aging-Related Diseases: Current Evidence and Perspectives

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